Protein Alignment Oatp74D and F53B1.8

DIOPT Version :10

• Sequence 1: NP_648989.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_001294793.1
• Gene: F53B1.8 / 180528
• WormBaseID: WBGene00018739
• Length: 801
• Species: Caenorhabditis elegans
• Alignment Length: 818
• Identity: 202/818 - (24%)
• Similarity: 350/818 - (42%)
• Gaps: 155/818 - (18%)

  Fly    74 STPSNNNEWKAPEDLGHLKNGLGNILSSNNNGTGNGHSLSEKYAHEQAPLTGGYKLPPRSSESEE 138
            |:....|:|      .|::..        :.|....|.       |:|.....::|||:..|..|
 Worm    31 SSKPTRNKW------SHMRQA--------SQGVPPRHM-------EKALRRKEFQLPPQQHELIE 74

  Fly   139 SDFDSDLNGGSSAESSSSCGLFGCRPRWARRFASTHVFMVVFLLAYI-LQGMYMTYFV-SVITTI 201
            .:.       :.....|.||:...||:|.:.... .:.|:|.|..|. :||:.:...| |.|::|
 Worm    75 REM-------TVLTEESQCGIGKWRPKWLQCLGK-QLPMIVLLCVYCSIQGLIVNGLVPSAISSI 131

  Fly   202 EKLFQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALPHFIFGE 266
            |:.|:..:...|.::...:.|.:...:.::||.||..:|..:|.|:...::.:...:.||
 Worm   132 ERRFKFSTSHMGRIVQFYDFGYVLLCIPVSYFGGRHSKPAVLAAGLACMALGSLIFSAPH----- 191

  Fly   267 QLMHSSVILQQTQVSPPNNSFSS----HWLNASSEQVNPNLCILGGNQTHSGSECNEERQLEQAS 327
             :|..|....|:     |.||.:    |.|  .::..:|        :..:..:|..|.| :|.|
 Worm   192 -IMSDSYSASQS-----NMSFGTCSIEHLL--QNDMTSP--------EALAQIQCQSENQ-DQHS 239

  Fly   328 HSKITVIVLCIFFGSLLSSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFG 392
            .|.:...:.|  |...| .|||.|.:.|:|:.|||:|||:.:|.:::.:.....:.|||.||:..
 Worm   240 SSNLYFYLFC--FAHFL-HGIGATPLFTIGVSYIDENVGTAKSSLFVGIFYSFAVFGPAIGFLGA 301

  Fly   393 SFCTRWYVNF--------SNPGFDATDPRWIGAWWLGPVAIGSLMLLASIAMFSFPKQLRGKQK- 448
            |...:::.:|        .......|||.|:|||||..:|...:..:|.:.:.|.||.|....|
 Worm   302 SVSLQYHTDFWHLPPEQILKVSSGETDPTWVGAWWLSFIAASFVGFVAVLPLASLPKVLPASLKW 366

  Fly   449 ---------------------PPGQTATPA----APVEPEEK------------P-------KLK 469
                                 .||...|.|    ||:..:..            |       .::
 Worm   367 HRSRLHDAAVANRRRTPECCGMPGSNKTAALNSDAPMAEQASLLYSSIPARGRGPLWYKIWLDVR 431

  Fly   470 DFPKTVRRQLSNDILMFRTASCVFHLLPIAGLYTFLPKYLETQFRLATYDANMIAAFCGILVMGI 534
            ..|..:.|.|:|.:.|..|::.....|.:.|..:|:.||||.||.:....||::.....:.:.|:
 Worm   432 HIPIAIYRILTNWLFMIITSAMAIDSLVVTGASSFMSKYLERQFSVRPSKANLLIGCVMVPMAGM 496

  Fly   535 GIVISG----LFILKRKPTARGVAAWIAFTALVYSAGMII------LMFIGCSMNDFAGYKPSDG 589
            |.:::|    .|.|......: .|..:.|.:|::|...:|      |:.:..:..:|.|..| |.
 Worm   497 GCMVTGGIVNHFRLNSSKMLK-FAIGLIFLSLLFSPMYLIYCPHAPLVGVDSAYPEFDGSIP-DY 559

  Fly   590 NSPALIEPTCSAALN--CTCDKENFAPICA---DGKM--YISACHAGCS---SSSLRPSDNRTLY 644
            |:....:|....:.|  ||||...:.|:||   ||:.  |.|.|:||||   |:||:.      |
 Worm   560 NATYSKDPELMNSCNKQCTCDPSEYRPVCAELDDGRQFTYYSPCYAGCSETYSASLKE------Y 618

  Fly   645 SDCACIP----DAPEAV-NGYCDNNCKNFIYFILIFAICVFMHSTSEVGSMLLVMRCTHPKDKAM 704
            ::|:|:|    :.|..| .|.|:..|...::|:|:||...|......|..:.:::|.....:::.
 Worm   619 TECSCVPTNTKNRPRIVKKGVCEPQCTELLWFLLLFAPLSFCTFAIAVPIISVILRTVDYNERSF 683

  Fly   705 AMGVIQSAIGLFGNVPCPIIYGAVVDSACLIWKS-VCG-KHGACSLYDADTFRQYFLGITAG--I 765
            |:|:....|.:.|.:|.|:::|.:.|.:|:.::| .|| ..|.|.:|........||..|..  |
 Worm   684 ALGIQWIMIRVIGTIPAPVLFGWMFDVSCIKYQSDSCGSSSGGCLMYSNQYLANLFLTFTISGQI 748

  Fly   766 MFLAFLMDLVVWRKAHRIDIAPEDPQEGGPASNGRTLE 803
            :.||.|:.:::...|     |..|....||.:....||
 Worm   749 ITLAILIVVLMIFGA-----ALNDDANHGPPTGDHQLE 781

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_648989.1	OATP	175..754	CDD:460821	169/664 (25%)
F53B1.8	NP_001294793.1	oat	72..763	CDD:273279	183/731 (25%)