DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp74D and SLCO6A1

DIOPT Version :9

Sequence 1:	NP_001163460.1	Gene:	Oatp74D / 39954	FlyBaseID:	FBgn0036732	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001275931.1	Gene:	SLCO6A1 / 133482	HGNCID:	23613	Length:	719	Species:	Homo sapiens

Alignment Length:	700	Identity:	157/700 - (22%)
Similarity:	269/700 - (38%)	Gaps:	128/700 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 GGYKLPPRSSES---EESDFDSDLNGGSSAESSSSCGLFGCRPRWARRFAST--------HVFMV 178
            ||::...::..|   :..:.|..|        ...||| ||       ..||        ..||:
Human    62 GGFRKRKKAKSSVSKKPGEVDDSL--------EQPCGL-GC-------LVSTCCECCNNIRCFMI 110

  Fly   179 VFLLAYILQGMYMTYFVSVITTIEKLFQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHRPR-- 241
            .:.:..|.||:........|...:|.:|:|   |...|:..:...|.:.::..:.|..|.|.:
Human   111 FYCILLICQGVVFGLIDVSIGDFQKEYQLK---TIEKLALEKSYDISSGLVAIFIAFYGDRKKVI 172

  Fly   242 WIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQVSPPNNSFSSHWLNASSEQVNPNLCIL 306
            |......|..:.:..||.|.  ..|:...|.|                     ..|.:...:.::
Human   173 WFVASSFLIGLGSLLCAFPS--INEENKQSKV---------------------GIEDICEEIKVV 214

  Fly   307 GGNQTHSGSECNEERQLEQASHSKITVIVLCIFFGSLLSSGIGQTAVATLGIPYIDDNVGSKQSP 371
            .|.|: ||.....:              .|..|.......||....:..|||.:||:||.:..:.
Human   215 SGCQS-SGISFQSK--------------YLSFFILGQTVQGIAGMPLYILGITFIDENVATHSAG 264

  Fly   372 MYMAVTIGMRILGPASGFIFGSFCTRWYVN---FSNPGFDATDPRWIGAWWLGPVAIGSLMLLAS 433
            :|:.:.....::|.|.|::.|:...:...|   .:|...:...|.|:..||:..:....:.....
Human   265 IYLGIAECTSMIGYALGYVLGAPLVKVPENTTSATNTTVNNGSPEWLWTWWINFLFAAVVAWCTL 329

  Fly   434 IAMFSFPKQLRGKQKPPGQTATPAAPVEPEEKPK-----------------LKDFPKTVRRQLSN 481
            |.:..||..:      ||.|...|      .|.|                 :||....:...:.|
Human   330 IPLSCFPNNM------PGSTRIKA------RKRKQLHFFDSRLKDLKLGTNIKDLCAALWILMKN 382

  Fly   482 DILMFRTASCVFHLLPIAGLYTFLPKYLETQFRLATYDANMIAAFCGILVMG--IGIVISGLFIL 544
            .:|:....|.....|.|.|...|||.|||.||.|....|..:|..  :|:.|  :|.::.|:.:.
Human   383 PVLICLALSKATEYLVIIGASEFLPIYLENQFILTPTVATTLAGL--VLIPGGALGQLLGGVIVS 445

  Fly   545 KRKPTARGVAAWIAFTALVYSAGMIILMFIGCSMNDFAGYKPSDGNSPALIEPTCSAALNCTCDK 609
            ..:.:.:.:..:|..|:::....::.::|:.|:...|||.......:..|...|......|.|..
Human   446 TLEMSCKALMRFIMVTSVISLILLVFIIFVRCNPVQFAGINEDYDGTGKLGNLTAPCNEKCRCSS 510

  Fly   610 ENFAPICA-DGKMYISACHAGCSSSSLRPSDNRTLYSDCACIP----------DAPEAVNGYCDN 663
            ..::.||. |...|.|.|.|||:.|  :..:.:.:|.:|:||.          |..:|..|.||.
Human   511 SIYSSICGRDDIEYFSPCFAGCTYS--KAQNQKKMYYNCSCIKEGLITADAEGDFIDARPGKCDA 573

  Fly   664 NCKNFIYFI-LIFAICVFMHSTSEVGSMLLVMRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYGA 727
            .|.....|| .||:..:| ...|.|..:|.:.|....|.:::|:||....:.:||.:|.|.|:..
Human   574 KCYKLPLFIAFIFSTLIF-SGFSGVPIVLAMTRVVPDKLRSLALGVSYVILRIFGTIPGPSIFKM 637

  Fly   728 VVDSACLIWKSV--CGKHGACSLYDADTFRQYFLGITAGIMFLAFLMDLV 775
            ..:::|:: :.|  ||..|.|.:|:..  :..||  ..||.||..|..::
Human   638 SGETSCIL-RDVNKCGHTGRCWIYNKT--KMAFL--LVGICFLCKLCTII 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_001163460.1	OATP	175..754	CDD:335235	138/616 (22%)
SLCO6A1	NP_001275931.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46
		OATP	107..665	CDD:281175	138/618 (22%)
		MFS	109..>330	CDD:119392	49/261 (19%)
		KAZAL_SLC21	498..551	CDD:238650	16/54 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810