Protein Alignment Oatp74D and Slco1a5

DIOPT Version :10

• Sequence 1: NP_648989.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_570931.1
• Gene: Slco1a5 / 108096
• MGIID: 1351865
• Length: 670
• Species: Mus musculus
• Alignment Length: 653
• Identity: 192/653 - (29%)
• Similarity: 325/653 - (49%)
• Gaps: 82/653 - (12%)

  Fly   168 RRFASTHVFMVVFLLAYI---LQGMYMTYFVSVITTIEKLFQIKSKTTGILLSASEMGQICTAML 229
            |.|:...:|::....||:   |.|:||.   |::|.||:.|.|.:...|::..:.|:|.:...:|
Mouse    14 RCFSKIKMFLLALTCAYVSKSLSGIYMN---SMLTQIERQFDIPTSIVGLINGSFEIGNLLLIIL 75

  Fly   230 LTYFAGRGHRPRWIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQVSPPNNSFSSHWLNA 294
            ::||..:.|||..|..|.|:..:..|..:||||:.|.       ...:|.:||.:|..|
Mouse    76 VSYFGTKLHRPIMIGIGCVIMGLGCFLMSLPHFLMGR-------YEYETTISPTSNLSS------ 127

  Fly   295 SSEQVNPNLCILGGNQ----THSGSECNEERQLEQASHSKITVIVLCIFFGSLLSSGIGQTAVAT 355
                 |..||:....|    |...:||.:|.:         :::.:.:..|::: .|||:|.:..
Mouse   128 -----NSFLCMENRTQTLKPTQDPAECVKEMK---------SLMWIYVLVGNII-RGIGETPIMP 177

  Fly   356 LGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRWYVNFSNPGFD-----ATDPRWI 415
            |||.||:|...|:.||:|:.:....:::||..|.:.||||.|.||:..:...|     .||.||:
Mouse   178 LGISYIEDFAKSENSPLYIGILESGKMIGPIVGLLLGSFCARIYVDTGSVNTDDLTITPTDTRWV 242

  Fly   416 GAWWLGPVAIGSLMLLASIAMFSFPKQL--RGKQKPPGQTATPAAPVEPEEKPKLKDFPKTVRRQ 478
            ||||:|.:....:.:|.||..|.|||.|  .|.|....:|       |.:::.|.::..|...|.
Mouse   243 GAWWIGFLVCAGVNILTSIPFFFFPKTLPKEGLQDNVDRT-------ENDKEEKHREKAKEENRG 300

  Fly   479 LSNDILMF-RTASC--VFHLLPIA---------GLYTFLPKYLETQFRLATYDANMIAAFCGILV 531
            ::.|.|.| ::.||  ::.||.:.         .::||||||||.|:..:|.:..::...|.:..
Mouse   301 ITKDFLPFMKSLSCNPIYMLLILTSVLQINAFINMFTFLPKYLEQQYGKSTSEVVLLIGVCNLPP 365

  Fly   532 MGIGIVISGLFILKRKPTARGVAAWIAFTALVYSAGMIILMF-IGCSMNDFAGYKPS-DG-NSPA 593
            :.||.::.| ||:|:.......||::||...::...:....| |.|.....||...| :| ..|.
Mouse   366 ICIGYLLIG-FIMKKFRITVKKAAYMAFCLSLFEYLLSYFHFMISCDNFQVAGLTTSYEGVQHPL 429

  Fly   594 LIEPTCSAALN--CTCDKENFAPICAD-GKMYISACHAGCSSSSLRPSDNRTLYSDCACIPDA-- 653
            .:|....|..|  |:|....:.|:|.| |..|:|||.|||..|.  ......::.:|:||..:
Mouse   430 YVENKVLADCNTRCSCLTNTWDPVCGDNGLSYMSACLAGCEKSV--GMGTHMVFQNCSCIQSSGN 492

  Fly   654 PEAVNGYCDN--NCKNFI-YFILIFAICVFMHSTSEVGSMLLVMRCTHPKDKAMAMGVIQSAIGL 715
            ..||.|.|..  .|.|.: ||:::..|..|::|.:.:...::::||...::|::.:|:......:
Mouse   493 SSAVLGLCKKGPECANKLQYFLIMSVIGSFIYSITAIPGYMVLLRCIKSEEKSLGIGLHAFCTRI 557

  Fly   716 FGNVPCPIIYGAVVDSACLIWKSV-CGKHGACSLYDADTFRQYFLGITA---GIMFLAFLMDLVV 776
            |..:|.||.:||::|..||.|.:: ||:.|||.:|:.:.||:.:|.:.|   |..:|.....|::
Mouse   558 FAGIPAPIYFGALIDRTCLHWGTLKCGEPGACRMYNINNFRRIYLVLPAALRGSSYLPAFFILIL 622

  Fly   777 WRK 779
            .||
Mouse   623 MRK 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_648989.1	OATP	175..754	CDD:460821	181/616 (29%)
Slco1a5	NP_570931.1	oat	1..625	CDD:273279	190/651 (29%)