Protein Alignment Oatp74D and slco4c1

DIOPT Version :10

• Sequence 1: NP_648989.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: XP_002933490.4
• Gene: slco4c1 / 100485817
• XenbaseID: XB-GENE-983309
• Length: 783
• Species: Xenopus tropicalis
• Alignment Length: 732
• Identity: 192/732 - (26%)
• Similarity: 327/732 - (44%)
• Gaps: 105/732 - (14%)

  Fly   100 SSNNNGT--GNGHSLSE--KYAHEQAPLTG-------------GYKLPPRSSESEESDFDSDLNG 147
            :|...||  |..:|:::  .|:|....|.|             |.:.|..|...|....|.|...
 Frog    70 ASRGGGTQAGTHNSVTQGCLYSHSGNRLRGSHTRLSCKVYVMEGVENPSFSCAGEVGLKDLDSKK 134

  Fly   148 GSSAESSSS-------------CGLFGCRPRWARRFASTHVFMVVFLLAYILQGMYMTYFVS-VI 198
            ....|||.|             ||.....|...:...:...::|::.|..::||..:...|: ||
 Frog   135 VEEPESSPSLAVASGEEYKEGPCGWGSFTPSCVQCCNNPKGYLVMYSLLAVMQGTAVNGLVNVVI 199

  Fly   199 TTIEKLFQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALPHFI 263
            :||||.|.:.|..||::.::.::.....::.::::..|||:|||:|...::..:.:...::|:|.
 Frog   200 STIEKRFDLNSSLTGLIAASYDIAFCLLSLFVSFYGQRGHKPRWLAFSALMIGLGSLVFSIPNFF 264

  Fly   264 FGEQLMHSSVILQQTQVSPPNNSFSSHWLNASSEQVNPNLCILGGNQTHSGSECNEERQLEQASH 328
            .|              :....|..|             :.|.:.||.:          .|:..|.
 Frog   265 SG--------------IYEYGNKVS-------------DFCEVSGNSS----------SLQNCSA 292

  Fly   329 SKITVIVLCIFFGSLLSSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGS 393
            .......|.:|....|..|:|.|.:.|||..|.||::...:|.:|:.:..||.::|||.|::.|.
 Frog   293 GSSQSYFLYVFVLGQLLMGVGGTPLYTLGTAYFDDSLPPHKSSLYIGIAYGMSVVGPAIGYLVGG 357

  Fly   394 FCTRWYVNF---SNPGFDATDPRWIGAWWLGPVAIGSLMLLASIAMFS-FPKQLRGKQKPPGQTA 454
            .....|::.   .:.....|||||:||||:|.:..| |:....||.|| |||.|.|.:|...:..
 Frog   358 QLLNIYIDIDKGQSVNITETDPRWLGAWWIGFLICG-LVTWLLIAPFSCFPKHLPGTEKMQSERI 421

  Fly   455 TPA------APVEPEEKPK-LKDFPKTVRRQLSNDILMFRTASCVFHLLPIAGLYTFLPKYLETQ 512
            :.|      :.||.:...| .||||..:...:.|.:|:..|.:..|..........||||::|.|
 Frog   422 SQAHNNGSESIVESKNLGKSFKDFPLALLLLVKNPVLISLTFASCFDAFITTAFAAFLPKFIENQ 486

  Fly   513 FRLATYDANMIAAFCGILV--MGIGIVISGLFILKRKPTARGVAAWIAFTALVYSAGMIILMFIG 575
            |.|.:..:.::..  |:|:  ..||.|:.|:.:.|.|...:.:..:.....::..|...:.:|..
 Frog   487 FSLTSSFSAILGG--GVLIPAAAIGQVLGGVIVSKCKFDCKNIIKFSIIITVISLALASVFIFAR 549

  Fly   576 CSMNDFAGYKPSDGNSPALIEPTCSAALNCTCDKENFAPIC-ADGKMYISACHAGCSSSSLRPSD 639
            |..:.|||.......:..:.|.......||:|.:..:.|:| :||..|.|:|:|||  :|:..:|
 Frog   550 CGNDPFAGVSVQYNGTGKIGELDAPCNSNCSCARFFYDPVCGSDGVQYFSSCYAGC--TSVEYND 612

  Fly   640 NRTLYSDCACIPD---------APEAVNGYCDNNCKNFIYFILIF---AICVFMHSTSEVGSMLL 692
            ...:|.:|:||..         ..:|..|.|:..|.|.|.|::.|   .:..||.:|.   ..:.
 Frog   613 KGKIYGNCSCIASHTGEFGVNVTSQAEQGKCEAKCNNLITFMVFFFFVVVATFMTATP---ITMA 674

  Fly   693 VMRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIWK-SVCGKHGACSLYDAD--TF 754
            ::||...|.::.|:||..|.|.|.|::|.||::|.|:||:|::|. :.||..|||..|...  :.
 Frog   675 ILRCVPDKQRSFALGVQWSLIRLLGSIPGPIVFGVVIDSSCILWNINECGVEGACWTYKNSEMSL 739

  Fly   755 RQYFLGITAGIMFLAFL 771
            ...|:.....::.:|||
 Frog   740 NLVFISAACKVLTIAFL 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_648989.1	OATP	175..754	CDD:460821	166/608 (27%)
slco4c1	XP_002933490.4	MFS_SLCO4C_OATP4C	173..677	CDD:341021	141/548 (26%)