DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp74D and slco1d1

DIOPT Version :9

Sequence 1:	NP_001163460.1	Gene:	Oatp74D / 39954	FlyBaseID:	FBgn0036732	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001335015.1	Gene:	slco1d1 / 326845	ZFINID:	ZDB-GENE-030131-5044	Length:	689	Species:	Danio rerio

Alignment Length:	711	Identity:	197/711 - (27%)
Similarity:	325/711 - (45%)	Gaps:	103/711 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 VFMVVFLLAYILQGMYMTYFVSVITTIEKLFQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHR 239
            :|:......:..:....:|..|.:|.||:.|.:.|...|.:..:.|:|.:.....::||..:.||
Zfish    16 MFLAAMCFVFFAKAFQGSYMKSSVTQIERRFDVPSSLIGFIDGSFEIGNLFVIAFVSYFGAKLHR 80

  Fly   240 PRWIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQVSPPNNSFSSHWLNAS---SEQVNP 301
            ||.||.|.::.|..:|..|:|||..|:....|::               ||: :||   :|.|.|
Zfish    81 PRLIAAGCLVMSAGSFITAMPHFFQGQYKYESTI---------------SHF-SASVNGTENVLP 129

  Fly   302 NLCILGGN--------QTHSGSECNEERQLEQASHSKITVIVLCIFFGSLLSSGIGQTAVATLGI 358
              |:...:        ...|.:||      |:||.|.:.   |.:|.|::| .|||:|.|..||:
Zfish   130 --CLTNASLAQDSEIPTVESQAEC------EKASSSSLW---LFVFLGNML-RGIGETPVMPLGL 182

  Fly   359 PYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRWYVNFSNPGFDA-----TDPRWIGAW 418
            .|:||....:.:..|:|:...:.|:||..||:.||||.:.||:......|:     .|.||:|||
Zfish   183 SYLDDFSREENTAFYLALIQTVGIMGPMFGFMLGSFCAKLYVDIGTVDLDSITINYKDSRWVGAW 247

  Fly   419 WLGPVAIGSLMLLASIAMFSFPKQLRGKQKPPGQTATPAAPV---------------EPEEKPK- 467
            |||.:..|.:||||.|..:..||.|. :|..|.....|.||.               .|..||.
Zfish   248 WLGFLVTGGVMLLAGIPFWFLPKSLT-RQGEPESEKKPGAPEGGEQERFIPDNNKHNPPASKPAP 311

  Fly   468 ------LKDFPKTVRRQLSNDILMFRTASCVFHLLPIAGLYTFLPKYLETQFRLATYDANMIAAF 526
                  .|||..::::..||.|.:....:.:..:....|:.||.||::|..:..:...|..:...
Zfish   312 VTMSALAKDFLPSLKKLFSNTIYVLLVCTGLIQVSGFIGMITFKPKFMEQVYGQSASRAIFLIGI 376

  Fly   527 CGILVMGIGIVISGLFILKR-KPTARGVAAWIAFTALVYSAGMIILMFIGCSMNDFAGYKPSDGN 590
            ..:..:.:|||..| ||:|| |....|.|......:::....|:|..|:.|..:..||...:...
Zfish   377 MNLPAVALGIVTGG-FIMKRFKVNVLGAAKICIVASVLAFCSMLIQYFLQCDNSQVAGLTVTYQG 440

  Fly   591 SPALIEPT------CSAALNCTCDKENFAPICA-DGKMYISACHAGCSSSSLRPSDNRTLYSDCA 648
            :|.:...|      |:  :.|:|..:::.|||| :|..|.|.|.|||.:|:  ......::.:|:
Zfish   441 APEVSYQTETLISQCN--IGCSCSLKHWDPICASNGVTYTSPCLAGCQTST--GIGKEMVFHNCS 501

  Fly   649 CIPDA------PEAVNGYC--DNNCKNFIY--FILIFAICVFMHSTSEVGSMLLVMRCTHPKDKA 703
            ||.:|      ..||.|.|  .::| :|::  ::.:..|..|..:.......::::|...|:.|:
Zfish   502 CIGEALLPYTNMSAVLGQCPRKSDC-DFMFKIYMAVTVIGAFFSAVGATPGYIILLRSITPELKS 565

  Fly   704 MAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIW-KSVCGKHGACSLYDADTFRQYFLGITAGIMF 767
            :|:|:....:...|.:|.||.:||::|..||.| ...||..|||.:||:..||..|||:...:..
Zfish   566 LALGMHTLIVRTLGGIPPPIYFGALIDKTCLKWGLKQCGGRGACRIYDSGAFRNAFLGLIYALYS 630

  Fly   768 LAFLM-DLVVWRKAHRID--------IAPEDPQEGGPASNGRTLEVSESKQPITPAPDTTV 819
            .::|: .|:..|.:||..        .|||....|...:||.........:  .|..:||:
Zfish   631 SSYLLFGLLYNRLSHREKKQALKDQLKAPEQDSCGVSTTNGNASSAIVKCE--NPDQETTI 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_001163460.1	OATP	175..754	CDD:335235	178/635 (28%)
slco1d1	NP_001335015.1	OATP	16..617	CDD:308646	178/635 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920