DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp74D and Slco3a1

DIOPT Version :9

Sequence 1:	NP_001163460.1	Gene:	Oatp74D / 39954	FlyBaseID:	FBgn0036732	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_076397.2	Gene:	Slco3a1 / 108116	MGIID:	1351867	Length:	710	Species:	Mus musculus

Alignment Length:	741	Identity:	218/741 - (29%)
Similarity:	341/741 - (46%)	Gaps:	107/741 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 KLPPRSSESEESDFDSDLNGGSSAESSSSCGLFGCRPRWARRFASTHVFMVVFLLAYILQGMYMT 192
            |.|..||....|   .:|.|..:..:........|       |::..:|:|......:.||....
Mouse     4 KKPGGSSGGGRS---GELQGDEAQRNKKKKKKVSC-------FSNIKIFLVSECALMLAQGTVGA 58

  Fly   193 YFVSVITTIEKLFQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSC 257
            |.|||:||:|:.|.::|...|::.|:.|:|.:...:.::||..||||||.|.||.::.::.|...
Mouse    59 YLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGALLS 123

  Fly   258 ALPHFIFGEQLMHSSVILQQTQVSPPNNSFSSHW---------LNASSEQVNPNLCILGGNQTHS 313
            |||.|:..:....:..|               .|         .|.||....|:..::..|:|
Mouse   124 ALPEFLTHQYKYEAGEI---------------RWGAEGRDVCATNGSSSDEGPDPDLICRNRT-- 171

  Fly   314 GSECNEERQLEQASHSKITVIVLCIFFGSLLSSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTI 378
                             .|.::..:..|:.:..|||.|.|..||:.||||:|..|.|.:|:.:..
Mouse   172 -----------------ATNMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILF 219

  Fly   379 GMRILGPASGFIFGSFCTRWYV-----NFSNPGFDATDPRWIGAWWLGPVAIGSLMLLASIAMFS 438
            .|.:.|||.|||.|||||:.||     :.||......|||||||||.|.:..|:|:..:|:.||.
Mouse   220 TMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMFG 284

  Fly   439 FPKQL-----------------RGKQKPPGQTATPAAPVEPEEK----PKLKDFPKTVRRQLSND 482
            ||:.|                 |..::|.........|:||:..    .:|:..||..:..|||.
Mouse   285 FPQSLPPHSDPGMESEQAMLPEREYERPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNP 349

  Fly   483 ILMFRTASCVFHLLPIAGLYTFLPKYLETQFRLATYDANMIAAFCGILVMGIGIVISGLFILKRK 547
            :......:....:..:||...||.||||.||.|.|..||.:.....|....:||.:.||.:.|..
Mouse   350 VFTCIVLAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLS 414

  Fly   548 PTARGVAAWIAFTALVYSAGMIILMFIGCSMNDFAGYKPSDGNSPA---LIEPTCSAALNCTCDK 609
            .:|.|.........||.:|..:..:|:||.....||.....||:.|   .::|......||.|..
Mouse   415 LSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVRYGNNSARGSALDPYSPCNNNCECQT 479

  Fly   610 ENFAPIC-ADGKMYISACHAGCSSSSLRPSDNRTLYSDCACI----PDAPEAVNGYCDN-NCKN- 667
            ::|.|:| |||..|:|||.|||:|::|         :.|||:    |:....|.|.|.: .|:.
Mouse   480 DSFTPVCGADGITYLSACFAGCNSTNL---------TGCACLTTVPPENASVVPGKCPSPGCQEA 535

  Fly   668 FIYFILIFAICVFMHSTSEVGSMLLVMRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSA 732
            |:.|:.:..:|..:.:.::..|:::::|...|:.|:.|:||:...:.|.|.:|.|:|:||.:||.
Mouse   536 FLTFLCVMCVCSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDST 600

  Fly   733 CLIWKSVCGKHGACSLYDADTFRQYFLGITAGIMFLAFLMDLVVW---RKAHRIDIAPEDPQEGG 794
            ||.|.:.||:.|||.|||...:|..::.|...:...||::....|   ||.::..|   ...|||
Mouse   601 CLFWSTFCGEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNYKRYI---KNHEGG 662

  Fly   795 PASN---GRTLEVSESKQPITPAPDT 817
            .:::   ..||.:....:...||..|
Mouse   663 LSTSEFFASTLTLDNLGRDPVPAHQT 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_001163460.1	OATP	175..754	CDD:335235	193/623 (31%)
Slco3a1	NP_076397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		7/23 (30%)
Slco3a1	NP_076397.2	MFS_SLCO3_OATP3	39..563	CDD:340960	167/566 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835526
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750