DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp74D and SLCO4A1

DIOPT Version :9

Sequence 1:	NP_001163460.1	Gene:	Oatp74D / 39954	FlyBaseID:	FBgn0036732	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	XP_011527094.1	Gene:	SLCO4A1 / 28231	HGNCID:	10953	Length:	768	Species:	Homo sapiens

Alignment Length:	721	Identity:	194/721 - (26%)
Similarity:	323/721 - (44%)	Gaps:	105/721 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 SNNNGTGNG--HSLSEKYAHEQAPLTGG-----YKLPPRSSESEESDFDSDLNGGS--------S 150
            |.|:...||  |:...:.|....||:.|     ...|..:|:.......::.:|..        |
Human    15 SPNSAMENGLDHTPPSRRASPGTPLSPGSLRSAAHSPLDTSKQPLCQLWAEKHGARGTHEVRYVS 79

  Fly   151 AESSSSCGLFGCRPRWARRFASTHVFMVVFLLAYILQGMYMTYFV-SVITTIEKLFQIKSKTTGI 214
            |..|.:||.:...|...:...:....:.....|..||||.:..|: :|||::|:.:.:.|..:|:
Human    80 AGQSVACGWWAFAPPCLQVLNTPKGILFFLCAAAFLQGMTVNGFINTVITSLERRYDLHSYQSGL 144

  Fly   215 LLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQ 279
            :.|:.::........::||.|.||:|||:..|::|....:...|||||..|...:.....::...
Human   145 IASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLLMGTGSLVFALPHFTAGRYEVELDAGVRTCP 209

  Fly   280 VSPPNNSFSSHWLNASSEQVNPNLCILGGNQTHSGSECNEERQLEQASHSKITVIVLCIFFGSLL 344
            .:|                               |:.|.:       |.|.::...|....|..|
Human   210 ANP-------------------------------GAVCAD-------STSGLSRYQLVFMLGQFL 236

  Fly   345 SSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRWYVNFSNPGFDA 409
             .|:|.|.:.|||:.|:|:||.|..||:|:|:.....|||||:|::.|......|..........
Human   237 -HGVGATPLYTLGVTYLDENVKSSCSPVYIAIFYTAAILGPAAGYLIGGALLNIYTEMGRRTELT 300

  Fly   410 TD-PRWIGAWWLGPVAIGSLMLLASIAMFSFPKQLRGKQKPPGQTATPAAPVEPEEKPKLK---- 469
            |: |.|:||||:|.:..|:.....::.:..:|:||.|.|:        .|.:...|..:||
Human   301 TESPLWVGAWWVGFLGSGAAAFFTAVPILGYPRQLPGSQR--------YAVMRAAEMHQLKDSSR 357

  Fly   470 ------DFPKTVRRQLSNDILMFRTASCVFHLLP-------IAGLYTFLPKYLETQFRLATYDAN 521
                  ||.||:|....:..|:.:..:.:...|.       |.|:.||.||:||:||.|:..:|
Human   358 GEASNPDFGKTIRDLPLSIWLLLKNPTFILLCLAGATEATLITGMSTFSPKFLESQFSLSASEA- 421

  Fly   522 MIAAFCGILVM---GIGIVISGLFILKRKPTARGVAAWIAFTALVYSAGMIILMFIGCSMNDFAG 583
              |...|.||:   |.|..:.|.|:.|.:.....|..:..|..:|...| |::..:.|.....||
Human   422 --ATLFGYLVVPAGGGGTFLGGFFVNKLRLRGSAVIKFCLFCTVVSLLG-ILVFSLHCPSVPMAG 483

  Fly   584 YKPSDGNS--PA----LIEPTCSAALNCTCDKENFAPIC-ADGKMYISACHAGCSSSSLRPSDNR 641
            ...|.|.|  |.    |..| |:||  |:|..|:::|:| :||.||.|.|||||.:::....|.:
Human   484 VTASYGGSLLPEGHLNLTAP-CNAA--CSCQPEHYSPVCGSDGLMYFSLCHAGCPAATETNVDGQ 545

  Fly   642 TLYSDCACIPD-----APEAVNGYCDNNCKNFIYFILIFAICVFMHSTSEVGSMLLVMRCTHPKD 701
            .:|.||:|||.     ...|..|.|.:.|:.....::...:.:|....|.:.::...:||.....
Human   546 KVYRDCSCIPQNLSSGFGHATAGKCTSTCQRKPLLLVFIFVVIFFTFLSSIPALTATLRCVRDPQ 610

  Fly   702 KAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIWKSVCGKHGACSLYDADTFRQYFLGITAGIM 766
            ::.|:|:....:.:.|.:|.||.:|.|:|.|||:|:..||:.|:|.:|......:|.|  ..|::
Human   611 RSFALGIQWIVVRILGGIPGPIAFGWVIDKACLLWQDQCGQQGSCLVYQNSAMSRYIL--IMGLL 673

  Fly   767 FLAFLM 772
            :.|.|:
Human   674 YKAPLL 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_001163460.1	OATP	175..754	CDD:335235	171/612 (28%)
SLCO4A1	XP_011527094.1	OATP	106..663	CDD:281175	171/610 (28%)
		MFS	106..>489	CDD:119392	115/433 (27%)
		KAZAL_SLC21	500..555	CDD:238650	25/57 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810