DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp74D and SLCO3A1

DIOPT Version :9

Sequence 1:	NP_001163460.1	Gene:	Oatp74D / 39954	FlyBaseID:	FBgn0036732	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_037404.2	Gene:	SLCO3A1 / 28232	HGNCID:	10952	Length:	710	Species:	Homo sapiens

Alignment Length:	732	Identity:	221/732 - (30%)
Similarity:	341/732 - (46%)	Gaps:	89/732 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 KLPPRSSESEESDFDSDLNGGSSAESSSSCGLFGCRPRWARRFASTHVFMVVFLLAYILQGMYMT 192
            |.|..||....|   .:|.|..:..:........|       |::..:|:|......:.||....
Human     4 KKPGGSSGGGRS---GELQGDEAQRNKKKKKKVSC-------FSNIKIFLVSECALMLAQGTVGA 58

  Fly   193 YFVSVITTIEKLFQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSC 257
            |.|||:||:|:.|.::|...|::.|:.|:|.:...:.::||..||||||.|.||.::.::.|...
Human    59 YLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGALLS 123

  Fly   258 ALPHFIFGEQLMHSSVILQQTQVSPPNNSFSSHWLNASSEQVNPNLCILGGNQTHSGSECNEERQ 322
            |||.|:..:....:..|               .| .|....|    |...|    ||.:...:..
Human   124 ALPEFLTHQYKYEAGEI---------------RW-GAEGRDV----CAANG----SGGDEGPDPD 164

  Fly   323 LEQASHSKITVIVLCIFFGSLLSSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPAS 387
            |...:.:...::.| :..|:.:..|||.|.|..||:.||||:|..|.|.:|:.:...|.:.|||.
Human   165 LICRNRTATNMMYL-LLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPAC 228

  Fly   388 GFIFGSFCTRWYV-----NFSNPGFDATDPRWIGAWWLGPVAIGSLMLLASIAMFSFPKQL---- 443
            |||.|||||:.||     :.||......|||||||||.|.:..|:|:..:|:.||.||:.|
Human   229 GFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMFGFPQSLPPHS 293

  Fly   444 -------------RGKQKPPGQTATPAAPVEPEEK----PKLKDFPKTVRRQLSNDILMFRTASC 491
                         |..::|.........|:||:..    .:|:..||..:..|||.:......:.
Human   294 EPAMESEQAMLSEREYERPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIILAA 358

  Fly   492 VFHLLPIAGLYTFLPKYLETQFRLATYDANMIAAFCGILVMGIGIVISGLFILKRKPTARGVAAW 556
            ...:..:||...||.||||.||.|.|..||.:.....|....:||.:.||.:.|...:|.|....
Human   359 CMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRM 423

  Fly   557 IAFTALVYSAGMIILMFIGCSMNDFAGYKPSDGNSPA---LIEPTCSAALNCTCDKENFAPIC-A 617
            .....||.:|..:..:|:||.....||.....|||.|   .::|......||.|..::|.|:| |
Human   424 AMLVNLVSTACYVSFLFLGCDTGPVAGVTVPYGNSTAPGSALDPYSPCNNNCECQTDSFTPVCGA 488

  Fly   618 DGKMYISACHAGCSSSSLRPSDNRTLYSDCACIPDAP----EAVNGYCDN-NCKN-FIYFILIFA 676
            ||..|:|||.|||:|::|         :.|||:...|    ..|.|.|.: .|:. |:.|:.:..
Human   489 DGITYLSACFAGCNSTNL---------TGCACLTTVPAENATVVPGKCPSPGCQEAFLTFLCVMC 544

  Fly   677 ICVFMHSTSEVGSMLLVMRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIWKSVCG 741
            ||..:.:.::..|:::::|...|:.|:.|:||:...:.|.|.:|.|:|:||.:||.||.|.:.||
Human   545 ICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCLFWSTFCG 609

  Fly   742 KHGACSLYDADTFRQYFLGITAGIMFLAFLMDLVVW---RKAHRIDIAPEDPQEGGPASN---GR 800
            :.|||.|||...:|..::.|...:...||::....|   ||.::..|   ...|||.:::   ..
Human   610 EQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNYKRYI---KNHEGGLSTSEFFAS 671

  Fly   801 TLEVSESKQPITPAPDT 817
            ||.:....:...||..|
Human   672 TLTLDNLGRDPVPANQT 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_001163460.1	OATP	175..754	CDD:335235	196/614 (32%)
SLCO3A1	NP_037404.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		7/23 (30%)
		OATP	41..619	CDD:281175	195/611 (32%)
		MFS	47..>286	CDD:119392	88/263 (33%)
		KAZAL_SLC21	467..511	CDD:238650	20/52 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145462
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750