Protein Alignment Oatp74D and Y70G10A.3

DIOPT Version :10

• Sequence 1: NP_648989.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_499267.1
• Gene: Y70G10A.3 / 190573
• WormBaseID: WBGene00013499
• Length: 690
• Species: Caenorhabditis elegans
• Alignment Length: 687
• Identity: 176/687 - (25%)
• Similarity: 294/687 - (42%)
• Gaps: 111/687 - (16%)

  Fly   157 CGLFGCRPRWARRFASTHVFMVVF-LLAYILQGMYMTYFVSVITTIEKLFQIKSKTTGILLSASE 220
            ||...|.|.|.:.|.:....:||. :.|:|...:....|...::|:|:.|::.|..|||:.|..:
 Worm    31 CGYGACTPSWLQGFHNAKCLLVVLGICAFIQSFVVNAIFPVGLSTLERRFKMTSTHTGIISSWYD 95

  Fly   221 MGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQVSPPNN 285
            ...:.....:.::...||:.|||..|.|:.::.:..|||||::.  .:.|           |..|
 Worm    96 FAVLLVVFPVCHWGNNGHKGRWIGWGGVIMALGSLICALPHWMV--DIYH-----------PDVN 147

  Fly   286 SFSSHWLNASSEQVNPNLCILGGNQTHSGSECN-EERQLEQASHSKITVIVLCIFFGSLLSSGIG 349
            ..:                    |||..|...| ::.:.....||........:|.......|:|
 Worm   148 DLT--------------------NQTDFGQCANRDDPECAGKPHSSWFNPYFWMFILGQTLHGVG 192

  Fly   350 QTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRWYVNFSN----PGFDAT 410
            .|.:.::|..|:|:||..|.||:|:|:...:...||..|...|.|....|.:|..    | .:.:
 Worm   193 STPLFSIGTTYMDENVSQKASPVYLAIHAVLTSFGPVIGVFAGGFLLNLYDDFDRVERIP-MERS 256

  Fly   411 DPRWIGAWWLGPV--AIGSLMLLASIAMFS--FPKQLRGKQKPPGQTATPAAPVEPEEKPKLKDF 471
            ||||:||||:|.:  :|.:||:...|..|:  .|:..|.:.|...|.......|..:....|...
 Worm   257 DPRWVGAWWVGFIISSISALMIAFPILAFARELPEAKRHRAKDVNQCHVANGDVNAKAPRDLMKL 321

  Fly   472 PKTVRRQLSNDILMFRTASCVFHLLPIAGLYTFLPKYLETQF----RLATYDANMIAAFCGILVM 532
            |..|.:.|||...:......:|..:.|.|...|:||.|||..    .||:|.::::     |...
 Worm   322 PACVWKILSNPTFLVCIFVGIFESIIINGFAAFMPKILETLLSTNPTLASYLSSVV-----IFAA 381

  Fly   533 GIGIVISGLFILKRKPTARGVAAWIAFT---ALVYSAGMII----LMFIGCS----------MND 580
            ..|:::.|..|.:.|....|:...|...   ||:::.|::.    ..|:|.:          |:|
 Worm   382 ATGVMVGGTIIRQLKLQVGGMLKMIIVCHVFALLFTTGLLSHCPQREFVGINLGYEDLSIEKMHD 446

  Fly   581 FAGYKPSDGNSPALIEPTCSAALNCTCDKENFAPIC--ADGKMYISACHAGCSSSSLRPSDNRTL 643
            |:            |..||:|  :|.| |..:.|:|  ..|.||.|||||||:..:  ..|..:.
 Worm   447 FS------------ISSTCNA--DCHC-KMEWNPVCDRNTGHMYYSACHAGCTGRT--TIDGSSQ 494

  Fly   644 YSDCAC-------------IPDAPEAVN-GYCDNNC--KNFIYFILIFAICVFMHSTSEVGSMLL 692
            :|.|.|             |.:.|:.:| |||..:|  :.:|..:.:| |.|.....|.:.:..:
 Worm   495 WSGCGCLTSNSTFHNLIHGIKEHPDVLNQGYCHQDCGYREYILMVTLF-ITVVASFASGIPTQQI 558

  Fly   693 VMRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIWKSVCGKHGACSLYDADTFRQY 757
            ::|......:.:|:||..:.:.|.|.:|..|::|.::|:|||.|...|||..:|.:||.......
 Worm   559 MLRVVPFDQRTLALGVNWTFVRLLGFIPGGILFGIIIDTACLEWGESCGKATSCLVYDPFKLSWT 623

  Fly   758 FLGITAGIMFLAFLMDLVVWRKAHRIDIAPEDPQEGG 794
            ..|:......|:.|..::.:     :...|.|....|
 Worm   624 ITGLAIVCKLLSILATIIGY-----MTYRPSDLDNAG 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_648989.1	OATP	175..754	CDD:460821	164/627 (26%)
Y70G10A.3	NP_499267.1	MFS_SLCO4_OATP4	47..561	CDD:340961	144/570 (25%)