DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp74D and Slco6b1

DIOPT Version :9

Sequence 1:	NP_001163460.1	Gene:	Oatp74D / 39954	FlyBaseID:	FBgn0036732	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_596903.1	Gene:	Slco6b1 / 170925	RGDID:	620278	Length:	748	Species:	Rattus norvegicus

Alignment Length:	825	Identity:	182/825 - (22%)
Similarity:	303/825 - (36%)	Gaps:	172/825 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 DSSQAFTPLLSQHN------NGTTNG--EVTTPPPSTV---------------------LYESTP 76
            :..||.|....:.|      |.||..  ::||..|..:                     :..|..
  Rat     6 EQRQASTAKARKDNTLEAPVNITTEAPVDITTEAPVDITAQAPVDITAEALADITAEAWMDSSAE 70

  Fly    77 SNNNEWKAPEDLGH---------LKNGLGNILSSNNNGTGNGHSLSEKYAHEQAPLTGGYKLPPR 132
            ....|| ..:|..|         |...:.::....|..:.....||:             |:|
  Rat    71 PPKEEW-TDDDQEHIRVFPYQIRLSAAMSDVTGLQNANSETSSQLSD-------------KIP-- 119

  Fly   133 SSESEESDFDSDLNGGSSAESSSSCGLFGCRPRWARRFASTHVFMVVFLLAYILQGMYMTYFVSV 197
                  :|.|.....||....|            .:||.:.:.|::.|.:..:.||:........
  Rat   120 ------TDLDGPFGLGSLVVPS------------LQRFNNINFFLISFCILTLAQGIVFGLTDLS 166

  Fly   198 ITTIEKLFQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALPHF 262
            |...|:.|.:......:|.:|.::..:...:::.::.|||.|.||:|....|..:.:...|||:.
  Rat   167 IGNFERDFYLSHPEKILLTTAYDLSSLLVVIIVAHYGGRGRRSRWVATAAFLVGLGSIIGALPYL 231

  Fly   263 IFGEQLMHSSVILQQTQVSPPNNSFSSHWLNASSEQVNPNLCILGGNQTHSGSECNEERQLEQAS 327
            .:                                |.::|        ...:|..|.:|.|....:
  Rat   232 KY--------------------------------EVIHP--------VEETGELCKDEEQRTMPN 256

  Fly   328 HSKITVIVLCIFFGSLLS---SGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGF 389
            ..||......|.:.|::.   .|.....:..||:.||.||:.|..:.:|:.:.....:||...|:
  Rat   257 CEKIIPFKSEIIYLSVIGQCFQGFASMPMYVLGMTYIYDNISSYLAGIYLGIADASFVLGYGLGY 321

  Fly   390 IFGSFCTRWYVNFS-----NPGFDATDPRWIGAWWLGPVAIGSLMLLASIAMF---SFPKQLRGK 446
            ..||...|..:|.|     |..|    ..|...|:||   ..|..|||...:|   .||.:|.|.
  Rat   322 AVGSPNLRPSLNHSSEEKVNDNF----LWWQFNWFLG---FFSATLLAWFTVFPLLCFPHRLPGS 379

  Fly   447 QKPPGQTATPAAPVEPEEKP----KLKD------FPKTVRR---QLSNDILMFRTASCVFHLLPI 498
            .|         ..|..|.:|    |.||      |...:|.   .:.|.:||..:.......|.:
  Rat   380 NK---------LRVWKENEPFFYKKYKDLKYGYSFQDLLRALWYLVKNPLLMCYSMCKATESLAL 435

  Fly   499 AGLYTFLPKYLETQFRLATYDANMIAAFCGILVMG--IGIVISGLFILKRKPTARGVAAWIAFTA 561
            .|...|||||||.||.|:...|.::...  ||:.|  ||..:.|..:.|.|.:.:....:|..|:
  Rat   436 IGATEFLPKYLENQFLLSPSSAALLTGI--ILIPGGAIGNFLGGFIVSKMKMSCKTQMRFITVTS 498

  Fly   562 LVYSAGMIILMFIGCSMNDFAGYKPSDGNSPALIEPTCSAALNCTCDKENFAPICA-DGKMYISA 625
            ::.....::..|:.|....|||.......|..|...|.....:|.|....:..||. |...|.|.
  Rat   499 VISLLLFVLNAFVKCERVKFAGINSDYEGSGTLGNLTAPCNAHCGCTSHTYYAICGRDEIEYFSP 563

  Fly   626 CHAGCSSSSLRPSDNRTLYSDCACIP----------DAPEAVNGYCDNNCKNF-IYFILIFAICV 679
            |.|||.:|. ..:..:||| :|:||.          |..:|..|.|:..|... ::|...|:..|
  Rat   564 CFAGCLNSK-ELNYEKTLY-NCSCIKHGLANADSENDPIDAFLGKCNTKCYALPLFFAFFFSSIV 626

  Fly   680 FMHSTSEVGSMLLVMRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIWK-SVCGKH 743
            |..|.| :...|:::|.......::.:.|..:.:.:||::|.|:::.....|:|..|. :.||..
  Rat   627 FSSSAS-IPITLIILRTLPTSLHSLGLAVTYTILRIFGSIPGPLLFRIASSSSCSYWDINKCGLR 690

  Fly   744 GACSLYDADTFRQYFLGITAGIMFLAFLMDLVVWRKAHRIDIAPE 788
            |.|.:|:........:|:......::.|:.|:...|.:.:.:..|
  Rat   691 GHCWIYNKFKMMSILMGLCISCKLISTLLSLLALLKYNVLRVGSE 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_001163460.1	OATP	175..754	CDD:335235	149/617 (24%)
Slco6b1	NP_596903.1	OATP	144..701	CDD:281175	149/617 (24%)
		MFS	146..>510	CDD:119392	96/421 (23%)
		KAZAL_SLC21	534..587	CDD:238650	18/54 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810