DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp74D and slco1f2

DIOPT Version :9

Sequence 1:	NP_001163460.1	Gene:	Oatp74D / 39954	FlyBaseID:	FBgn0036732	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001121745.2	Gene:	slco1f2 / 100190901	ZFINID:	ZDB-GENE-080305-3	Length:	662	Species:	Danio rerio

Alignment Length:	691	Identity:	208/691 - (30%)
Similarity:	321/691 - (46%)	Gaps:	82/691 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 SDLNGGSSAESSSSCGLFGCRPRWARRFASTHVFMVVFLLAYILQGMYMTYFVSVITTIEKLFQI 207
            ||.|   ...|.:.|    |.||       ..:|:......|..:.|..:|..|.||.||:.|:|
Zfish    11 SDRN---QKTSQTKC----CPPR-------LKIFIAALAFCYFSKSMTASYTKSTITQIERRFEI 61

  Fly   208 KSKTTGILLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALPHFIFGEQLMHSS 272
            .|.|.||:....|||.:....|::|...:.|||:.|..|::|..|.....|.||||.|.
Zfish    62 PSSTVGIIDGGFEMGNMLVITLVSYVGAKFHRPKIIGAGVLLMGIGTLLMASPHFIMGR------ 120

  Fly   273 VILQQTQVSPPNNSFSSHWLNASSEQVNPNLCILGGNQTHSGSECNEERQLEQASHSKITVIVLC 337
             ....|..:..|::.:...::..|......|     .|..||  |.:    |:|..|.:.|||:
Zfish   121 -YKYGTAATHTNDAGNFTVISTCSSDSQKTL-----QQPFSG--CRK----EEAESSPLWVIVV- 172

  Fly   338 IFFGSLLSSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRWY--- 399
              .|:.: .|||:.::..||:.::||....:.|..|:.....::.:||..||:.||.|...|
Zfish   173 --LGNTM-LGIGEASIIPLGMSFVDDYARPENSAFYIGCLNTIKGIGPIFGFVLGSLCANLYVDI 234

  Fly   400 --VNFSNPGFDATDPRWIGAWWLGPVAIGSLMLLASIAMFSFPKQLRGKQKPPGQ--TATPAAPV 460
              ||..:......|.||:||||||.|..|.|.:||:...:..||.|     |...  :.....|.
Zfish   235 GLVNKESVTITPQDSRWVGAWWLGYVVSGLLTVLAAFPFWFLPKAL-----PENSQISLLDNTPQ 294

  Fly   461 EPEEKPKL----KDFPKTVRRQLSNDILMFRTASCVFHLLPIAGLYTFLPKYLETQFRLATYDAN 521
            :.:..|.|    |||..|.:|.|:|.|.:...|..:......|.|.|:.|||||.||..:...||
Zfish   295 QHKTTPSLTEIVKDFAPTFKRLLTNKIYILYLAYSIVAFNDFAILVTYTPKYLEQQFGQSASKAN 359

  Fly   522 MIAAFCGILVMGIGIVISGLFILKRKPTARGVAAWIAFTALVYSAGMIILMF-IGCSMNDFAGYK 585
            .:.....:..:.:|:.:||| ::||.......:|.:....:|.:..:.:..| :.|...|.||..
Zfish   360 FLIGVTCVPAVALGVFLSGL-MMKRFKWGLLASARVNLLTIVATVFLTVPFFALSCENLDIAGVT 423

  Fly   586 -PSDGNSPAL-----IEPTCSAALNCTCDKENFAPICAD-GKMYISACHAGCSSSSLRPSDNRTL 643
             |..|::...     :.|:|:|  :|.|...::.|:|.: |..|||.|||||||:. ....|:|
Zfish   424 VPYQGSTEVQGVTSDVLPSCNA--DCGCPDLHWDPVCGENGVTYISPCHAGCSSTQ-GAGRNKT- 484

  Fly   644 YSDCACIPD------APEAVNGYCDN--NCKNFIYFIL-IFAICVFMHSTSEVGSMLLVMRCTHP 699
            :.||.||..      ...||.|.|..  ||...:|..| :.::.:|::|...|....:.:|...|
Zfish   485 FHDCGCIQSWGLSVGNSSAVLGQCSQNPNCNRMMYLYLGLQSLALFVYSLGAVPLFTMSLRIVDP 549

  Fly   700 KDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIW--KSVCGKHGACSLYDADTFRQYFLGIT 762
            :.|::::||:..:|.:.|.:|.||.:||:|||:||.|  :..||: |||.:||.:|||..|.|:|
Zfish   550 ELKSLSVGVLLLSIRVLGGIPAPIYFGALVDSSCLKWGQRKSCGR-GACRIYDIETFRFLFQGLT 613

  Fly   763 AGIMFLA--FLMDLVVW--RKAHRIDIAPEDPQ-EGGPASN 798
            ..:..||  .|....:|  ||........||.: :.||:.:
Zfish   614 NCLRVLACSLLWIATIWIKRKIQNDKQISEDMELQRGPSDD 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_001163460.1	OATP	175..754	CDD:335235	184/608 (30%)
slco1f2	NP_001121745.2	OATP	29..605	CDD:281175	184/608 (30%)
		MFS	31..>413	CDD:119392	117/409 (29%)
		KAZAL_SLC21	440..492	CDD:238650	23/55 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D434101at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920