Protein Alignment Oatp74D and Slco4a1

DIOPT Version :10

• Sequence 1: NP_648989.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_683735.1
• Gene: Slco4a1 / 108115
• MGIID: 1351866
• Length: 723
• Species: Mus musculus
• Alignment Length: 799
• Identity: 213/799 - (26%)
• Similarity: 356/799 - (44%)
• Gaps: 142/799 - (17%)

  Fly    49 LLSQHNNGTTNGEVTTPPPSTVLYESTPSNNNEWKAPEDLGHLKNGLGNILSSNNNGTGNGHSLS 113
            |.:..::.|.:| ..|||.|    .::|::            |::..|.:.||:       ..|.
Mouse    18 LFTSTSSATDSG-CDTPPSS----RASPAS------------LRSAHGTLGSSS-------QPLF 58

  Fly   114 EKYAHEQAPLTGGYKLPPRSSESEESDFDSDLNGGSSAESSSSCGLFGCRPRWARRFASTHVFMV 178
            |..|.:            |||::..     ::...||...:|.||.....|:..:.|.:...|:.
Mouse    59 EPQAEK------------RSSQTAR-----EVQYVSSGPQNSLCGWQAFTPKCLQVFNTPKGFLF 106

  Fly   179 VFLLAYILQGMYMTYFV-SVITTIEKLFQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHRPRW 242
            ....|..||||.:..|: :|||:||:.|.:.|..:|::.|:.::........::||.|.||:|||
Mouse   107 FLCAASFLQGMTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRW 171

  Fly   243 IACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQVSPPNNSFSSHWLNASSEQVNPNLCILG 307
            :..|:::..|.:...|||||..|...:.                        ..|.:....|:.
Mouse   172 LGWGVLVLGIGSLVFALPHFTAGRYEVE------------------------MDEGLGTGTCLT- 211

  Fly   308 GNQTHSGSECNEERQLEQASHSKITVIVLCIFFGSLLSSGIGQTAVATLGIPYIDDNVGSKQSPM 372
             ||:|  .||.:       |.|.::...|....|.|| .|:|.|.:.|||:.|:|:||.|..||:
Mouse   212 -NQSH--VECKD-------SASGLSNYRLIFMLGQLL-HGVGATPLYTLGVTYLDENVKSSYSPI 265

  Fly   373 YMAVTIGMRILGPASGFIFGSFCTRWYVNFSNPGFDATD-PRWIGAWWLGPVAIGSLMLLASIAM 436
            |:|:.....|||||:|::.|......|..........|| |.|:||||:|.:..|....|.:|.:
Mouse   266 YIAIFYTAAILGPAAGYLIGGAMLNVYTEVGQRTELTTDSPLWVGAWWIGFLGTGIAAFLIAIPI 330

  Fly   437 FSFPKQLRGKQKPPGQTATPAAPVEPEEKPKLKD----------FPKTVRRQLSNDILMFRTASC 491
            ..:|:||.|.|:        ...:...|..:|||          |.||||....:..|:.|..:.
Mouse   331 LGYPRQLPGSQR--------YVVMRAAETQQLKDHSRGAVSNPAFGKTVRDLPLSIWLLLRNPTF 387

  Fly   492 VFHLLP-------IAGLYTFLPKYLETQFRLATYDANMIAAFCGILVM---GIGIVISGLFILKR 546
            :...|.       |||:.||.||:.|.||.|:..:|   |...|.||:   |.|.::.|..:.|.
Mouse   388 ILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEA---ATLFGYLVVPAGGGGTLLGGFLVNKF 449

  Fly   547 KPTARGVAAWIAFTALVYSAGMIILMFIGCSMNDFAGYKPSDGNSPAL-------IEPTCSAALN 604
            |....|:..:..|..|.......:.: :.|.....||.  :.|...:|       ::..|: |:.
Mouse   450 KLRGSGIIRFCLFCTLTSLLAFFVFL-MHCPNVHMAGV--TTGYVGSLLPKGQLDLKAACN-AIY 510

  Fly   605 CTCDKENFAPIC-ADGKMYISACHAGCSSSSLRPSDNRTLYSDCACIPDAP-----EAVNGYCDN 663
            | |..::::|:| :||.||.|.|:|||.:.:......:.:|..|:||.:..     .|..|.|.:
Mouse   511 C-CQPKHYSPLCGSDGTMYYSPCYAGCPADAETDLGGQKVYRGCSCILEKASSGWGNATAGKCAS 574

  Fly   664 NC--KNFIYFILIFAICVFMHSTSEVGSMLLVMRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYG 726
            .|  |.|: .:|:|.:.:|.. .|.:.::...:||...:.::.|:|:....:...|::|.||.:|
Mouse   575 TCQSKPFL-LVLVFVVIIFTF-LSSIPALTATLRCVSDRQRSFALGIQWIVVRTLGSIPGPIAFG 637

  Fly   727 AVVDSACLIWKSVCGKHGACSLYDADTFRQYFL--GITAGIM-FLAFLMDLVVWRKAHRIDIAPE 788
            .|:|.|||:|:..||..|:|.:|:.:...:|.|  |:|..:: ||.|:....:::       :|.
Mouse   638 WVIDKACLLWQDQCGHQGSCFVYENEAMSRYMLIAGLTFKVLGFLFFVAAYFLYK-------SPS 695

  Fly   789 DPQEGGPASNGRTLEVSES 807
            ...:|..||.......|:|
Mouse   696 VSSDGLEASLPSQSSASDS 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_648989.1	OATP	175..754	CDD:460821	175/615 (28%)
Slco4a1	NP_683735.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	23..64		14/64 (22%)
		MFS	101..606	CDD:475125	155/558 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	700..723		5/15 (33%)