DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp74D and SLCO1B1

DIOPT Version :9

Sequence 1:	NP_001163460.1	Gene:	Oatp74D / 39954	FlyBaseID:	FBgn0036732	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_006437.3	Gene:	SLCO1B1 / 10599	HGNCID:	10959	Length:	691	Species:	Homo sapiens

Alignment Length:	715	Identity:	183/715 - (25%)
Similarity:	326/715 - (45%)	Gaps:	74/715 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 DFDSDLNGGSSAESSSSCGLFGCRPRWARRFASTHVFMVVFLLAYILQGMYMTYFVSVITTIEKL 204
            |.:..||..:.|:.|.:        :..|......:|:....|::|.:.:......|.|..||:.
Human     2 DQNQHLNKTAEAQPSEN--------KKTRYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIHIERR 58

  Fly   205 FQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALPHFIFGEQLM 269
            |:|.|...|.:..:.|:|.:...:.::||..:.|||:.|..|..:..|.....|||||..| ...
Human    59 FEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMG-YYR 122

  Fly   270 HSSVILQQTQVSPPNNSFSSHWLNASSEQVNPNLCILGGNQTHSGSECNEERQLEQASHSKITVI 334
            :|    ::|.::...||.|:    .|:..:|..|.:...:....|..|.:|      |.|.:.:.
Human   123 YS----KETNINSSENSTST----LSTCLINQILSLNRASPEIVGKGCLKE------SGSYMWIY 173

  Fly   335 VLCIFFGSLLSSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRW- 398
            |   |.|::| .|||:|.:..||:.||||......|.:|:.:...:.::||..||..||..::.
Human   174 V---FMGNML-RGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMY 234

  Fly   399 ----YVNFSNPGFDATDPRWIGAWWLGPVAIGSLMLLASIAMFSFPKQLRGKQKPPGQTATPAAP 459
                ||:.|......||.||:|||||..:..|...:::||..|..|:.....||.  :.|:.:..
Human   235 VDIGYVDLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQTPNKPQKE--RKASLSLH 297

  Fly   460 V-----EPEEKPKLKDFPKTVRRQLSNDILMFRT-----ASCVFHLLPI------AGLYTFLPKY 508
            |     |.::...|.:..|.:.:.::.....|::     ...:|.||.:      .|.:|::.||
Human   298 VLETNDEKDQTANLTNQGKNITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKY 362

  Fly   509 LETQFRLATYDANMIAAFCGILVMGIGIVISGLFILKRKPTARGVAAWIAFTALVYSAGMIILMF 573
            :|.|:...:..||::.....|.:...|:.:.|..|.|.|....|:|.:..|||::..:..::..|
Human   363 VEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYFF 427

  Fly   574 IGCSMNDFAGYKPS-DGNSPALIE---PTCSAALNCTCDKENFAPICA-DGKMYISACHAGCSSS 633
            |.|.....||...: |||:|....   |......:|.||:..:.|:|. :|..|||.|.|||.||
Human   428 ILCENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSS 492

  Fly   634 SLRPSDNRTLYSDCACIPDAP------EAVNGYC--DNNC-KNFIYFILIFAICVFMHSTSEVGS 689
            |  .:....::.:|:|:....      .|..|.|  |:.| :.|.:|:.|..:.:|..:......
Human   493 S--GNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAIQVLNLFFSALGGTSH 555

  Fly   690 MLLVMRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIWK-SVCGKHGACSLYDADT 753
            ::|:::...|:.|::|:|.....|...|.:..||.:||::|:.|:.|. :.||..|:|..|::.:
Human   556 VMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTNNCGTRGSCRTYNSTS 620

  Fly   754 FRQYFLGITAGI----MFLAFLMDLVVWRKAHRIDIAPEDPQEGGPASNGRTLEVSESKQPITPA 814
            |.:.:||:::.:    :.|..::...:.:|....||   :..|.|...:...||.....:...|:
Human   621 FSRVYLGLSSMLRVSSLVLYIILIYAMKKKYQEKDI---NASENGSVMDEANLESLNKNKHFVPS 682

Fly 815 814
Human 683 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_001163460.1	OATP	175..754	CDD:335235	165/614 (27%)
SLCO1B1	NP_006437.3	OATP	29..621	CDD:281175	165/614 (27%)
		MFS	31..>427	CDD:119392	108/416 (26%)
		KAZAL_SLC21	455..508	CDD:238650	19/54 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820