DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp74D and Slco5a1

DIOPT Version :9

Sequence 1:	NP_001163460.1	Gene:	Oatp74D / 39954	FlyBaseID:	FBgn0036732	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	XP_008761717.1	Gene:	Slco5a1 / 312907	RGDID:	1307132	Length:	850	Species:	Rattus norvegicus

Alignment Length:	756	Identity:	208/756 - (27%)
Similarity:	337/756 - (44%)	Gaps:	124/756 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 KNGLGNILSSNNNGTGNGHSLSEKYAHEQAPLTGGYKLPPRSSESEESDFDSDLNGGSSAESSSS 156
            |..||:|.:|.:..|..|.:|.  .....||.|..      .:.:|..|.:...:...:...||:
  Rat    57 KLALGSIEASGHQETHPGRNLI--VPSPSAPSTSA------GTTTELMDCNHRRDPSKTVSVSST 113

  Fly   157 CGLFGCRPRWARRFASTHVFMVVFLLAYILQGMYMT-YFVSVITTIEKLFQIKSKTTGILLSASE 220
            ......|.........:..|:|.......:|.:.:: |..|||||||:.:.:||..:|:|:|..:
  Rat   114 LATLQERRCLYVVLTDSRCFLVCMCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFD 178

  Fly   221 MGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQVSPPNN 285
            :|.:...:.::||.|||.||.|:|.|.:|.:|.|...||||||                 |||
  Rat   179 IGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAIGAALFALPHFI-----------------SPP-- 224

  Fly   286 SFSSHWLNASSEQVNPNLCILGGNQT----------HSGSECNEERQLEQASHSKITVIVLCIFF 340
             :....||||:.  |..|| ..||.|          .||..          ||    .|.:.:|.
  Rat   225 -YQIQELNASAS--NDGLC-QNGNSTAILEPPPCPKDSGGN----------SH----WIYVALFV 271

  Fly   341 GSLLSSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRWYVNFSNP 405
            .:.:..|:|.|.:.|||..|:||||....:.:|:|:...|..||||.|::.|.....:||:..||
  Rat   272 CAQVLIGMGSTPIYTLGPTYLDDNVKKDNASLYLAIMYVMGALGPAVGYLLGGLLIGFYVDPRNP 336

  Fly   406 G-FDATDPRWIGAWWLGPVAIGSLMLLASIAMFSFPKQLRGKQKPPGQTATPAAPVEPEEKPK-- 467
            . .|..|||:||.||.|.:.....|.|....||:|||:|..:.|...:.:......:...|.|
  Rat   337 VLLDQNDPRFIGNWWSGFLLCAIAMFLVIFPMFTFPKKLPPRHKKKKKFSADVVSDDDIIKEKSN 401

  Fly   468 -----------------LKDFPKTVRRQLSNDILMFRTASCVFHLLPIAGLYTFLPKYLETQFRL 515
                             ::|.|:...|.|||...:|.:.|.......:....||:||::|:||.:
  Rat   402 TSEQVNKKVSSMGFGKNVRDLPRAAVRILSNMTFLFVSLSYTAESAIVTAFITFIPKFIESQFGI 466

  Fly   516 ATYDANMIAAFCGILVM---GIGIVISGLFILKRKPTARGVAAWIAFTALVYSAGMIILMF---- 573
            ...:|::   :.|::::   |:|||:.|..|.|.|..||..|.    .|::.| |:.:|.|
  Rat   467 PASNASI---YTGVIIVPSAGVGIVLGGYIIKKLKLGARESAK----LAMICS-GVSLLCFSTLF 523

  Fly   574 -IGCSMNDFAGYKPSDGNSPALIEP----TCSAALNCTCDKENFAPIC-ADGKMYISACHAGCSS 632
             :||...:..|........|:|..|    |.|..:||.|....:.|:| :||..|.:.|.|||.:
  Rat   524 IVGCESINLGGINIPYTTGPSLTMPHRNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCIN 588

  Fly   633 SSLRPSDNRTLYSDCACI--------PDAPE------------------AVNGYCDNNCKNFIYF 671
            |....:..|. |::|.|:        |...:                  ||:|.|...|...|.|
  Rat   589 SGNLTTGVRN-YTECTCVQSRQVITPPTVGQRSQLRVVIVKTYLNENGYAVSGKCKRACNTLIPF 652

  Fly   672 ILIFAICVFMHSTSEVGSMLLVMRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIW 736
            ::...|..|:.:.::..::::.:|....:::..|:|:....:.....:|.||.:|||:|:.|::|
  Rat   653 LVFLFIVTFITACAQPSAIIVTLRSVEDEERPFALGMQFVLLRTLAYIPTPIYFGAVIDTTCMLW 717

  Fly   737 KSVCGKHGACSLYDADTFRQYFLGITAGIMFLAFLMDLVVW 777
            :..||..|:|..|:..:||..:.|:.||:.|:.|:...:.|
  Rat   718 QQECGVQGSCWEYNVTSFRFVYFGLAAGLKFVGFIFIFLAW 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_001163460.1	OATP	175..754	CDD:335235	184/648 (28%)
Slco5a1	XP_008761717.1	MFS_SLCO5_OATP5	131..676	CDD:340962	167/590 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810