Protein Alignment Oatp74D and Slco2b1

DIOPT Version :10

• Sequence 1: NP_648989.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: XP_011239939.1
• Gene: Slco2b1 / 101488
• MGIID: 1351872
• Length: 697
• Species: Mus musculus
• Alignment Length: 747
• Identity: 196/747 - (26%)
• Similarity: 330/747 - (44%)
• Gaps: 125/747 - (16%)

  Fly   126 GYKLPPRSSES--------------EESDFDSDLNGGSSAESSSSCGLFGCRPRWARRFASTHVF 176
            |.::|.||:::              |..|...|                 .:||  ..|.:...|
Mouse    12 GPRMPDRSTKTTMGTEDMHERKVSVEPQDSHQD-----------------AQPR--GMFHNIKFF 57

  Fly   177 MVVFLLAYILQGMYMTYFVSVITTIEKLFQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHRPR 241
            ::...|..:.|.|...|..|.|:|:||.|.:.|:.:|:|.:.:|:|.:...:.::||..|.||||
Mouse    58 VLCHSLLQLTQLMISGYLKSSISTVEKRFGLSSQISGLLAAFNEVGNVSLILFVSYFGSRVHRPR 122

  Fly   242 WIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQVSPPNNSFSSHWLNASSEQVNPNLCI- 305
            .|..|.:|.:.|....||||||        |...:....|..|.|.          ....:||:
Mouse   123 MIGYGALLVATAGLLMALPHFI--------SEPYRYDHSSSDNRSL----------DFEASLCLP 169

  Fly   306 --LGGNQTHSGSECNEERQLEQASHSKITVIVLC-IFFGSLLSSGIGQTAVATLGIPYIDDNVGS 367
              :......|...|        :||::...:.:. |.|.:....|||...:...||.||||....
Mouse   170 TTMAPASALSNGSC--------SSHTETKHLTMVGIMFAAQTLLGIGGVPIQPFGISYIDDFAHH 226

  Fly   368 KQSPMYMAVTIGMRILGPASGFIFGSFCTRWYVNFS---NPGFDAT--DPRWIGAWWLGPVAIGS 427
            ..||:|:.:..|:..:||...:..||...|.||:..   ..|.:.|  ||||:||||||.:....
Mouse   227 SNSPLYIGILFGITTMGPGLAYGLGSLMLRLYVDIDRMPEGGINLTPKDPRWVGAWWLGFLISSG 291

  Fly   428 LMLLASIAMFSFPKQLRGKQK-----------PPGQTATPAAPVEPEEKPK-------------- 467
            |::|||...|.||::: .|:|           ....||:....:..:.:|.
Mouse   292 LVVLASSPYFFFPREM-PKEKHEFHFRRKVLASAASTASKGEDLSSQHEPLKKQAGLAQIAPDLT 355

  Fly   468 ----LKDFPKTVRRQLSNDILMFRTASCVFHLLPIAGLYTFLPKYLETQFRLATYDANMIAAFCG 528
                :|.||:.:.|.|.:.|.:....|.|.....:||:.|||||:||.||.:....|||:.....
Mouse   356 LVQFVKVFPRVLLRNLRHPIFLLVVLSQVCTSSMVAGMATFLPKFLERQFSITASFANMLLGCLT 420

  Fly   529 ILVMGIGIVISGLFILKRKPTARGVAAWIAFTALVYSAGMIILMFIGCSMNDFAGYKPSDGNSPA 593
            |.::.:||::.|:.:.:...:....:|.....:|:.....:.|.|||||.:..||.....|..|.
Mouse   421 IPLVIVGIMMGGVLVKRLHLSPVQCSALCLLGSLLCLLFSVPLFFIGCSTHQIAGITQDLGAQPG 485

  Fly   594 -LIEPTCSAALNCTCDKENFAPICADGKMYI---SACHAGCSSSSLRPS--DNRTLYSDCACIPD 652
             .:.|.||..  |:|..::|.|:| |...|:   :.|||||:...::.:  .::..|::|:|:..
Mouse   486 PSLFPGCSEP--CSCQSDDFNPVC-DTSAYVEYTTPCHAGCTGRVVQEALGKSQVFYTNCSCVAG 547

  Fly   653 APEAVNGYCDNNCKNFIY-FILIFAICVFMHSTSEVGSMLLVMRCTHPKDKAMAMGVIQSAIGLF 716
            ......|.|::.|...:. ||::|::...:.|.:...|.:|::|....:||.:|:|:....:.:.
Mouse   548 NGTVPAGSCESACSRLVLPFIVLFSLGAGLASITHTPSFMLILRGVKKEDKTLAVGMQFMLLRVL 612

  Fly   717 GNVPCPIIYGAVVDSACLIWKSVCGKHGACSLYDADTFRQYFLGI----TAGIMFLAFLMDLVVW 777
            ..:|.|:|:|:.:|:.|:.|...||:...|..||.|..|..|:|:    .:|.: :.|.:.|.:.
Mouse   613 AWMPSPVIHGSAIDTTCVHWALTCGRRAVCRYYDHDLLRNRFIGLQFFFKSGSL-VCFTLVLAIL 676

  Fly   778 RKAHRIDIAPEDPQEGGPASNGRTLEVSESKQ 809
            |            |:...||...|::.||.:|
Mouse   677 R------------QQSREASTRTTVKSSELQQ 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_648989.1	OATP	175..754	CDD:460821	172/623 (28%)
Slco2b1	XP_011239939.1	MFS	54..591	CDD:475125	154/566 (27%)