Protein Alignment Oatp74D and Slco1a4

DIOPT Version :10

• Sequence 1: NP_648989.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_109612.1
• Gene: Slco1a4 / 28250
• MGIID: 1351896
• Length: 670
• Species: Mus musculus
• Alignment Length: 703
• Identity: 197/703 - (28%)
• Similarity: 335/703 - (47%)
• Gaps: 96/703 - (13%)

  Fly   148 GSSAESSSSCGLFGCRPRWARRFASTHVFMVVFLLAYILQGMYMTYFVSVITTIEKLFQIKSKTT 212
            |.|.:..::.|:        |.|:....|::....||:.:.:..||..|::|.||:.|.|.:...
Mouse     2 GKSEKEVATHGV--------RCFSKIKAFLLALTCAYVSKSLSGTYMNSMLTQIERQFGIPTSVV 58

  Fly   213 GILLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQ 277
            |::..:.|:|.:...:.::||..:.|||..|..|..:..:..|..::|||:.|.....::::
Mouse    59 GLINGSFEIGNLLLIIFVSYFGTKLHRPIMIGVGCAVMGLGCFLISIPHFLMGRYEYETTIL--- 120

  Fly   278 TQVSPPNNSFSSHWLNASSEQVNPNLCILGGNQ----THSGSECNEERQLEQASHSKITVIVLCI 338
                 |.::.||          |..:|.....|    |...:||.:|.:         :::.:.:
Mouse   121 -----PTSNLSS----------NSFVCTENRTQTLKPTQDPTECVKEMK---------SLMWIYV 161

  Fly   339 FFGSLLSSGIGQTAVATLGIPYIDDNVGSKQSPMYMAV-TIGMRILGPASGFIFGSFCTRWYVNF 402
            ..|::: .|:|:|.:..|||.||:|...|:.||:|:.: ..||.| ||..|.:.||.|...||:.
Mouse   162 LVGNII-RGMGETPIMPLGISYIEDFAKSENSPLYIGILETGMTI-GPLIGLLLGSSCANIYVDT 224

  Fly   403 SNPGFD-----ATDPRWIGAWWLGPVAIGSLMLLASIAMFSFPKQLRGKQKPPGQTATPAAPVEP 462
            .:...|     .||.||:||||:|.:....:.:|.||..|.|||.|..:........|..|. |.
Mouse   225 GSVNTDDLTITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLLKEGLQDNGDGTENAK-EE 288

  Fly   463 EEKPKLKDFPKTVRRQLSNDILMF-RTASC-----VFHLLPIAGL------YTFLPKYLETQFRL 515
            :.:.|:|:    ..|.::.|..:| ::.||     :|.|:.:..:      :||:|||||.|:..
Mouse   289 KHREKIKE----ENRGITKDFFLFMKSLSCNPIYMIFILISVIQVNAFINSFTFMPKYLEQQYGK 349

  Fly   516 ATYDANMIAAFCGILVMGIGIVISGLFILKRKPTARGVA---AWIAFTALVYSAGMIILMFIGCS 577
            :|.:...:.....:..:.:|.:|.||.:.|.|.|.:..|   .|::.|..:.|   .:...:.|.
Mouse   350 STAEIVFLMGLYMLPPICLGYLIGGLIMKKFKITVKKAAYIGFWLSLTEYLLS---FVSYIMTCD 411

  Fly   578 MNDFAGYKPS-DG-NSPALIEPTCSAALN--CTCDKENFAPICAD-GKMYISACHAGCSSSSLRP 637
            ....||...| :| ..|..:|....|..|  |:|....:.|:|.| |..|:|||.|||..|.  .
Mouse   412 NFPVAGLTTSYEGVQHPLYVENNVLADCNTKCSCLTNTWDPVCGDNGLSYMSACLAGCEKSV--G 474

  Fly   638 SDNRTLYSDCACIPDA--PEAVNGYCDN--NCKNFI-YFILIFAICVFMHSTSEVGSMLLVMRCT 697
            :....::.:|:||..:  ..||.|.||.  .|.|.: ||::|..|..|:.|...:...::::||.
Mouse   475 TGTNMVFQNCSCIQSSGNASAVLGLCDKGPECANKLQYFLIISIIGCFIFSLGAIPGYMVLLRCM 539

  Fly   698 HPKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIWKSV-CGKHGACSLYDADTFRQYFLGI 761
            ..::|::.:|:....:.:.|.:|.||.:||::|..||.|.:: ||:.|||.:||.::||:.:||:
Mouse   540 KSEEKSLGVGLHTFCMRILGGIPAPIYFGALIDRTCLHWGTLKCGEPGACRMYDINSFRRIYLGL 604

  Fly   762 TA---GIMFLAFLMDLVVWRKAH---RIDIAPEDPQEGGPASNGRTLEVSESK 808
            .|   |..||..|..|::.||..   .||.:..||.|       ..|...|||
Mouse   605 PAALRGASFLPALFILILMRKFQFPGDIDSSDTDPAE-------MKLTAKESK 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_648989.1	OATP	175..754	CDD:460821	171/614 (28%)
Slco1a4	NP_109612.1	oat	1..625	CDD:273279	186/669 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	649..670		2/2 (100%)