DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp74D and Y32F6B.1

DIOPT Version :9

Sequence 1:	NP_001163460.1	Gene:	Oatp74D / 39954	FlyBaseID:	FBgn0036732	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_505689.2	Gene:	Y32F6B.1 / 179463	WormBaseID:	WBGene00012531	Length:	760	Species:	Caenorhabditis elegans

Alignment Length:	756	Identity:	201/756 - (26%)
Similarity:	321/756 - (42%)	Gaps:	137/756 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 FMVVFLLAYILQ---GMYMTYFVSVITTIEKLFQIKSKTTGILLSASEMGQICTAMLLTYFAGRG 237
            |.:||...|.|:   |.|||   |.:..|||.|||.|:.:|.::||.:...|...:..:||.|:|
Worm     9 FFIVFGTVYFLESIGGFYMT---SAVVFIEKQFQIPSRLSGTMVSAGDFAYIPVVIFTSYFGGKG 70

  Fly   238 HRPRWIACGMVLFSIAAFSCALPHFIFG-EQ----------LMHSSVILQQTQVSPPNNSFSSHW 291
            :|.|||..|.:|.:||.|..|..:|:|. ||          |.|.   :.:..|:...||....|
Worm    71 NRARWIGAGCILIAIANFMIASSNFLFPVEQANVTTHIPSALAHQ---IDRDIVNGDVNSTEHLW 132

  Fly   292 LNASSEQVNP-----NLCILG--GNQT-------------HSGSE-------------------- 316
            |    ||::|     |..::.  |::.             |.|||
Worm   133 L----EQIHPLIDPKNQVVMNYEGDEKSDLLQKYVEYCHYHKGSEICKNLEKYIAEKFPITDAKM 193

  Fly   317 -------------CNEERQLEQASH-----SKITVIVLCIFFGSLLSSGIGQTAVATLGIPYIDD 363
                         |:......:|.|     .:.|:....:.||.||..|:|:|...:||:|.:||
Worm   194 SNVRAMVALPYGFCHSMLNFVRAQHYACKKDQSTLGPFMMIFGGLLVLGVGRTMPFSLGLPLMDD 258

  Fly   364 NVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRWYVNFSNP-GFDATDPRWIGAWWLGPVAIGS 427
            ||..:..|:|.:....::||||..|.:.|....:.||:|:.| |....||.|||.||||.:..|:
Worm   259 NVKKQNLPLYFSFMFFVKILGPVIGLLVGGQLNKLYVDFNPPQGLTPLDPMWIGCWWLGFLIFGT 323

  Fly   428 LMLLASIAMFSFPK-----------QLRGKQKPPGQTATPAAPVEPEEK----------PKLKDF 471
            |:...|:.::.||.           ...||.||..:.......::.:|:          .|:.||
Worm   324 LLFGPSLVLYFFPSDDLDINAPEEFDDDGKVKPRKRLNLVDRHIKKDEQGNALMPETIMDKINDF 388

  Fly   472 PKTVRRQLSNDILMFRTASCVFHLLPIAGLYTFLPKYLETQFRLATYDANMIAAFCGILVMGIGI 536
            ..|:...:.|.|.:......:..:|...|.:.|..||||.||.:..|......|..||:....|:
Worm   389 KATIANLVKNKIFVGAMFGRIIDVLAFKGYFVFQAKYLELQFGVPQYRIQRYIASTGIVGFACGV 453

  Fly   537 VISGLFILKRKPTARGVAAWIAFTALVYSAGMIILMFIGCSMNDFAGYKPSDG--------NSPA 593
            ::..|.:...|...|..|||:|..:||.:    ::.|    .|...|.|...|        |.|
Worm   454 ILGSLSMKFLKLQGRKAAAWVAVCSLVAA----LISF----ANGTVGCKSVIGQIGDQIKINGP- 509

  Fly   594 LIEPTCSAALNCTCDKENFAPIC-ADGKMYISACHAGCSS--------SSLRPSDNRTLYSDCAC 649
             :...|..  :|.|::....|:| ..|..|.|.|||||:.        .:.:.:.:..::.:|||
Worm   510 -VFDGCRD--DCMCEQTPLYPVCDVSGSAYYSPCHAGCAMGWKNYSIFDNTKATVDTLIFENCAC 571

  Fly   650 IPD-APEAVNGYC-DNNC-KNFIYFILIFAICVFMHSTSEVGSMLLVMRCTHPKDKAMAMGVIQS 711
            :.: ..|....|| ...| :.|..|.:..|..........|..||:|:|...|:.:::::|....
Worm   572 VDNKVKEVSRSYCRTEECEERFGRFFMHQAFGAVFGGLGVVPGMLIVLRAVPPEHRSVSLGFNGF 636

  Fly   712 AIGLFGNVPCPIIYGAVVDSACLIWKSVCGKHGACSLYDADTFRQYFLGITAGIMFLAFLMDLVV 776
            .:.|...:|.|||:|.::|.:||:||..|...|:||:||.|..|.....|...:...:.:.|:.|
Worm   637 LVSLLATLPSPIIWGKIIDMSCLLWKKSCDSSGSCSVYDTDELRVRLHVIYGCLRIFSLISDVWV 701

  Fly   777 WRKAHRIDIAPEDPQEGGPASNGRTLEV-SESKQPITPAPD 816
            |..|..:.:..|:..|........|.:: |:.|:.:..|.:
Worm   702 WYWARGLKLIEEETPEDKDKKEEETEKLHSKRKESLRDAAE 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_001163460.1	OATP	175..754	CDD:335235	189/691 (27%)
Y32F6B.1	NP_505689.2	oat	4..706	CDD:273279	194/718 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158577
Domainoid	1	1.000	308	1.000	Domainoid score	I730
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H80422
Inparanoid	1	1.050	324	1.000	Inparanoid score	I1469
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28658
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	1	1.000	-	-		FOG0014327
OrthoInspector	1	1.000	-	-		mtm4773
orthoMCL	1	0.900	-	-		OOG6_108756
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3798
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.670