DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp74D and Slco5a1

DIOPT Version :9

Sequence 1:	NP_001163460.1	Gene:	Oatp74D / 39954	FlyBaseID:	FBgn0036732	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_766429.2	Gene:	Slco5a1 / 240726	MGIID:	2443431	Length:	850	Species:	Mus musculus

Alignment Length:	767	Identity:	208/767 - (27%)
Similarity:	339/767 - (44%)	Gaps:	153/767 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 EESDFDSDLNGGSSAESSSSCG----LFGCRPRW----------------ARR-----FASTHVF 176
            :|:....:|...|.:..|:|.|    |..|..|.                .||     ...:..|
Mouse    69 QETHLGRNLIVPSPSAPSTSAGTTTELMDCNHRMDPSKTVSVSSTLATLQERRCLYVVLTDSRCF 133

  Fly   177 MVVFLLAYILQGMYMT-YFVSVITTIEKLFQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHRP 240
            :|.......:|.:.:: |..|||||||:.:.:||..:|:|:|..::|.:...:.::||.|||.||
Mouse   134 LVCMCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRP 198

  Fly   241 RWIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQVSPPNNSFSSHWLNASSEQVNPNLCI 305
            .|:|.|.:|.:|.|...||||||                 |||   :....||||:.  |..||
Mouse   199 LWLAVGGLLIAIGAALFALPHFI-----------------SPP---YQIQELNASAS--NDGLC- 240

  Fly   306 LGGNQT----------HSGSECNEERQLEQASHSKITVIVLCIFFGSLLSSGIGQTAVATLGIPY 360
            ..||.|          .||..          ||    .|.:.:|..:.:..|:|.|.:.|||..|
Mouse   241 QNGNSTAILEPPPCPKDSGGN----------SH----WIYVALFVCAQVLIGMGSTPIYTLGPTY 291

  Fly   361 IDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRWYVNFSNP-GFDATDPRWIGAWWLGPVA 424
            :||||....:.:|:|:...|..||||.|::.|.....:||:..|| ..|.:|||:||.||.|.:.
Mouse   292 LDDNVKKDNASLYLAIMYVMGALGPAVGYLLGGLLIGFYVDPRNPVHLDQSDPRFIGNWWSGFLL 356

  Fly   425 IGSLMLLASIAMFSFPKQL--RGKQKPP------------GQTATPAAPVEPEEKP-----KLKD 470
            ....|.|....||:|||:|  |.|:|..            .:.:..:..:..:..|     .::|
Mouse   357 CAIAMFLVIFPMFTFPKKLPPRHKKKKKFSADVVIDDDIIKEKSNTSEQMNKKVSPMGFGKNVRD 421

  Fly   471 FPKTVRRQLSNDILMFRTASCVFHLLPIAGLYTFLPKYLETQFRLATYDANMIAAFCGILVM--- 532
            .|:...|.|||...:|.:.|.......:....||:||::|:||.:...:|::   :.|::::
Mouse   422 LPRAAVRILSNMTFLFVSLSYTAESAIVTAFITFIPKFIESQFGIPASNASI---YTGVIIVPSA 483

  Fly   533 GIGIVISGLFILKRKPTARGVAAWIAFTALVYSAGMIILMF-----IGCSMNDFAGYKPSDGNSP 592
            |:|||:.|..|.|.|..||..|.    .|::.| |:.:|.|     :||...:..|........|
Mouse   484 GVGIVLGGYIIKKLKLGARESAK----LAMICS-GVSLLCFSTLFIVGCESINLGGINIPYTTGP 543

  Fly   593 ALIEP----TCSAALNCTCDKENFAPIC-ADGKMYISACHAGCSSSSLRPSDNRTLYSDCACI-- 650
            :|..|    |.|..:||.|....:.|:| :||..|.:.|.|||.:|....:..|. |::|.|:
Mouse   544 SLTMPHRNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCINSGNLTTGVRN-YTECTCVQS 607

  Fly   651 ------PDAPE------------------AVNGYCDNNCKNFIYFILIFAICVFMHSTSEVGSML 691
                  |...:                  ||:|.|...|...|.|::...|..|:.:.::..:::
Mouse   608 RQVITPPTVGQRSQLRVVIVKTYLNENGYAVSGKCKRTCNTLIPFLVFLFIVTFITACAQPSAII 672

  Fly   692 LVMRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIWKSVCGKHGACSLYDADTFRQ 756
            :.:|....:::..|:|:....:.....:|.||.:|||:|:.|::|:..||..|:|..|:..:||.
Mouse   673 VTLRSVEDEERPFALGMQFVLLRTLAYIPTPIYFGAVIDTTCMLWQQECGVQGSCWEYNVTSFRF 737

  Fly   757 YFLGITAGIMFLAFLMDLVVW------------RKAHRIDIAPEDPQEGGPA 796
            .:.|:.||:.|:.|:...:.|            |:.....::....|.|.|:
Mouse   738 VYFGLAAGLKFVGFIFIFLAWYSIKYKEDGLQRRRCREFPLSTVSEQVGQPS 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_001163460.1	OATP	175..754	CDD:335235	185/648 (29%)
Slco5a1	NP_766429.2	MFS_SLCO5_OATP5	131..676	CDD:340962	168/590 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810