Protein Alignment Oatp74D and Slco1b2

DIOPT Version :10

• Sequence 1: NP_648989.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_065241.1
• Gene: Slco1b2 / 28253
• MGIID: 1351899
• Length: 689
• Species: Mus musculus
• Alignment Length: 694
• Identity: 191/694 - (27%)
• Similarity: 307/694 - (44%)
• Gaps: 87/694 - (12%)

  Fly   175 VFMVVFLLAYILQGMYMTYFVSVITTIEKLFQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHR 239
            :|:.....:||.:.:......|.||.||:.|.|.|..:|::....|:|.:...:.::||..:.||
Mouse    27 IFLAALSFSYICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHR 91

  Fly   240 PRWIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQVSPPNNSFSSHWLNASSEQVNPNL- 303
            |:.|..|..:..|.:...|||||..|           ..:.:..|:..|.|         |..|
Mouse    92 PKLIGTGCFIMGIGSILTALPHFFMG-----------YYRYATENDISSLH---------NSTLT 136

  Fly   304 CILGGNQTHSGSECNE---ERQLEQASHSKITVIVLCIFFGSLLSSGIGQTAVATLGIPYIDDNV 365
            |::  |||.|.:..:.   |:..|:.|:|...:.||   .|::| .|||:|.:..||:.||||..
Mouse   137 CLV--NQTTSLTGTSPEIMEKGCEKGSNSYTWIYVL---MGNML-RGIGETPIVPLGVSYIDDFA 195

  Fly   366 GSKQSPMYMAVTIGMRILGPASGFIFGSFCTR-----WYVNFSNPGFDATDPRWIGAWWLGPVAI 425
            ....|.||:.....:.::||..|||..|...:     .||:..:......|.||:||||||.:..
Mouse   196 KEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYVDVGYVDLRSVRITPQDARWVGAWWLGFIVN 260

  Fly   426 GSLMLLASIAMFSFPKQLRGKQKPPGQTAT-----------PAAPVEPEEK---PKLKDFPKTVR 476
            |.|.::.||..|..||..:..||....:|:           |......:||   ..|..|..::|
Mouse   261 GLLCIICSIPFFFLPKIPKRSQKERKNSASLHVLKTDEDKNPVTNPTTQEKQAPANLTGFLWSLR 325

  Fly   477 RQLSNDILMFRTASCVFHLLPIAGLYTFLPKYLETQFRLATYDANMIAAFCGILVMGIGIVISGL 541
            ..|:|:..:......:..:....|.:|:|.|::|.||......||.:.....|..|..|:.:.|.
Mouse   326 SILTNEQYVIFLILTLLQISSFIGSFTYLFKFIEQQFGQTASQANFLLGVITIPTMASGMFLGGY 390

  Fly   542 FILKRKPTARGVAAWIAFT---ALVYSAGMIILMFIGCSMNDFAGYKPS-DGNSPA---LIEPTC 599
            .|.:.|.|..|:..::.||   |.|:.....:|:   |....|||...: ||.:|.   :..|..
Mouse   391 LIKRLKLTLLGITKFVFFTTTMAYVFYLSYFLLI---CENKAFAGLTLTYDGMNPVDSHIDVPLS 452

  Fly   600 SAALNCTCDKENFAPICAD-GKMYISACHAGCSSSSLRPSDNRTL---YSDCACIPDA------P 654
            ....:|.|||..:.|:|.: |..|||.|.|||.|..   .|.:.:   :.||:|:..:      .
Mouse   453 YCNSDCICDKNQWEPVCGENGVTYISPCLAGCKSFR---GDKKLMNIEFYDCSCVSGSGFQKGNH 514

  Fly   655 EAVNGYCD-NNCKNFIYFILIFAICV-FMHSTSEVGSMLLVMRCTHPKDKAMAMGVIQSAIGLFG 717
            .|..|.|. :.||...||.:.|.:.: |..:......||:::|...|:.|::.||.....:...|
Mouse   515 SARLGECPRDKCKTKYYFYITFQVIISFFTALGSTSLMLILIRSVQPELKSLGMGFHSLVVRTLG 579

  Fly   718 NVPCPIIYGAVVDSACLIWK-SVCGKHGACSLYDADTFRQYFLGITAG----IMFLAFLMDLVVW 777
            .:..|:.|||::|..|:.|. :.||..|||.||::..|...::|::..    |:.|...:..|:.
Mouse   580 GILAPVYYGALIDRTCMKWSVTSCGARGACRLYNSRLFGMIYVGLSIALKTPILLLYVALIYVMK 644

  Fly   778 RKAHR-----IDIAPEDPQEGGPA---SNGRTLEVSESKQPITP 813
            ||..|     ::...:...||.|.   :||.:...|:.|...||
Mouse   645 RKMKRNDNKILENGRKFTDEGNPEPVNNNGYSCVPSDEKNSETP 688

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_648989.1	OATP	175..754	CDD:460821	174/621 (28%)
Slco1b2	NP_065241.1	MFS	26..557	CDD:475125	154/561 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	658..689		9/31 (29%)