Protein Alignment Oatp74D and Slco2a1

DIOPT Version :10

• Sequence 1: NP_648989.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_201571.2
• Gene: Slco2a1 / 24059
• MGIID: 1346021
• Length: 643
• Species: Mus musculus
• Alignment Length: 659
• Identity: 198/659 - (30%)
• Similarity: 318/659 - (48%)
• Gaps: 99/659 - (15%)

  Fly   167 ARR-----FASTHVFMVVFLLAYILQGMYMTYFVSVITTIEKLFQIKSKTTGILLSASEMGQICT 226
            |||     |.:..||::...|..:.|.:|..||.|.:|||||.|.:.|.::|::.|.:|:.....
Mouse    20 ARRCSRSVFNNIKVFVLCHGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAIL 84

  Fly   227 AMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQVSPPNNSFSSHW 291
            .:.::||..|.:|||.|..|.:|.:..||...||||:        |...|....:..|   |||:
Mouse    85 IIFVSYFGSRVNRPRMIGIGGLLLAAGAFVLTLPHFL--------SEPYQYASTTAGN---SSHF 138

  Fly   292 LNASSEQVNPNLCILGGNQTH----SGSECNE---ERQLEQASHSKITVIVLCIFFGSLLSSGIG 349
                    ..:||     |.|    ..|:|:.   :.|.|.:|...:.|:       :.|.:|:|
Mouse   139 --------QTDLC-----QKHLPGLLPSKCHSTVPDTQKETSSMWSLMVV-------AQLLAGVG 183

  Fly   350 QTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRWYVNFS---------NP 405
            ...:...||.|:||......||:|:::...:.:.|||.|::.||...|.:|::.         :|
Mouse   184 TVPIQPFGISYVDDFAEPTNSPLYISILFAIAVFGPAFGYLLGSVMLRIFVDYGRVDTATVNLSP 248

  Fly   406 GFDATDPRWIGAWWLGPVAIGSLMLLASIAMFSFPKQL-RGKQKPPGQTATPAAPVEPEEKPK-- 467
            |    |||||||||||.:.....:::.|:..|.||:.: ||.::  ...|.....:| |:|.:
Mouse   249 G----DPRWIGAWWLGLLISSGFLIVTSLPFFFFPRAMSRGAER--SVIAEETMKME-EDKSRGS 306

  Fly   468 ----LKDFPKTVRRQLSNDILMFRTAS-CVFHLLPIAGLYTFLPKYLETQFRLATYDANMIAAFC 527
                :|.||:...|.|.|.:.|....| |.|..: ||||.|||.|:||.|:..:...||::....
Mouse   307 LMDFIKRFPRIFLRLLMNPLFMLVVLSQCTFSSV-IAGLSTFLNKFLEKQYDASAAYANLLIGAV 370

  Fly   528 GILVMGIGIVISGLFILKR----KPTARGVAAWIAFTALVYSAGMIILMFIGCSMNDFAG-YKPS 587
            .:....:|::..|: ::||    ..|...|||.|...:::..|.   |.|:|||....|. |.||
Mouse   371 NLPAAALGMLFGGI-LMKRFVFPLQTIPRVAATIMTISIILCAP---LFFMGCSTPAVAEVYPPS 431

  Fly   588 DGNSPALIEPTCSAA-LNCTCDKENFAPICAD-GKMYISACHAGCSSSSL-RPSDNRTLYSDCAC 649
               :|:.|.|...|. .:|.|....|.|:|.| |..|:|.|||||||.:: ..:..:.:|.:|:|
Mouse   432 ---TPSSIHPQPPACRRDCLCPDSVFHPVCGDNGVEYLSPCHAGCSSLNVSSAASKQPIYLNCSC 493

  Fly   650 IP-DAPEAVNGYCDNNCKNFI---YFILIFAICVFMHSTSEVGSMLLVMRCTHPKDKAMAMGVIQ 710
            :. .:..|..|.|..:|...:   .|::.|...:...|.:.:  .::|:|..:..:|:.|:||..
Mouse   494 VTGGSASAKTGSCPTSCAQLLLPSIFLISFVALIACVSHNPL--YMMVLRVVNQDEKSFAIGVQF 556

  Fly   711 SAIGLFGNVPCPIIYGAVVDSACLIWKSVC-GKHGACSLYDADTFRQYFLGI-----TAGIMFLA 769
            ..:.|...:|.|.:||.::||:|:.|..:| |:.|||:.||.|..|..:||:     ..|.:.|.
Mouse   557 LLMRLLAWLPSPSLYGLLIDSSCIRWNYLCSGRRGACAYYDNDALRNRYLGLQVIYKVLGTLLLF 621

  Fly   770 FLMDLVVWR 778
            |    :.||
Mouse   622 F----ISWR 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_648989.1	OATP	175..754	CDD:460821	186/615 (30%)
Slco2a1	NP_201571.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		198/659 (30%)
		MFS_SLCO2A_OATP2A	30..541	CDD:341019	164/558 (29%)