Protein Alignment Oatp74D and Slco2a1

DIOPT Version :10

• Sequence 1: NP_648989.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_073158.2
• Gene: Slco2a1 / 24546
• RGDID: 3051
• Length: 644
• Species: Rattus norvegicus
• Alignment Length: 671
• Identity: 199/671 - (29%)
• Similarity: 318/671 - (47%)
• Gaps: 97/671 - (14%)

  Fly   148 GSSAESSSSCGLFGCRPRWARRFASTHVFMVVFLLAYILQGMYMTYFVSVITTIEKLFQIKSKTT 212
            |:|:.....|      ||..  |::..||::...|..:.|.:|..||.|.:|||||.|.:.|.::
  Rat    14 GTSSVPDRRC------PRSV--FSNIKVFVLCHGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSS 70

  Fly   213 GILLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQ 277
            |::.|.:|:......:.::||..|.:|||.|..|.:|.:..||...||||:        |...|.
  Rat    71 GLISSLNEISNATLIIFISYFGSRVNRPRMIGIGGLLLAAGAFVLTLPHFL--------SEPYQY 127

  Fly   278 TQVSPPN-NSFSSHWLNASSEQVNPNLCILGGNQTHSGSECNEERQLEQASHSKITVIVLCIFFG 341
            |..:..| :||.:.........:.|:.|......||.          |.:|...:.|:
  Rat   128 TSTTDGNRSSFQTDLCQKHLPALPPSKCHSTVPDTHK----------ETSSLWGLMVV------- 175

  Fly   342 SLLSSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRWYVNFS--- 403
            :.|.:|||...:...||.|:||......||:|:::...:.:.|||.|::.||...|.:|::.
  Rat   176 AQLLAGIGTVPIQPFGISYVDDFAEPTNSPLYISILFAIAVFGPAFGYLLGSVMLRIFVDYGRVD 240

  Fly   404 ------NPGFDATDPRWIGAWWLGPVAIGSLMLLASIAMFSFPKQL-RGKQKPPGQTATPAAPVE 461
                  :||    |||||||||||.:.....:::.|:..|.||:.: ||.::  ..||......|
  Rat   241 TATVNLSPG----DPRWIGAWWLGLLISSGFLIVTSLPFFFFPRAMSRGAER--SVTAEETMKTE 299

  Fly   462 PEEKPK------LKDFPKTVRRQLSNDILMFRTAS-CVFHLLPIAGLYTFLPKYLETQFRLATYD 519
             |:|.:      :|.||:...|.|.|.:.|....| |.|..: ||||.|||.|:||.|:......
  Rat   300 -EDKSRGSLMDFIKRFPRIFLRLLMNPLFMLVVLSQCTFSSV-IAGLSTFLNKFLEKQYGATAAY 362

  Fly   520 ANMIAAFCGILVMGIGIVISGLFILKR----KPTARGVAAWIAFTALVYSAGMIILMFIGCSMND 580
            ||.:.....:....:|::..|: ::||    ..|...|||.|...:::.   .:.|.|:|||.:.
  Rat   363 ANFLIGAVNLPAAALGMLFGGI-LMKRFVFPLQTIPRVAATIITISMIL---CVPLFFMGCSTSA 423

  Fly   581 FAG-YKPSDGNS-----PALIEPTCSAALNCTCDKENFAPICAD-GKMYISACHAGCSSSSL-RP 637
            .|. |.||..:|     |    |.|..  :|:|....|.|:|.| |..|:|.|||||||::. ..
  Rat   424 VAEVYPPSTSSSIHPQQP----PACRR--DCSCPDSFFHPVCGDNGVEYVSPCHAGCSSTNTSSE 482

  Fly   638 SDNRTLYSDCACIP-DAPEAVNGYCDNNCKNFI---YFILIFAICVFMHSTSEVGSMLLVMRCTH 698
            :....:|.:|:|:. .:..|..|.|..:|...:   .|::.||..:...|.:.:  .::|:|..:
  Rat   483 ASKEPIYLNCSCVSGGSASAKTGSCPTSCAQLLLPSIFLISFAALIACISHNPL--YMMVLRVVN 545

  Fly   699 PKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIWKSVC-GKHGACSLYDADTFRQYFLGI- 761
            ..:|:.|:||....:.|...:|.|.:||.::||:|:.|..:| |:.|||:.||.|..|..:||:
  Rat   546 QDEKSFAIGVQFLLMRLLAWLPAPSLYGLLIDSSCVRWNYLCSGRRGACAYYDNDALRNRYLGLQ 610

  Fly   762 ----TAGIMFLAFLMDLVVWR 778
                ..|.:.|.|    :.||
  Rat   611 MVYKALGTLLLFF----ISWR 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_648989.1	OATP	175..754	CDD:460821	185/613 (30%)
Slco2a1	NP_073158.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		2/5 (40%)
		MFS_SLCO2A_OATP2A	30..542	CDD:341019	163/556 (29%)