Protein Alignment Oatp74D and Slco6c1

DIOPT Version :10

• Sequence 1: NP_648989.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_775460.1
• Gene: Slco6c1 / 287006
• RGDID: 708431
• Length: 701
• Species: Rattus norvegicus
• Alignment Length: 745
• Identity: 165/745 - (22%)
• Similarity: 288/745 - (38%)
• Gaps: 153/745 - (20%)

  Fly   119 EQAPLTGGYKLPPRSSESEESDFDSDLNGGSSAESSSSCGL----FGCRPRWARRFASTHVFMVV 179
            :::|.:....|.|:.|.|:|..|                ||    |.|    .:||.:...||:.
  Rat    48 KRSPTSAELLLDPKYSASKEGPF----------------GLGPLVFPC----LQRFNNIDCFMIF 92

  Fly   180 FLLAYILQGMYMTYFVSVITTIEKLFQIKSKT------TGILLSASEMGQICTAMLLTYFAGRGH 238
            |:.:.::.|........::.....|..:..:.      :|.::|:      ..|:.:.:|.|:|:
  Rat    93 FIASVLIHGALFALADMILNLYHSLLTLSKRELYFMDFSGYIVSS------LVAIFVAHFGGKGN 151

  Fly   239 RPRWIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQVSPPNNSFSSHWLNASSEQVNPNL 303
            |.:|||...:|.:..:.....|                          ||.:.:..|..| ...|
  Rat   152 RTKWIAAACILMAFGSILLGFP--------------------------FSKYEIMKSGGQ-RVEL 189

  Fly   304 CILGGNQTHSGSECNEERQLEQASHSK-ITVIVLCIFFGSLLSSGIGQTAVATLGIPYIDDNVGS 367
            |:          |.|:.|.:...::|. .....:|.|......:||....:..||..:|.|:|.:
  Rat   190 CV----------EENKRRNIHCVTNSNPDRTKCICFFIIGQCLNGIAGMPIYILGKTFILDHVPT 244

  Fly   368 KQSPMYMAVTIGMRILGPASGFIFGSFCTRWYVNFSNP---GFDATDPRWIG-----AWWLGPVA 424
            :.:..|:|:.....::|...| |||..     .|.|.|   ...|.|...|.     .||...:.
  Rat   245 RSAGFYLALGHSAHLMGYFLG-IFGGM-----KNLSPPPKEKLSAVDSAKIHLLLQFGWWKTFLF 303

  Fly   425 IGSLMLLASIAMFSFPKQLRG-------KQKPPGQTATPAAPV------EPEEKPKLKDFPKTVR 476
            :.::.....:.:..||..|.|       |:|.|        |.      :.:.:|:.|.|...:.
  Rat   304 VAAISFSVFLVLLCFPTSLPGAHKLKLAKRKEP--------PTFDKRLKDQKIQPRFKGFVFAIW 360

  Fly   477 RQLSNDILMFR-----TASCVFHLLPIAGLYTFLPKYLETQFRLATYDANMIAAFCGILVMGIGI 536
            ..|.|.:||.:     :.|..||.     ...|||.:|:|||.:....|:|:.   |:.|:..|:
  Rat   361 YMLRNPLLMTQAMCKVSESFAFHT-----SLEFLPYHLQTQFSITPQIASMLT---GLFVIPGGV 417

  Fly   537 V---ISGLFILKRKPTARGVAAWIAFTALVYSAGMIILMFIGCSMNDFAGYKPSDGNSPALIEPT 598
            :   :.||.:.:.:.|.:....:...|::|..|..:::.|:.|....|||..........|...|
  Rat   418 IGHFLGGLIVDRLEMTNKNKLKFSLVTSVVSVALFLLIFFVECETTKFAGINEDYDGLGKLGNLT 482

  Fly   599 CSAALNCTCDKENFAPICA-DGKMYISACHAGCSSSSLRPSDNRTLYSDCACI------PDAP-- 654
            .....:|.|....::.:|. |.|.|.|.|.||||::.::  .|...|.:|:||      .||.
  Rat   483 AGCNYHCACTTSLYSSVCGRDEKEYFSPCFAGCSATKVQ--QNEKTYYNCSCIKEGLTTSDADGH 545

  Fly   655 --EAVNGYCDNNCKNF-IYFILIFAICVF--MHSTSEVGSMLLVMRCTHPKDKAMAMGVIQSAIG 714
              :|.:|.|::||... ::|...|:..||  |.||..:   |::::.......::..||..:...
  Rat   546 FIDATDGTCNSNCLTLPLFFAFYFSATVFSTMCSTPII---LIILQSVPANFSSLGQGVTVAITK 607

  Fly   715 LFGNVPCPIIYGAVVDSACLIWK-SVCGKHGACSLYDADTFRQYFLGITAGIMFLAFLMDLVVWR 778
            ...:||.|.::|.....||..|. :.||....|.:|:..|....|:||.........|:::..
  Rat   608 FTASVPEPALFGTASSVACKFWDINACGVREKCWIYNKTTLVYVFIGIWVSFKLFTALLNIYA-- 670

  Fly   779 KAHRIDIAPEDPQEGGPASNGRTLEVSESK 808
             .|..|...:     |..|:.:|..|..||
  Rat   671 -IHIYDYVVK-----GKISDSKTTHVKASK 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_648989.1	OATP	175..754	CDD:460821	139/629 (22%)
Slco6c1	NP_775460.1	MFS	86..588	CDD:475125	126/571 (22%)