DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp74D and Oatp30B

DIOPT Version :9

Sequence 1:	NP_001163460.1	Gene:	Oatp74D / 39954	FlyBaseID:	FBgn0036732	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster

Alignment Length:	911	Identity:	254/911 - (27%)
Similarity:	401/911 - (44%)	Gaps:	180/911 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DVEAAAQVQSLGGKPSNGHGQLNGNGYHQNGGRRDSSQAFTPLLSQHNNGTTNGEVTTPPPSTVL 71
            ||.|.....|..|..:|..|..|..|:.    |::|....|.|.|:.|:|..:.     ..:.:.
  Fly    30 DVGAGNASSSSNGHIANDAGTANRKGHR----RQESMYQMTGLYSETNSGDDSS-----IDAALD 85

  Fly    72 YESTPSNNNEWKAPEDLGHLKNGL-GNILSSN-NNGTGNG------HSLSEKYAHEQAPLTGGYK 128
            ::|.|             |..:.| |:.|.|. .:|.|.|      .|::.| .|.:....|...
  Fly    86 HDSQP-------------HATSYLAGDQLPSTVGSGPGGGGPSAVADSVTVK-CHSRQASAGKCP 136

  Fly   129 LPPRSSESEESDFDSDLNGGSSAESSSSCGLFGCRPRWARRFASTHVFMVVF-LLAYILQGMYMT 192
            ..|      |.|||.:      ...|..||:..|||...:|||...:|:|:. ||..:.|.:...
  Fly   137 ADP------EEDFDEE------QFRSGDCGILNCRPYGIQRFARIKIFVVLLSLLVMMQQALSSG 189

  Fly   193 YFVSVITTIEKLFQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSC 257
            |..||||||||.|:|.|..:|::.|:.|:|.:.|.:.::|...|.|.|.||..|.|:..|.:...
  Fly   190 YINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMGIGSLVF 254

  Fly   258 ALPHFIFGEQLMHSSVILQQTQVSPPNNSFSSHWLNASSEQVNPNLCI------LG------GNQ 310
            .:|||. ||                ||...:.  :|.:|:.:..:..:      ||      .||
  Fly   255 MVPHFT-GE----------------PNPGIAI--VNKTSDNICKSALVRDQDMDLGRLSSGLSNQ 300

  Fly   311 THSGSECNEERQLEQASHSKITVIVLCIFFGSLLSSGIGQTAVATLGIPYIDDNVGSKQSPMYMA 375
            ..:.....|:..||  ..:..|..||......|| .|.|.:.:.|||..|:||:|.::.|.||:.
  Fly   301 PLAPHTLREDNCLE--GKASTTGPVLLFVLAQLL-LGCGGSPLFTLGTTYVDDHVRTESSSMYIG 362

  Fly   376 VTIGMRILGPASGFIFGSFCTRWYV-NFSNPGFDAT--DPRWIGAWWLGPVAIGSLMLLASIAMF 437
            ....|...||..||:.|::...::: :.|:.....|  |.||:|.||.|.:..|.::|:.::..|
  Fly   363 FMYSMGAFGPVVGFLLGAYLLSFHMDSLSSTTISITPGDRRWVGMWWGGFLLCGVILLVVAVPFF 427

  Fly   438 SFPKQL-RGKQK-----------PPGQTATPA-------------APVEPEEK----PK------ 467
            ||||.| |.|:|           |....||.|             |....|::    ||
  Fly   428 SFPKVLAREKKKIRKSSVVQPVLPNNSRATVATDEMGKVKKLEIVAVTSKEDQSQAPPKVDTGYG 492

  Fly   468 --LKDFPKTVRRQLSNDILMFRTASCVFHLLPIAGLYTFLPKYLETQFRLATYDANMIAAFCG-I 529
              :||.|:::.|.:.|.:.:.........|:.::|...||||||||||.|....||:   |.| |
  Fly   493 KDIKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANI---FTGSI 554

  Fly   530 LVMG--IGIVISGLFILKR---KPTARGVAAWIAFTALVYSAGMIILMFIGCSMNDFAG----YK 585
            .|.|  |||.:.|. ||||   ||  :|...::..|.::..|...:|.|:||.....||    |.
  Fly   555 AVPGACIGIFLGGC-ILKRFQLKP--KGAVQFVLITNVICLACYAMLFFLGCDNLKMAGTTIPYY 616

  Fly   586 PSDGNSPALIEP-----TCSAALNCTCDKENFAPICA-DGKMYISACHAGCSSSSLRPSDNRTLY 644
            .|:.:...|.:|     |.:....|.|......|:|. :|..|.|.|||||::.|   |.:.|.|
  Fly   617 TSNKHGSTLEQPFQVNLTAACNFGCECLTSEVEPVCGNNGLTYFSPCHAGCTAFS---STSNTNY 678

  Fly   645 SDCAC-----------------------------IPDAPEAVNGYCDNNCKNFIYFILIFAICVF 680
            ::|||                             :...|.|..|.|...|:....|:::.....|
  Fly   679 TNCACVRANISSSIYRGAGGSQAQALSANENFAEVTVVPVATAGPCATPCRTIYPFLILLFFMTF 743

  Fly   681 MHSTSEVGSMLLVMRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIWKSVCG-KHG 744
            :.:::::..:::|:|....::::.|:|:......|||.:|.||::|.::||.|::|||.|| |.|
  Fly   744 LVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIPAPILFGNLIDSTCILWKSSCGEKGG 808

  Fly   745 ACSLYDADTFRQYFLGITAGIMFLAFLMDLVVW---RKAHRID----IAPEDPQEGGPASNGRTL 802
            .|.:||.:.||..::|:.|.:..:|.::.:|.|   |:..:::    :...||..|...|..:..
  Fly   809 RCLIYDIEKFRYKYVGLCASVKLIALVIFMVDWWLVRRRKQLEKMKPLNASDPIIGSIISLDKLF 873

  Fly   803 E 803
            |
  Fly   874 E 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_001163460.1	OATP	175..754	CDD:335235	197/677 (29%)
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	197/677 (29%)
		MFS	174..>433	CDD:119392	85/280 (30%)
		MFS	512..>600	CDD:304372	34/93 (37%)
		KAZAL_SLC21	633..684	CDD:238650	19/53 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446214
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840