Protein Alignment Oatp74D and Slco2b1

DIOPT Version :10

• Sequence 1: NP_648989.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: XP_006229783.1
• Gene: Slco2b1 / 140860
• RGDID: 621391
• Length: 693
• Species: Rattus norvegicus
• Alignment Length: 745
• Identity: 196/745 - (26%)
• Similarity: 333/745 - (44%)
• Gaps: 121/745 - (16%)

  Fly   126 GYKLPPRSSES--------------EESDFDSDLNGGSSAESSSSCGLFGCRPRWARRFASTHVF 176
            |.::|.||:::              |..|...|                 .:||  ..|.:...|
  Rat     8 GPQMPDRSTKATMGAEDIHERKVSMEPRDSHQD-----------------AQPR--GMFQNIKFF 53

  Fly   177 MVVFLLAYILQGMYMTYFVSVITTIEKLFQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHRPR 241
            ::...:..:.|.|...|..|.|:|:||.|.:.|:|:|:|.:.:|:|.|...:.::||..|.||||
  Rat    54 VLCHSILQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLAAFNEVGNISLILFVSYFGSRVHRPR 118

  Fly   242 WIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQVSPPNNSFSSHWLNASSEQVNPNLCI- 305
            .|.||.:|.::|....||||||        |...:....||.:.          |:....:||:
  Rat   119 MIGCGAILVAVAGLLMALPHFI--------SEPYRYDHSSPEDR----------SQDFEASLCLP 165

  Fly   306 --LGGNQTHSGSECNEERQLEQASHSKITVIVLCIFFGSLLSSGIGQTAVATLGIPYIDDNVGSK 368
              :......|...|:...:.:.     :|::.:.....:||  |||...:...||.||||.....
  Rat   166 TTMAPASALSNDSCSSRTETKH-----LTMVGIMFTAQTLL--GIGGVPIQPFGISYIDDFAHHS 223

  Fly   369 QSPMYMAVTIGMRILGPASGFIFGSFCTRWYVNFS---NPGFDAT--DPRWIGAWWLGPVAIGSL 428
            .||:|:.:...:.::||...:..||...|.||:..   ..|.:.|  ||||:||||||.:....|
  Rat   224 NSPLYLGILFAITMMGPGLAYGLGSLMLRLYVDIDRMPEGGINLTTKDPRWVGAWWLGFLISAGL 288

  Fly   429 MLLASIAMFSFPK-------QLRGKQKPPGQTATPAAPVE---------------PEEKPKL--- 468
            ::||:...|.||:       :|..:||.....|:..:..|               |:..|.|
  Rat   289 VVLAASPYFFFPREMPKEKYELHFRQKVLAGGASIGSKGEELSSQHEPLKKQAGLPQIAPDLTVV 353

  Fly   469 ---KDFPKTVRRQLSNDILMFRTASCVFHLLPIAGLYTFLPKYLETQFRLATYDANMIAAFCGIL 530
               |.||:.:.|.|.:.|.:....|.|.....:||..|||||:||.||.:....||::.....|.
  Rat   354 QFIKVFPRVLLRTLRHPIFLLVVLSQVCTSSMVAGTATFLPKFLERQFSITASFANLLLGCLTIP 418

  Fly   531 VMGIGIVISGLFILKRKPTARGVAAWIAFTALVYSAGMIILMFIGCSMNDFAGYKPSDGNSPA-L 594
            :..:|||:.|:.:.:...:....:|.....:|:.....:.|.|||||.:..||.....|..|. .
  Rat   419 LAIVGIVVGGVLVKRLHLSPMQCSALCLLGSLLCLLLSLPLFFIGCSTHHIAGITQDLGAQPGPS 483

  Fly   595 IEPTCSAALNCTCDKENFAPICADGKMYI---SACHAGCSSSSLRPS--DNRTLYSDCACIPDAP 654
            :.|.||..  |:|..::|.|:| |...|:   :.|||||:...::.:  .::..|::|:|:....
  Rat   484 LFPGCSEP--CSCQSDDFNPVC-DTSAYVEYTTPCHAGCTGRVVQEALDKSQVFYTNCSCVAGNG 545

  Fly   655 EAVNGYCDNNCKNFIY-FILIFAICVFMHSTSEVGSMLLVMRCTHPKDKAMAMGVIQSAIGLFGN 718
            ....|.|::.|...:. |||:.::...:.|.:...|.:|::|....:||.:|:|:....:.:...
  Rat   546 TISAGSCESACSRLVLPFILLISLGAAVASITHTPSFMLILRGVKKEDKTLAVGMQFMLLRVLAW 610

  Fly   719 VPCPIIYGAVVDSACLIWKSVCGKHGACSLYDADTFRQYFLGI----TAGIMFLAFLMDLVVWRK 779
            :|.|:|:|:.:|:.|:.|...||:...|..||.|..|..|:|:    .:|.: :.|.:.|.:.|
  Rat   611 MPSPVIHGSAIDTTCVHWALTCGRRAVCRYYDHDLLRNRFIGLQFFFKSGSL-VCFALVLAILR- 673

  Fly   780 AHRIDIAPEDPQEGGPASNGRTLEVSESKQ 809
                       |:...||...|::.|:.::
  Rat   674 -----------QQSREASTKATVKSSDLQE 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_648989.1	OATP	175..754	CDD:460821	174/621 (28%)
Slco2b1	XP_006229783.1	MFS	50..587	CDD:475125	156/564 (28%)