Protein Alignment Oatp74D and slco3a1

DIOPT Version :10

• Sequence 1: NP_648989.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: XP_002933360.2
• Gene: slco3a1 / 100498508
• XenbaseID: XB-GENE-6035424
• Length: 707
• Species: Xenopus tropicalis
• Alignment Length: 702
• Identity: 212/702 - (30%)
• Similarity: 328/702 - (46%)
• Gaps: 88/702 - (12%)

  Fly   132 RSSESEESDFDSDLNGGSSAESSSSCGLFGCRPRWARRFASTHVFMVVFLLAYILQGMYMTYFVS 196
            |||.....|...|.......:..:||            |.:..:|:|......:.||....|.||
 Frog     7 RSSSGRSGDPQGDEAQRKKKKKKTSC------------FLNIKIFLVSECALMLAQGTVGAYLVS 59

  Fly   197 VITTIEKLFQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALPH 261
            ::||:|:.|.::|...|::.|:.|:|.:...:.::||..||||||.|.||.::.::.|...|||.
 Frog    60 MLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGALLSALPE 124

  Fly   262 FIFGEQLMHSSVILQQTQVSPPNNSFSSHWLNASSEQVNPNLCILGGNQTHSGSECNEERQLEQA 326
            |     |.|      |.:..|....:.:.         ..::|.:  |.|.|| |..:...:  .
 Frog   125 F-----LTH------QYKYEPGEIRWGAE---------GRDICSI--NDTSSG-EIPDPDII--C 164

  Fly   327 SHSKITVIVLCIFFGSLLSSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIF 391
            |::..|.::..:..|:.:..|||.|.|..||:.||||:|..|.|.:|:.:...|.:.|||.|||.
 Frog   165 SNTATTNMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFIL 229

  Fly   392 GSFCTRWYVN---FSNPGFDAT--DPRWIGAWWLGPVAIGSLMLLASIAMFSFPKQLRGKQKPPG 451
            |||||:.||:   ......|.|  |||||||||.|.:..|.|:..:|:.||.||:.|..:.....
 Frog   230 GSFCTKIYVDAFLTDTSKLDITPDDPRWIGAWWAGFLLCGVLLFFSSLLMFGFPQSLSPRIDRSE 294

  Fly   452 QTATPAAPVEPEEKPK---------------------LKDFPKTVRRQLSNDILMFRTASCVFHL 495
            ::.....|....|:||                     |:..||..:..|||.:......:....:
 Frog   295 ESEQTMLPDTEYERPKPSNGVLRHSSETEDGTSCFQQLRVIPKVTKHLLSNPVFTCIVLAACMEI 359

  Fly   496 LPIAGLYTFLPKYLETQFRLATYDANMIAAFCGILVMGIGIVISGLFILKRKPTARGVAAWIAFT 560
            ..:||...||.||||.||.|.|..||.:.....|....:||.:.||.:.|...:|.|........
 Frog   360 AVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLV 424

  Fly   561 ALVYSAGMIILMFIGCSMNDFAGYKPSDGN---SPALIEPTCSAALNCTCDKENFAPIC-ADGKM 621
            .||.:|..:..:|:||.....||.....||   ..|.:|...|...:|.|..::|.|:| |||..
 Frog   425 NLVSTACYVSFLFLGCDTGPVAGVTVPYGNISVPGASVERYASCNTDCECQTDSFTPVCGADGIT 489

  Fly   622 YISACHAGCSSSSLRPSDNRTLYSDCACIPDAP----EAVNGYCDN-NCKN-FIYFILIFAICVF 680
            |:|||.|||:..:|         :.|:|:...|    ..|.|.|.: .|:. |:.|:.:..:|..
 Frog   490 YLSACFAGCTKMNL---------AGCSCLSSVPVENNTVVPGKCPSPGCQEAFLTFLCVMCVCSM 545

  Fly   681 MHSTSEVGSMLLVMRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIWKSVCGKHGA 745
            :.:.::..|:::::|...|:.|:.|:||:...:.|.|.:|.|:|:||.:||.||.|.:.||..||
 Frog   546 IGAMAQTPSVIILIRAVSPELKSYALGVLFLLLRLIGFIPPPLIFGAGIDSTCLFWSTFCGTQGA 610

  Fly   746 CSLYDADTFRQYFLGITAGIMFLAFLMDLVVW---RKAHRIDIAPEDPQEGG 794
            |:|||...:|..::.|...:..|||::....|   ||.::..|   ...|||
 Frog   611 CALYDNVAYRYLYVSIAITLKSLAFILYTTTWQCLRKNYKRYI---KNHEGG 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_648989.1	OATP	175..754	CDD:460821	192/614 (31%)
slco3a1	XP_002933360.2	MFS_SLCO3_OATP3	36..560	CDD:340960	166/557 (30%)