Protein Alignment SecCl and GLRA3

DIOPT Version :9

• Sequence 1: NP_001261986.1
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_006520.2
• Gene: GLRA3 / 8001
• HGNCID: 4328
• Length: 464
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 137/514 - (26%)
• Similarity: 227/514 - (44%)
• Gaps: 89/514 - (17%)

  Fly    10 FWITLILVLSIWTSVGVKAEEEECPSMADAGSLQQTQLIQRLT-HVCRYDRLERPFEYDSDGKRL 73
            ||...:|:..:.|.....|.....|       :..:..:.:|. ....||...||     :.|..
Human    16 FWEAALLLSLVATKETDSARSRSAP-------MSPSDFLDKLMGRTSGYDARIRP-----NFKGP 68

  Fly    74 PIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKAFNRSDNILGQKHLSERLWLPHIF 138
            |:.|...|::....::....:.::::..|:.::.|.||||..: ..|::.....:.:.:|.|.:|
Human    69 PVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEY-PDDSLDLDPSMLDSIWKPDLF 132

  Fly   139 FANERESSI--LGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQFCSTVLESWMYN 201
            ||||:.::.  :.||.|  |..:...|||:.|.|:..:|.|.|:.:.||.|.|.|...|||:.|.
Human   133 FANEKGANFHEVTTDNK--LLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYT 195

  Fly   202 TSDLILEWEPHTPISFDPEMRLTEYNMAQFWHNTTIVQSDGDNLRHGA---FAGNYSSLSFTVNL 263
            .:|||.||:...|:.....:.|.::          :::.:.| ||:..   ..|.::.:....:|
Human   196 MNDLIFEWQDEAPVQVAEGLTLPQF----------LLKEEKD-LRYCTKHYNTGKFTCIEVRFHL 249

  Fly   264 KREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSKNLPKVSYIK 328
            :|::|:||:..|:||::||.:||||||:..||:|.|:.||.:|:|:..|.||....:||||||:|
Human   250 ERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVK 314

  Fly   329 VSEVWFLGCTFFIFGSLVEFAFVNTIWRRKENIELKKVNSKYIIKSTLTPRPARRQIGGSLSNES 393
            ..::|...|..|:|.:|:|:|.||.:.|:.              |..|..|..|:       |::
Human   315 AIDIWMAVCLLFVFSALLEYAAVNFVSRQH--------------KELLRFRRKRK-------NKT 358

  Fly   394 RARSCSSLDNIVSSTESVRN--------GNGTVNQGFNNYLTVHPNLPIIRTECAEADTVSICSA 450
            .|.:...........:.||.        |.|...|..:......||.|           |.:...
Human   359 EAFALEKFYRFSDMDDEVRESRFSFTAYGMGPCLQAKDGMTPKGPNHP-----------VQVMPK 412

  Fly   451 RTNNDHIVDVDKDKKDTPPTFTTMTPQEIAMWIDRRSRFLFPAMFLAFNALYWTFVYVL 509
            ..:....|.:|:.||                 ||..||..||..||.||..||....:|
Human   413 SPDEMRKVFIDRAKK-----------------IDTISRACFPLAFLIFNIFYWVIYKIL 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	130/475 (27%)
		Neur_chan_LBD	44..267	CDD:280998	57/228 (25%)
		Neur_chan_memb	275..503	CDD:280999	68/235 (29%)
GLRA3	NP_006520.2	LIC	12..451	CDD:273305	136/509 (27%)
		Strychnine-binding. /evidence=ECO:0000269|PubMed:26416729	235..240		1/4 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910