Protein Alignment Oatp74D and Slco4c1

DIOPT Version :10

• Sequence 1: NP_648989.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_001002024.2
• Gene: Slco4c1 / 432363
• RGDID: 1303048
• Length: 724
• Species: Rattus norvegicus
• Alignment Length: 748
• Identity: 212/748 - (28%)
• Similarity: 323/748 - (43%)
• Gaps: 138/748 - (18%)

  Fly    52 QHNNGTTNGEVTTPPPSTVLYESTPSNNNEWKAPEDLGHLKNGLGNILSSNNNGTGNGHSLSEKY 116
            |.:.|..|.......|.|....|...:..|..|             :.|.|.|| |:....||..
  Rat     2 QGSKGVENPAFVPSSPDTPRRASASPSQVEVSA-------------VASRNQNG-GSQPRESEDP 52

  Fly   117 AHEQAPLTGGYKLPPRSSESEESDFDSDLNGGSSAESSSSCGLFGCRPRWARRFASTHVFMVVFL 181
            .....|......| |.|.|...|.. |:|..|       .||.....|:..:|..:...|::.:.
  Rat    53 QKSTEPSPPSSTL-PASDEPPGSQL-SELEEG-------PCGWRNFHPQCLQRCNNPKGFLLHYC 108

  Fly   182 LAYILQGMYMTYFVSV-ITTIEKLFQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHRPRWIAC 245
            |..:.||:.:...|:: |:||||.:::||..||::.|:.::.....::.:::|..|||:|||:|.
  Rat   109 LLALTQGIVVNGLVNISISTIEKRYEMKSSLTGLISSSYDISFCVLSLFVSFFGERGHKPRWLAF 173

  Fly   246 GMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQVSPPNNSFSSHWLNASSEQVNPNLCILGGNQ 310
            ...:..:.|...:||||..|...:  ..|.:.|                         |:
  Rat   174 ASFMIGLGALVFSLPHFFSGRYEL--GTIFEDT-------------------------CL----- 206

  Fly   311 THSGSECNEERQLEQASHSKITVIVLCIFFGSLLSSGIGQTAVATLGIPYIDDNVGSKQSPMYMA 375
            |.:.:.|        ||.:.:......:|....|..|.|.|.:.|||..:|||:|.:.:|.:|:.
  Rat   207 TRNSTRC--------ASSTSLLSNYFYVFVLGQLLLGTGGTPLYTLGTAFIDDSVPTHKSSLYIG 263

  Fly   376 VTIGMRILGPASGFIFGSFCTRWYVNFS-NPGFDAT--DPRWIGAWWLGPVAIGSLMLLASIAMF 437
            :...|.|||||.|::.|......|::.: ....|.|  ||||:||||:| ..:..|...:.|..|
  Rat   264 IGYSMSILGPAIGYVLGGQLLTMYIDVAMGQSSDLTEDDPRWLGAWWIG-FLLAWLFAWSLIMPF 327

  Fly   438 S-FPKQLRGKQK-PPGQT-------ATPAAPVEPEEKPKLKDFPKTVRRQLSNDILMFRTASCVF 493
            | |||.|.|..| ..|:|       :|....::......:||||..|:..:.|.:.:....|...
  Rat   328 SCFPKHLPGTAKIQAGKTSQTHQNNSTSFQHMDENFGKSIKDFPTAVKNLMRNTVFICLVLSTTS 392

  Fly   494 HLLPIAGLYTFLPKYLETQFRLATYDANMIAAFCG--ILVMG--IGIVISGLFILKRKPTAR--- 551
            ..|...|..|||||::|.||.|    .:..||..|  :|:.|  :|.::.|:.:.|.|...:
  Rat   393 EALVTTGFATFLPKFIENQFGL----TSSFAATLGGAVLIPGAALGQILGGVLVSKFKMKCKNTM 453

  Fly   552 -------GVAAWIAFTALVYSAGMIILMFIGCSMNDFAGYKPS---DGNSPALIEPTCSAALNCT 606
                   |||..::|          :.::..|....|||...|   .|....|..| |:|  ||.
  Rat   454 KFALCTSGVALMLSF----------VFIYAKCENGPFAGVSESYNGTGEMGNLTAP-CNA--NCN 505

  Fly   607 CDKENFAPIC-ADGKMYISACHAGC--SSSSLRPSDNRTLYSDCACI------------PDAPEA 656
            |.:..:.|:| :||..|.|.|.|||  |.|:.:|.    .|.:|:||            ||. ||
  Rat   506 CLRSYYYPLCGSDGVQYFSPCFAGCLNSVSNRKPK----AYYNCSCIERKVDITSTAESPDF-EA 565

  Fly   657 VNGYCDNNCKNFIYFILIFAICV---FMHSTSEVGSMLLVMRCTHPKDKAMAMGVIQSAIGLFGN 718
            ..|.|...|.|...|:.||.|.|   ||..|....|   ::||.:.:.:::|:||....:.|.|.
  Rat   566 RAGKCKTQCSNLPIFLGIFFITVIFTFMAGTPITVS---ILRCVNHRQRSLALGVQFMLLRLLGT 627

  Fly   719 VPCPIIYGAVVDSACLIWK-SVCGKHGACSLYD 750
            :|.|||:|..:||.|::|. :.||..|||.:||
  Rat   628 IPGPIIFGVTIDSTCVLWDINECGTKGACWIYD 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_648989.1	OATP	175..754	CDD:460821	184/625 (29%)
Slco4c1	NP_001002024.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..80		22/93 (24%)
		MFS_SLCO4C_OATP4C	100..604	CDD:341021	161/569 (28%)