DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp74D and Slco4a1

DIOPT Version :9

Sequence 1:	NP_001163460.1	Gene:	Oatp74D / 39954	FlyBaseID:	FBgn0036732	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001342147.1	Gene:	Slco4a1 / 108115	MGIID:	1351866	Length:	723	Species:	Mus musculus

Alignment Length:	799	Identity:	213/799 - (26%)
Similarity:	356/799 - (44%)	Gaps:	142/799 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 LLSQHNNGTTNGEVTTPPPSTVLYESTPSNNNEWKAPEDLGHLKNGLGNILSSNNNGTGNGHSLS 113
            |.:..::.|.:| ..|||.|    .::|::            |::..|.:.||:       ..|.
Mouse    18 LFTSTSSATDSG-CDTPPSS----RASPAS------------LRSAHGTLGSSS-------QPLF 58

  Fly   114 EKYAHEQAPLTGGYKLPPRSSESEESDFDSDLNGGSSAESSSSCGLFGCRPRWARRFASTHVFMV 178
            |..|.:            |||::..     ::...||...:|.||.....|:..:.|.:...|:.
Mouse    59 EPQAEK------------RSSQTAR-----EVQYVSSGPQNSLCGWQAFTPKCLQVFNTPKGFLF 106

  Fly   179 VFLLAYILQGMYMTYFV-SVITTIEKLFQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHRPRW 242
            ....|..||||.:..|: :|||:||:.|.:.|..:|::.|:.::........::||.|.||:|||
Mouse   107 FLCAASFLQGMTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRW 171

  Fly   243 IACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQVSPPNNSFSSHWLNASSEQVNPNLCILG 307
            :..|:::..|.:...|||||..|...:.                        ..|.:....|:.
Mouse   172 LGWGVLVLGIGSLVFALPHFTAGRYEVE------------------------MDEGLGTGTCLT- 211

  Fly   308 GNQTHSGSECNEERQLEQASHSKITVIVLCIFFGSLLSSGIGQTAVATLGIPYIDDNVGSKQSPM 372
             ||:|  .||.:       |.|.::...|....|.|| .|:|.|.:.|||:.|:|:||.|..||:
Mouse   212 -NQSH--VECKD-------SASGLSNYRLIFMLGQLL-HGVGATPLYTLGVTYLDENVKSSYSPI 265

  Fly   373 YMAVTIGMRILGPASGFIFGSFCTRWYVNFSNPGFDATD-PRWIGAWWLGPVAIGSLMLLASIAM 436
            |:|:.....|||||:|::.|......|..........|| |.|:||||:|.:..|....|.:|.:
Mouse   266 YIAIFYTAAILGPAAGYLIGGAMLNVYTEVGQRTELTTDSPLWVGAWWIGFLGTGIAAFLIAIPI 330

  Fly   437 FSFPKQLRGKQKPPGQTATPAAPVEPEEKPKLKD----------FPKTVRRQLSNDILMFRTASC 491
            ..:|:||.|.|:        ...:...|..:|||          |.||||....:..|:.|..:.
Mouse   331 LGYPRQLPGSQR--------YVVMRAAETQQLKDHSRGAVSNPAFGKTVRDLPLSIWLLLRNPTF 387

  Fly   492 VFHLLP-------IAGLYTFLPKYLETQFRLATYDANMIAAFCGILVM---GIGIVISGLFILKR 546
            :...|.       |||:.||.||:.|.||.|:..:|   |...|.||:   |.|.::.|..:.|.
Mouse   388 ILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEA---ATLFGYLVVPAGGGGTLLGGFLVNKF 449

  Fly   547 KPTARGVAAWIAFTALVYSAGMIILMFIGCSMNDFAGYKPSDGNSPAL-------IEPTCSAALN 604
            |....|:..:..|..|.......:.: :.|.....||.  :.|...:|       ::..|: |:.
Mouse   450 KLRGSGIIRFCLFCTLTSLLAFFVFL-MHCPNVHMAGV--TTGYVGSLLPKGQLDLKAACN-AIY 510

  Fly   605 CTCDKENFAPIC-ADGKMYISACHAGCSSSSLRPSDNRTLYSDCACIPDAP-----EAVNGYCDN 663
            | |..::::|:| :||.||.|.|:|||.:.:......:.:|..|:||.:..     .|..|.|.:
Mouse   511 C-CQPKHYSPLCGSDGTMYYSPCYAGCPADAETDLGGQKVYRGCSCILEKASSGWGNATAGKCAS 574

  Fly   664 NC--KNFIYFILIFAICVFMHSTSEVGSMLLVMRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYG 726
            .|  |.|: .:|:|.:.:|.. .|.:.::...:||...:.::.|:|:....:...|::|.||.:|
Mouse   575 TCQSKPFL-LVLVFVVIIFTF-LSSIPALTATLRCVSDRQRSFALGIQWIVVRTLGSIPGPIAFG 637

  Fly   727 AVVDSACLIWKSVCGKHGACSLYDADTFRQYFL--GITAGIM-FLAFLMDLVVWRKAHRIDIAPE 788
            .|:|.|||:|:..||..|:|.:|:.:...:|.|  |:|..:: ||.|:....:::       :|.
Mouse   638 WVIDKACLLWQDQCGHQGSCFVYENEAMSRYMLIAGLTFKVLGFLFFVAAYFLYK-------SPS 695

  Fly   789 DPQEGGPASNGRTLEVSES 807
            ...:|..||.......|:|
Mouse   696 VSSDGLEASLPSQSSASDS 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_001163460.1	OATP	175..754	CDD:335235	175/615 (28%)
Slco4a1	NP_001342147.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..64		14/64 (22%)
		OATP	103..665	CDD:308646	175/615 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	700..723		5/15 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810