DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp74D and Oatp58Db

DIOPT Version :9

Sequence 1:	NP_001163460.1	Gene:	Oatp74D / 39954	FlyBaseID:	FBgn0036732	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_611658.3	Gene:	Oatp58Db / 37544	FlyBaseID:	FBgn0034715	Length:	680	Species:	Drosophila melanogaster

Alignment Length:	713	Identity:	209/713 - (29%)
Similarity:	349/713 - (48%)	Gaps:	74/713 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 SSESEESDFDSDLNGGSSA--------ESSSSCGLFGCRPRWARRFASTHVFMVVFLLAYILQGM 189
            |.|.|.|.|..|...|.:.        .|.::||....|....:|||:.|:|::|:.:|.....|
  Fly     3 SEEIEASKFLKDKEAGINVADDEKRLNSSDTTCGFSIFRGPALQRFATAHMFVIVYGIASCFLAM 67

  Fly   190 YMTYFVSVITTIEKLFQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAA 254
            ..|||...|||:||.|.|.:|.:|::...:::..:.::..|:|:|.|||||||:|.|:::.:|..
  Fly    68 AFTYFTGTITTMEKRFNIPTKISGLITVGNDISTVFSSAFLSYYASRGHRPRWVALGLIIIAIFC 132

  Fly   255 FSCALPHFIFGEQLMHSSVILQQTQVSPPNNSFSSHWLNASSEQVNPNLCILGGNQTHSGSECNE 319
            .....||..:|.    ....|:.|:....:.||.:. ||.:.:  |.:||      ....|.|
  Fly   133 LLMLTPHIFYGP----GEEALRLTEEYGMSESFGAS-LNITEK--NDSLC------HEKNSNC-- 182

  Fly   320 ERQLEQASHSKITVIVLCIFFGSLLSSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILG 384
               ||:|  ...|.|||  ||.:....|||.:.....|:.|:|||..|.::|..::.:..:|:||
  Fly   183 ---LERA--GDYTPIVL--FFIAQFIGGIGCSLFYAPGLSYMDDNSASSKTPAMLSWSSFLRMLG 240

  Fly   385 PASGFIFGSFCTRWYVN-FSNPGFDATDPRWIGAWWLGPVAIGSLMLLASIAMFSFPKQL-RGKQ 447
            ||.||...|.|.|.|:: |..|.....||||:||||:|.:.:..::.::::.:..|||:: |.|.
  Fly   241 PAMGFSMVSLCLRLYIDPFKKPLITTNDPRWMGAWWIGWILLTFILTISAVFVGMFPKEMPRAKA 305

  Fly   448 ---KPPGQTATPAAPVEPEEKPKLKDFPKTVRRQLSNDILMFRTASCVFHLLPIAGLYTFLPKYL 509
               |..|:...|.|      ....:|...:::|..||.:.::...:.:.:|......:.|.|||:
  Fly   306 RRLKADGEEDIPLA------GRSFQDMLDSLKRLASNKVYVYNMLASILYLFGYMPYWIFTPKYI 364

  Fly   510 ETQFRLATYDANMIAAFCGILVMGIGIVISGLFILKRKPTARGVAAWIAFTALVYSAGMIILMFI 574
            |.|:|.:...:.|......:.....||:|||..|.|.||:||.:|||......:..|||:..:.:
  Fly   365 EIQYRQSASTSTMATGTWALGFSAAGILISGYVISKYKPSARAMAAWNFVVDYLTVAGMLCYVLV 429

  Fly   575 GCSMNDFAGYKPSDGNSPALIEPT---CSAALNCTCDKENFAPICA-DGKMYISACHAGCSSSSL 635
            ||..:|.|       ||.::: ||   |||  :|.|:...:||:|: :...:||||||||:..::
  Fly   430 GCDESDRA-------NSLSIV-PTGDSCSA--SCVCEYVYYAPVCSPENITFISACHAGCTDKAI 484

  Fly   636 RPSDNRTLYSDCACIPDAPE----------------AVNGYCDNNC-KNFIYFILIFAICVFMHS 683
            ... .:|:|:.|.|:.:...                |::|.|..:| |.|:.|:.:.....|:.:
  Fly   485 NEL-GKTIYTGCRCMGNVSSIISLSNVTSLASQSQIAMDGACPVDCNKQFLIFLAVMCFLKFVGA 548

  Fly   684 TSEVGSMLLVMRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIWKSVCGKHGACSL 748
            |....::||.:||...|||..::|.......:...:|.||::|.::||.||:|...|...|.|.:
  Fly   549 TGRSSNLLLALRCVPSKDKTFSLGFGSMVYSVLAFIPSPIVFGWMLDSYCLVWGKTCSSKGNCWI 613

  Fly   749 YDADTFRQYFLGITAGIMFLAFLMDLVVWRKAHRIDIAPEDPQEGGPASNGRTLEVSESKQPI 811
            ||..:.|.....:.|.::||....::.||..|..:.:..|| ::...|.....:|:.|....:
  Fly   614 YDTKSLRYTMNLVCASLIFLGSFWNIGVWYHAKDMKVFDED-EKTVQAKQSDDIELKEKPNDV 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_001163460.1	OATP	175..754	CDD:335235	182/604 (30%)
Oatp58Db	NP_611658.3	OATP	53..619	CDD:281175	182/604 (30%)
		MFS	55..>410	CDD:119392	116/382 (30%)
		KAZAL_SLC21	447..499	CDD:238650	20/54 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446200
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4773
orthoMCL	1	0.900	-	-		OOG6_108756
Panther	1	1.100	-	-	P	PTHR11388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3798
	7	6.850