DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp74D and slco4c1

DIOPT Version :9

Sequence 1:	NP_001163460.1	Gene:	Oatp74D / 39954	FlyBaseID:	FBgn0036732	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	XP_002933490.4	Gene:	slco4c1 / 100485817	XenbaseID:	XB-GENE-983309	Length:	783	Species:	Xenopus tropicalis

Alignment Length:	732	Identity:	192/732 - (26%)
Similarity:	327/732 - (44%)	Gaps:	105/732 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 SSNNNGT--GNGHSLSE--KYAHEQAPLTG-------------GYKLPPRSSESEESDFDSDLNG 147
            :|...||  |..:|:::  .|:|....|.|             |.:.|..|...|....|.|...
Frog    70 ASRGGGTQAGTHNSVTQGCLYSHSGNRLRGSHTRLSCKVYVMEGVENPSFSCAGEVGLKDLDSKK 134

  Fly   148 GSSAESSSS-------------CGLFGCRPRWARRFASTHVFMVVFLLAYILQGMYMTYFVS-VI 198
            ....|||.|             ||.....|...:...:...::|::.|..::||..:...|: ||
Frog   135 VEEPESSPSLAVASGEEYKEGPCGWGSFTPSCVQCCNNPKGYLVMYSLLAVMQGTAVNGLVNVVI 199

  Fly   199 TTIEKLFQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALPHFI 263
            :||||.|.:.|..||::.::.::.....::.::::..|||:|||:|...::..:.:...::|:|.
Frog   200 STIEKRFDLNSSLTGLIAASYDIAFCLLSLFVSFYGQRGHKPRWLAFSALMIGLGSLVFSIPNFF 264

  Fly   264 FGEQLMHSSVILQQTQVSPPNNSFSSHWLNASSEQVNPNLCILGGNQTHSGSECNEERQLEQASH 328
            .|              :....|..|             :.|.:.||.:          .|:..|.
Frog   265 SG--------------IYEYGNKVS-------------DFCEVSGNSS----------SLQNCSA 292

  Fly   329 SKITVIVLCIFFGSLLSSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGS 393
            .......|.:|....|..|:|.|.:.|||..|.||::...:|.:|:.:..||.::|||.|::.|.
Frog   293 GSSQSYFLYVFVLGQLLMGVGGTPLYTLGTAYFDDSLPPHKSSLYIGIAYGMSVVGPAIGYLVGG 357

  Fly   394 FCTRWYVNF---SNPGFDATDPRWIGAWWLGPVAIGSLMLLASIAMFS-FPKQLRGKQKPPGQTA 454
            .....|::.   .:.....|||||:||||:|.:..| |:....||.|| |||.|.|.:|...:..
Frog   358 QLLNIYIDIDKGQSVNITETDPRWLGAWWIGFLICG-LVTWLLIAPFSCFPKHLPGTEKMQSERI 421

  Fly   455 TPA------APVEPEEKPK-LKDFPKTVRRQLSNDILMFRTASCVFHLLPIAGLYTFLPKYLETQ 512
            :.|      :.||.:...| .||||..:...:.|.:|:..|.:..|..........||||::|.|
Frog   422 SQAHNNGSESIVESKNLGKSFKDFPLALLLLVKNPVLISLTFASCFDAFITTAFAAFLPKFIENQ 486

  Fly   513 FRLATYDANMIAAFCGILV--MGIGIVISGLFILKRKPTARGVAAWIAFTALVYSAGMIILMFIG 575
            |.|.:..:.::..  |:|:  ..||.|:.|:.:.|.|...:.:..:.....::..|...:.:|..
Frog   487 FSLTSSFSAILGG--GVLIPAAAIGQVLGGVIVSKCKFDCKNIIKFSIIITVISLALASVFIFAR 549

  Fly   576 CSMNDFAGYKPSDGNSPALIEPTCSAALNCTCDKENFAPIC-ADGKMYISACHAGCSSSSLRPSD 639
            |..:.|||.......:..:.|.......||:|.:..:.|:| :||..|.|:|:|||  :|:..:|
Frog   550 CGNDPFAGVSVQYNGTGKIGELDAPCNSNCSCARFFYDPVCGSDGVQYFSSCYAGC--TSVEYND 612

  Fly   640 NRTLYSDCACIPD---------APEAVNGYCDNNCKNFIYFILIF---AICVFMHSTSEVGSMLL 692
            ...:|.:|:||..         ..:|..|.|:..|.|.|.|::.|   .:..||.:|.   ..:.
Frog   613 KGKIYGNCSCIASHTGEFGVNVTSQAEQGKCEAKCNNLITFMVFFFFVVVATFMTATP---ITMA 674

  Fly   693 VMRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIWK-SVCGKHGACSLYDAD--TF 754
            ::||...|.::.|:||..|.|.|.|::|.||::|.|:||:|::|. :.||..|||..|...  :.
Frog   675 ILRCVPDKQRSFALGVQWSLIRLLGSIPGPIVFGVVIDSSCILWNINECGVEGACWTYKNSEMSL 739

  Fly   755 RQYFLGITAGIMFLAFL 771
            ...|:.....::.:|||
Frog   740 NLVFISAACKVLTIAFL 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_001163460.1	OATP	175..754	CDD:335235	166/608 (27%)
slco4c1	XP_002933490.4	MFS_SLCO4C_OATP4C	173..677	CDD:341021	141/548 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910