Protein Alignment Oatp74D and slco1a2

DIOPT Version :10

• Sequence 1: NP_648989.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: XP_031753397.1
• Gene: slco1a2 / 100124879
• XenbaseID: XB-GENE-6454871
• Length: 685
• Species: Xenopus tropicalis
• Alignment Length: 730
• Identity: 198/730 - (27%)
• Similarity: 321/730 - (43%)
• Gaps: 116/730 - (15%)

  Fly   131 PRSSESEESDFDSDLNGGSSAESSSSCGLFGCRPRWARRFASTHVFMVVFLLAYILQGMYMTYFV 195
            ||...:.....:..:..|.:|.:.|.        :..|..:...||:.....||:.:.:.:.|..
 Frog     9 PRPGNTPRYKVNPMVTMGQAATNGSD--------KKPRGISKLKVFIFALSFAYVAKTLALAYSN 65

  Fly   196 SVITTIEKLFQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALP 260
            ||||.||:.|.|.|.|.|.:..:.::|.:.....::||..:.|||:.||.|.::.|:.:...|||
 Frog    66 SVITQIERRFSIPSSTAGFIEGSFDIGNVLLIAFVSYFGAKLHRPKVIALGCLIMSLGSCLEALP 130

  Fly   261 HFIFGEQLMHSSVILQQTQVSPPNNSFS-------SHWLNASSEQVNPNLCILGGNQTHSGSECN 318
            ||:.......|:       ||.||.:.|       :|.|::|:|   |.            .||
 Frog   131 HFLMPRYEYGSA-------VSSPNQTTSGAPLCLANHSLSSSAE---PQ------------GEC- 172

  Fly   319 EERQLEQASHSKITVIVLCIFFGSLLSSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRIL 383
                 ...|.|.:.:.||   .|:|| .|||:|.|..||:.|||:...::.||.|:.:...:.|.
 Frog   173 -----RGGSMSLMWIFVL---VGNLL-RGIGETPVEPLGLSYIDEFSQTENSPFYIGIIQTLSIA 228

  Fly   384 GPASGFIFGSFCTRWYVNFSNPGFDAT-----DPRWIGAWWLGPVAIGSLMLLASIAMFSFPKQL 443
            ||..|::..:.||:.||:..:...|..     |.||:||||:|.:..|:..|||::..:..|:.|
 Frog   229 GPLLGYLLAALCTKLYVDIGSINLDEVTVTQRDIRWVGAWWVGFLVSGAACLLAALPFWCLPRSL 293

  Fly   444 --RGKQ--KPPGQTATPAAPVEPE-----EKPK--LKDFPKTVRRQLSNDILMFRTASCVFHLLP 497
              .|.:  ..|.:|...|.| ||:     .||.  |::|.:.:|....|.|.:......|.....
 Frog   294 PKEGAENGSEPSETVALATP-EPQGPNTPTKPALGLREFLRMIRGLFRNKIYVLFMIVTVLQFNA 357

  Fly   498 IAGLYTFLPKYLETQFRLATYDANMIAAFCGILVMGIGIVISGLFILKRKPTARGVAAWIAF--- 559
            .:|...||||::|.|:..::.:|..:.....:.::.:|..:.| :.:||...:...||.|.|
 Frog   358 FSGYIAFLPKFVEQQYGKSSSEAIFLIGVYNLPIISLGYFLGG-YYMKRFKVSTYRAAQIGFYSE 421

  Fly   560 --TALV-YSAGMIILMFIGCSMNDFAGYKPSDGNSPAL-----IEPTCSAALNCTCDKENFAPIC 616
              |.|: |||     .|:||..:..||...|.|.:..:     ....|:|.  |.|..:.:.|:|
 Frog   422 ILTYLINYSA-----FFMGCENSLVAGVTVSYGGTGDISYSQNFTSGCNAP--CGCPGDVWDPVC 479

  Fly   617 AD-GKMYISACHAGCSSS----------SLRPSDNRTLYSDCACIPDAPEAVNGY-------CDN 663
            .: |..|||||||||::|          .|....:.|..:.|...|..|.|...:       |..
 Frog   480 GENGLAYISACHAGCATSVGEGQNTLFCMLDSPRSSTTAAVCGPPPSQPMAARRWASAPGRRCVT 544

  Fly   664 NC--KNFIYFILIFAICVFMHSTSEVGSMLLVMRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYG 726
            .|  .::        .|....::|.............|::|::.:|:......:.|.:|..:.:|
 Frog   545 PCWWPSW--------SCPSSAASSSPSEPCRPTWSLKPEEKSLGLGLHLLTARILGGIPSVVSFG 601

  Fly   727 AVVDSACLIWKSV-CGKHGACSLYDADTFRQYFLGITAGIMFLAF----LMDLVVWRKAHRIDIA 786
            |:.||.||.|..: ||:.|||.:||.|.||..|.||...|...::    |:.|::.|:....|.|
 Frog   602 ALADSTCLKWGVLGCGERGACRMYDTDLFRYLFHGIENIIRTSSYIPCVLILLILKREQAPQDSA 666

  Fly   787 PEDPQEGGPASNGRT 801
            |...:.||...:..|
 Frog   667 PPTERVGGTRDDSVT 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_648989.1	OATP	175..754	CDD:460821	177/633 (28%)
slco1a2	XP_031753397.1	MFS	42..528	CDD:475125	151/526 (29%)