Protein Alignment Oatp74D and Slco1a1

DIOPT Version :10

• Sequence 1: NP_648989.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_038825.1
• Gene: Slco1a1 / 28248
• MGIID: 1351891
• Length: 670
• Species: Mus musculus
• Alignment Length: 650
• Identity: 197/650 - (30%)
• Similarity: 312/650 - (48%)
• Gaps: 72/650 - (11%)

  Fly   168 RRFASTHVFMVVFLLAYILQGMYMTYFVSVITTIEKLFQIKSKTTGILLSASEMGQICTAMLLTY 232
            |.|:...||::....||:.:.:...|..|::|.||:.|.|.:...|.:..:.|:|.:...:.::|
Mouse    14 RFFSKMKVFLMSLTCAYLAKSLSGVYMNSMLTQIERQFGIPTSVVGFITGSFEIGNLLLIVFVSY 78

  Fly   233 FAGRGHRPRWIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQVSPPNNSFSSHWLNASSE 297
            |..:.|||..|..|.|:..:..|..|.|||:.|.       ...:|.:||.:|..|
Mouse    79 FGRKLHRPIIIGVGCVVMGLGCFLMASPHFLMGR-------YKYETTISPTSNLSS--------- 127

  Fly   298 QVNPNLCILGGNQ----THSGSECNEERQLEQASHSKITVIVLCIFFGSLLSSGIGQTAVATLGI 358
              |..|||....|    |...:||.:|.:         :::.:.:..|:.: .|||:|.:..|||
Mouse   128 --NSFLCIENRTQTLKPTQDPTECVKEIK---------SLMWIYVLIGNTM-RGIGETPIMPLGI 180

  Fly   359 PYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRWYVNFSNPGFD-----ATDPRWIGAW 418
            .||:|...|:.||:|:.:....:|:||..|.:.|||..|.||:..:...|     .||.||:|||
Mouse   181 SYIEDFAKSENSPLYIGILEMGKIVGPIIGLLLGSFFARVYVDIGSVNTDDLTITPTDTRWVGAW 245

  Fly   419 WLGPVAIGSLMLLASIAMFSFPKQLRGKQKPPGQTATPAAPVEP-EEKPK------LKDFPKTVR 476
            |:|.:....:.:|.||..|.|||.|..|:.......|....||. .|:.|      .|||...::
Mouse   246 WIGFLVCAGVNILTSIPFFFFPKTLPKKELQDNVDVTKYEKVEKHRERAKKENLGITKDFLPFMK 310

  Fly   477 RQLSNDILMFRTASCVFHLLPIAGLYTFLPKYLETQFRLATYDANMIAAFCGILVMGIGIVISGL 541
            ....|.|.|..:.:.|..:...|..:||||||||.|:..:|.:|..:.....:..:.:|.:|||.
Mouse   311 SLCCNPIYMLFSLTSVLQINGFASTFTFLPKYLEQQYGKSTSEAVFLIGVYSLPPVCLGYLISGF 375

  Fly   542 FILKRKPTARGVAAWIAFTALVYSAGMIIL--MFIGCSMNDFAG----YK----PSDGNSPALIE 596
            .:.|.|.|.: .||:||| .|..|...|.|  ..:.|.....||    ||    |..|....|.:
Mouse   376 IMKKFKITVK-KAAYIAF-GLSLSEYFIFLCNYLLTCDNFPVAGLTTSYKGVQHPLYGEKNVLAD 438

  Fly   597 PTCSAALNCTCDKENFAPICAD-GKMYISACHAGCSSSSLRPSDNRTLYSDCACIPDA--PEAVN 658
              |:.  .|:|..:.:.|:|.| |..|:|||.|||..|.  .:....::.:|:||..:  ..||.
Mouse   439 --CNT--RCSCLTDTWDPVCGDNGLAYMSACLAGCEKSV--GTGTNMVFQNCSCIGSSGNSSAVL 497

  Fly   659 GYCDN--NCKNFI-YFILIFAICVFMHSTSEVGSMLLVMRCTHPKDKAMAMGVIQSAIGLFGNVP 720
            |.|..  .|.|.: ||::......|:.|.:.:...::::||...::|::.:|:....|.|...:|
Mouse   498 GLCKKGPECDNKLQYFLIKSVFSSFIFSLAAIPGYMVLLRCVKSEEKSIGVGLHAFFIRLLAGIP 562

  Fly   721 CPIIYGAVVDSACLIWKSV-CGKHGACSLYDADTFRQYFLGITA---GIMFLAFLMDLVVWRKAH 781
            .|:.:||::|..||.|.:: ||:.|||.:||.:.||..:||:.|   |..||..:..|::.||.|
Mouse   563 APVYFGALIDRTCLHWGTLKCGQPGACRMYDINRFRHIYLGLPAAVRGSSFLPAVFILILMRKFH 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_648989.1	OATP	175..754	CDD:460821	183/611 (30%)
Slco1a1	NP_038825.1	oat	1..625	CDD:273279	194/646 (30%)