DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SecCl and Gabrp

DIOPT Version :9

Sequence 1:	NP_001261986.1	Gene:	SecCl / 39949	FlyBaseID:	FBgn0036727	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_112291.1	Gene:	Gabrp / 81658	RGDID:	620532	Length:	440	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	123/492 - (25%)
Similarity:	210/492 - (42%)	Gaps:	103/492 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LIQRL--------THVCRYDRLERP-FEYDSDG--KRL-------PIVVKTRIYVYFLQNLNSDL 93
            |.||:        ..|.|.|:|..| ||..:.|  |.|       |:.:...:.:..:.:::...
  Rat    15 LAQRMCIQGNQFNVEVSRSDKLSLPGFENLTAGYNKFLRPNFGGDPVRIALTLDIASISSISESN 79

  Fly    94 LQFKMHALLQLRFQDKRLAYKAFNRSDNILGQKHLSERLWLPHIFFANERESSILGTDEKDVLTS 158
            :.:.....|:.|:.|.||.::. |:|..:  ...|.|.||:|..:....::|.:......:.|..
  Rat    80 MDYTATIYLRQRWTDPRLVFEG-NKSFTL--DARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIR 141

  Fly   159 LSPEGNVIISTRMQASLYCWMNFQKFPFDQQFCSTVLESWMYNTSDLILEW-EPHTPISFDPEMR 222
            |...|.|:.:.|:..::.|.|:..|:|.|.|.|...||||.|:.:|:...| ..:..:.....:|
  Rat   142 LFSNGTVLYALRITTTVTCNMDLSKYPMDTQTCKLQLESWGYDGNDVEFSWLRGNDSVRGLENLR 206

  Fly   223 LTEYNMAQFWHNTTIVQSDGDNLRHGAFAGNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWV 287
            |.:|.:.|::...|:.|.:         .|||:.|.....|:|.:.:::|:.|:||..:|.:|||
  Rat   207 LAQYTIQQYFTLVTVSQQE---------TGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWV 262

  Fly   288 SFWLQADASPPRIMLGTSTMLSFITLSSSQSKNLPKVS-YIKVSEVWFLGCTFFIFGSLVEFAFV 351
            |||:..::.|.|..:|.:|:||..||......:||..: :||..:|:...|..|:||:|:|:|..
  Rat   263 SFWISLESVPARTCIGVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVA 327

  Fly   352 N-------TIWRRKENIELKKVNSKYIIKSTLTPRPARRQIGGSLSNESRARSCSSL----DNIV 405
            :       .:..|....:.::||...||.|             |:|:..|..|.:|:    ||:
  Rat   328 HYSSLQQMAVKDRGPAKDSEEVNITNIINS-------------SISSFKRKISFASIEISGDNV- 378

  Fly   406 SSTESVRNGNGTVNQGFNNY--LTVHPNLPIIRTECAEADTVSICSARTNNDHIVDVDKDKKDTP 468
                              ||  ||:            :|........|.....|:|.
  Rat   379 ------------------NYSDLTM------------KASDKFKFVFREKIGRIIDY-------- 405

  Fly   469 PTFTTMTPQEIAMWIDRRSRFLFPAMFLAFNALYWTF 505
              ||...|..    :||.|:.|||.:|:..|..||.:
  Rat   406 --FTIQNPSN----VDRYSKLLFPLIFMLANVFYWAY 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	123/490 (25%)
		Neur_chan_LBD	44..267	CDD:280998	58/238 (24%)
		Neur_chan_memb	275..503	CDD:280999	62/241 (26%)
Gabrp	NP_112291.1	LIC	43..437	CDD:273305	113/464 (24%)
		LGIC_ECD	60..241	CDD:355788	44/192 (23%)
		Cys-loop	159..174	CDD:349787	6/14 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810