Protein Alignment Oatp74D and Slco6d1

DIOPT Version :10

• Sequence 1: NP_648989.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: XP_017452073.1
• Gene: Slco6d1 / 367321
• RGDID: 1359388
• Length: 723
• Species: Rattus norvegicus
• Alignment Length: 780
• Identity: 175/780 - (22%)
• Similarity: 293/780 - (37%)
• Gaps: 184/780 - (23%)

  Fly   119 EQAPLTGG---------------YKLPPRSSES-----EE----SDFDSDLNGGSSAESSSSCGL 159
            ||.|:..|               .|..||:.:.     ||    |.|...|..||
  Rat    13 EQVPVVEGDEHRETAHPRKIETYMKTVPRAMKKFADIPEEKMPHSQFSDSLEEGS---------- 67

  Fly   160 FGCRP---RWARRFASTHVFMVVFLLAYILQGMY-------MTYFVSVITTIEKLFQIKSKTTGI 214
            ||..|   ...:||.:.:.|:..:.|..:..||.       :..:||.::.    .::::.|.|
  Rat    68 FGLGPLVFPCLQRFNNINCFLTAYFLGTMAHGMIFGLVDQSLKVYVSELSP----SKLETLTMG- 127

  Fly   215 LLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQ 279
              |..::.....:::..:|.|||:|.||:.....:..:|:...|:|.|.:       .:|...|
  Rat   128 --SGDDLAAFLVSLVGAHFGGRGNRVRWMVAACFVTGLASMVFAIPFFNY-------EIIKLGT- 182

  Fly   280 VSPPNNSFSSHWLNASSEQVNPNLCILGGNQTHSGSECNEERQLEQASHSKITVI---VLCIF-- 339
                               |...|||.|...|   ..|  ||          |||   ..||.
  Rat   183 -------------------VTDELCIEGKKTT---KVC--ER----------TVIPHKSTCIAFF 213

  Fly   340 -FGSLLSSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRWYVNFS 403
             ||..| .||.......|...:|.|:|.:..|.:|:|:......:|...|::.|         ..
  Rat   214 NFGQFL-HGIAGMPFYLLAFSFIFDHVPTCSSGLYLAIADTALSVGYVLGYLVG---------IR 268

  Fly   404 NPGFDA-TDPRWIG----------AWWLGPVAIGSLMLLASIAMFSFPKQLRGKQ--------KP 449
            |..|.. .|.:.:|          .||....|:.......::.:..||.:|||.|        :|
  Rat   269 NRMFPVKEDMKAVGHVQQFRILQRNWWRSYFAVAVFAFCTTLPLSCFPSRLRGAQQIRLEKSKEP 333

  Fly   450 PGQTATPAAPVEPEEKPKLKDFPKTVRRQLSNDILMFRTASCVFHLLPIAGLYTFLPKYLETQFR 514
            |   .......:.|.:|.||.....:...|.|.:::.:|...|...|.:.....||||:|::.|.
  Rat   334 P---TIDRRLKDKEIQPGLKGVLHAIWCLLRNPLVLTQTFCQVTKSLTLKSSGYFLPKFLQSHFL 395

  Fly   515 LATYDANMIAAFCGILVMG---IGIVISGLFILKRKPTARGVAAWIAFTALVYSAGMIILMFIGC 576
            :...:|:::.   |:.|:.   ||..:.|..:.:.:.:.:.|..::..::.:.....::..|..|
  Rat   396 IVPTNASILT---GMFVLPGALIGRFLGGYIVDRLQMSTKVVLKFMMVSSFISVVLFLLTFFWSC 457

  Fly   577 SMNDFAGYKPSDGNSPALIEPTCSAALNCTCDKENFAPICA-DGKMYISACHAGCSSSSLRPSDN 640
            ....|||..........|...|......|.|...:::.||. |.|.|.|||.|||.:|  :|...
  Rat   458 ETAGFAGINDDYDGLGKLGNFTAPCNEYCGCTMTDYSTICGRDEKQYFSACFAGCRAS--KPLRK 520

  Fly   641 RTLYSDCACIPD---AP-------EAVNGYCDNNCKNF-IYFILIFAICVFMHSTSEVGSMLLVM 694
            ...|.:|:||.:   ||       :||:|.|:..|... :.|...||..||.:..| |.|.::|:
  Rat   521 EKAYYNCSCIKEGLTAPDDDGQFFDAVSGTCNTKCLTLPLLFAFYFAATVFSNFCS-VPSFMIVL 584

  Fly   695 RCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIWK-SVCGKHGACSLYDAD----TF 754
            :.......:|::||..:.....|:||..:::.:..|..|..|. :.||:.|.|.:|:..    ||
  Rat   585 KSVPASWNSMSLGVTYTIWRFLGSVPDHLLFESTSDYTCNFWDINSCGEKGRCWIYNKKNLLFTF 649

  Fly   755 RQ-------------------------YFLGITAGIMFL--AFLMDLVVWRKAHRIDIAPEDPQE 792
            :.                         ..:.|:.|::.|  .:..|.||..|...:.|..:|.:|
  Rat   650 QSTSDKHIEDIKLNKGICDISARSQQGISMQISTGLLCLYGIYRHDYVVKEKNKSLPIHVKDEKE 714

  Fly   793  792
              Rat   715  714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_648989.1	OATP	175..754	CDD:460821	144/630 (23%)
Slco6d1	XP_017452073.1	MFS	84..585	CDD:475125	130/568 (23%)