DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp74D and Y70G10A.3

DIOPT Version :9

Sequence 1:	NP_001163460.1	Gene:	Oatp74D / 39954	FlyBaseID:	FBgn0036732	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_499267.1	Gene:	Y70G10A.3 / 190573	WormBaseID:	WBGene00013499	Length:	690	Species:	Caenorhabditis elegans

Alignment Length:	687	Identity:	176/687 - (25%)
Similarity:	294/687 - (42%)	Gaps:	111/687 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 CGLFGCRPRWARRFASTHVFMVVF-LLAYILQGMYMTYFVSVITTIEKLFQIKSKTTGILLSASE 220
            ||...|.|.|.:.|.:....:||. :.|:|...:....|...::|:|:.|::.|..|||:.|..:
Worm    31 CGYGACTPSWLQGFHNAKCLLVVLGICAFIQSFVVNAIFPVGLSTLERRFKMTSTHTGIISSWYD 95

  Fly   221 MGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQVSPPNN 285
            ...:.....:.::...||:.|||..|.|:.::.:..|||||::.  .:.|           |..|
Worm    96 FAVLLVVFPVCHWGNNGHKGRWIGWGGVIMALGSLICALPHWMV--DIYH-----------PDVN 147

  Fly   286 SFSSHWLNASSEQVNPNLCILGGNQTHSGSECN-EERQLEQASHSKITVIVLCIFFGSLLSSGIG 349
            ..:                    |||..|...| ::.:.....||........:|.......|:|
Worm   148 DLT--------------------NQTDFGQCANRDDPECAGKPHSSWFNPYFWMFILGQTLHGVG 192

  Fly   350 QTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRWYVNFSN----PGFDAT 410
            .|.:.::|..|:|:||..|.||:|:|:...:...||..|...|.|....|.:|..    | .:.:
Worm   193 STPLFSIGTTYMDENVSQKASPVYLAIHAVLTSFGPVIGVFAGGFLLNLYDDFDRVERIP-MERS 256

  Fly   411 DPRWIGAWWLGPV--AIGSLMLLASIAMFS--FPKQLRGKQKPPGQTATPAAPVEPEEKPKLKDF 471
            ||||:||||:|.:  :|.:||:...|..|:  .|:..|.:.|...|.......|..:....|...
Worm   257 DPRWVGAWWVGFIISSISALMIAFPILAFARELPEAKRHRAKDVNQCHVANGDVNAKAPRDLMKL 321

  Fly   472 PKTVRRQLSNDILMFRTASCVFHLLPIAGLYTFLPKYLETQF----RLATYDANMIAAFCGILVM 532
            |..|.:.|||...:......:|..:.|.|...|:||.|||..    .||:|.::::     |...
Worm   322 PACVWKILSNPTFLVCIFVGIFESIIINGFAAFMPKILETLLSTNPTLASYLSSVV-----IFAA 381

  Fly   533 GIGIVISGLFILKRKPTARGVAAWIAFT---ALVYSAGMII----LMFIGCS----------MND 580
            ..|:::.|..|.:.|....|:...|...   ||:::.|::.    ..|:|.:          |:|
Worm   382 ATGVMVGGTIIRQLKLQVGGMLKMIIVCHVFALLFTTGLLSHCPQREFVGINLGYEDLSIEKMHD 446

  Fly   581 FAGYKPSDGNSPALIEPTCSAALNCTCDKENFAPIC--ADGKMYISACHAGCSSSSLRPSDNRTL 643
            |:            |..||:|  :|.| |..:.|:|  ..|.||.|||||||:..:  ..|..:.
Worm   447 FS------------ISSTCNA--DCHC-KMEWNPVCDRNTGHMYYSACHAGCTGRT--TIDGSSQ 494

  Fly   644 YSDCAC-------------IPDAPEAVN-GYCDNNC--KNFIYFILIFAICVFMHSTSEVGSMLL 692
            :|.|.|             |.:.|:.:| |||..:|  :.:|..:.:| |.|.....|.:.:..:
Worm   495 WSGCGCLTSNSTFHNLIHGIKEHPDVLNQGYCHQDCGYREYILMVTLF-ITVVASFASGIPTQQI 558

  Fly   693 VMRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIWKSVCGKHGACSLYDADTFRQY 757
            ::|......:.:|:||..:.:.|.|.:|..|::|.::|:|||.|...|||..:|.:||.......
Worm   559 MLRVVPFDQRTLALGVNWTFVRLLGFIPGGILFGIIIDTACLEWGESCGKATSCLVYDPFKLSWT 623

  Fly   758 FLGITAGIMFLAFLMDLVVWRKAHRIDIAPEDPQEGG 794
            ..|:......|:.|..::.:     :...|.|....|
Worm   624 ITGLAIVCKLLSILATIIGY-----MTYRPSDLDNAG 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_001163460.1	OATP	175..754	CDD:335235	164/627 (26%)
Y70G10A.3	NP_499267.1	OATP	49..620	CDD:281175	164/627 (26%)
		MFS	51..>421	CDD:119392	104/408 (25%)
		KAZAL_SLC21	449..500	CDD:238650	22/55 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810