Protein Alignment Oatp74D and slco4a1

DIOPT Version :10

• Sequence 1: NP_648989.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_001120155.1
• Gene: slco4a1 / 100145193
• XenbaseID: XB-GENE-5905026
• Length: 709
• Species: Xenopus tropicalis
• Alignment Length: 785
• Identity: 212/785 - (27%)
• Similarity: 349/785 - (44%)
• Gaps: 141/785 - (17%)

  Fly    72 YESTPSNNNEWKAPEDLGHLKNGLGNILSSNNNGTGNGHSLSEKYAHEQAPLTGGYKLPPRSSES 136
            ||...|.:.|  .||.|..:                   |..|.|..:...:|.  |:.|..:::
 Frog    24 YELESSESQE--QPETLAPI-------------------SSPESYEPQNNNITP--KIKPLENDA 65

  Fly   137 EESDFDSDLNGGSSAESSSSCGLFGCRPRWARRFASTHVFMVVFLLAYILQGMYMTYFV-SVITT 200
            .|..|       ..:|..:.||.....|:..:.|.:....:|....|..||||.:..|: :||||
 Frog    66 REIKF-------VPSERENRCGWGLLTPKCLQVFNNPKGVLVFLCAASFLQGMTVNGFLNTVITT 123

  Fly   201 IEKLFQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALPHFIFG 265
            ||:.|.::|..||::.|:.::........::||.|.||:|||:..|:.:..|.:|..|||||
 Frog   124 IERRFYLRSYHTGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVFIMGIGSFIFALPHF--- 185

  Fly   266 EQLMHSSVILQQTQVSPPNNSFSSHWLNASSEQVNPNLCILGGNQTHSGSECNEERQLEQASHSK 330
                             .|:|:          ::|.|.       ...|...|..:||.: |.|.
 Frog   186 -----------------SNDSY----------EINFNF-------DTEGCRSNRTQQLPE-SASS 215

  Fly   331 ITVIVLCIFFGSLLSSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFC 395
            ::........|..| .|||.|.:.|||:.|:|:||.|..||:|:.:.....|:|||.|::.|.|.
 Frog   216 LSNYRFVFMLGQFL-HGIGATPLYTLGVTYLDENVKSSNSPVYIGIFYTAAIVGPAVGYLLGGFF 279

  Fly   396 TRWYVNFS-----NPGFDATDPRWIGAWWLGPVAIGSLMLLASIAMFSFPKQLRGKQKPPGQTAT 455
            ...|.:.|     .||    :|.|:||||:|.:|.|....|.|:.:.::|:||.|.|:......:
 Frog   280 LNIYTDISRQTDLTPG----NPLWVGAWWIGFLAAGVAGFLISLPILAYPQQLPGSQRYMVMRVS 340

  Fly   456 PAAPV-------EPEEKPKLKDFPKTVRRQLSNDILMFRTASCVFHLLPIAGLYTFLPKYLETQF 513
            .|..|       :||....:||.||::...|.|...:|...:.......|.|:.||.||:||:||
 Frog   341 EAHQVKDSDSIKDPEFGKTIKDLPKSLLMLLKNPTFVFLCLAGATEATLITGMSTFGPKFLESQF 405

  Fly   514 RLATYDANMIAAFCGILVM---GIGIVISGLFILKRKPTARGVAAWIAFTALVYSAGMI--ILMF 573
            .|:   |:..|...|.||:   |.|..:.|..:.|.|   ...:|.|.|..:....|::  .:..
 Frog   406 SLS---ASQAATCFGYLVVPAGGGGTFLGGFIVNKLK---LNCSAAIKFCVICTVIGLLSMFVFL 464

  Fly   574 IGCSMNDFAGYKPSDGNSP----ALIEPT------CSAALNCTCDKENFAPICADGKM-YISACH 627
            :.|...:..|.     |:|    .|:|.:      |:|  :|.|.:|.::|:|.:|.: |.||||
 Frog   465 LSCPNLELVGV-----NAPYRESVLLEGSQNLTALCNA--DCRCLEEIYSPVCVEGNITYYSACH 522

  Fly   628 AGCSSSSLRPSDNRTLYSDCACIPDAPEAVNGYCDNNCKN------FIYFILIFA-ICVFMHSTS 685
            ||||.:.....:::.:|.:|:|:..| ..|.|.|.:.|..      |::.:::|. :|
 Frog   523 AGCSEAYSDIRNDQKVYQNCSCVAGA-VVVAGKCLSPCNTMPLLLAFVFLVILFTFLC------- 579

  Fly   686 EVGSMLLVMRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIWKSVCGKHGACSLYD 750
            .|.::...:||.....::.|:|:........|.:|.||.:|:::|.:||.|:...|.:|:|..|.
 Frog   580 SVPALTATLRCVSDNQRSFALGIQWILARALGAIPGPIAFGSMIDISCLRWQKQGGANGSCYFYQ 644

  Fly   751 ADTFRQYFLGITAGIMF-----LAFLMDLVVWRKAHRIDIAPEDPQEGGPASNGRTLEVSESKQP 810
            ......|.|  .||:::     |.||..|.:::..   .::|...|:|.....|...|:.:.:.
 Frog   645 NSDMSNYML--MAGLVYKVLGLLFFLFALFLYKPP---PLSPSGEQKGTNCIKGNAEEIHKGRD- 703

  Fly   811 ITPAP 815
            ||..|
 Frog   704 ITSTP 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_648989.1	OATP	175..754	CDD:460821	176/614 (29%)
slco4a1	NP_001120155.1	MFS_SLCO4A_OATP4A	95..589	CDD:341020	159/557 (29%)