Protein Alignment SecCl and Gabrg3

DIOPT Version :10

• Sequence 1: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_077346.3
• Gene: Gabrg3 / 79211
• RGDID: 621735
• Length: 467
• Species: Rattus norvegicus
• Alignment Length: 533
• Identity: 128/533 - (24%)
• Similarity: 221/533 - (41%)
• Gaps: 108/533 - (20%)

  Fly    14 LILVLSIWTSVGVKA------EEEECPSMAD---AGSLQQTQLIQRLTHVCR-YDRLERPFEYDS 68
            |:|:|.:::.:..::      :.|:.||...   |...|.|.:...|..:.| ||:..||
  Rat     5 LLLLLCLFSGLHARSRRVEEDDSEDSPSNQKWVLAPKSQDTDVTLILNKLLREYDKKLRP----- 64

  Fly    69 DGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAY----KAFNRSDNILGQKHLS 129
            |....|.|:...|||..:..::|..:::::.......:.|.||.:    |....:.|::|
  Rat    65 DIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTMKILTLNSNMVG----- 124

  Fly   130 ERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQFCSTV 194
             .:|:|...|.|.:.:........:.|..:..:|.::.:.|:..:..|.:....||.|...|...
  Rat   125 -LIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDAHACPLT 188

  Fly   195 LESWMYNTSDLILEWEPHTPISFDPE-MRLTEYNMAQFWHNTTIVQSDGDNLRHGAFAGNYSSLS 258
            ..|:.|...::|..|..::..:.|.: .||.:::.....:.|.||.:.         ||:|..::
  Rat   189 FSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTS---------AGDYVVMT 244

  Fly   259 FTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSKNLPK 323
            ....|.|.:|::.:..|:|.::.|.:||||||::.||:|.|..||.:|:|:..|||:...|:||:
  Rat   245 IYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTTLGITTVLTMTTLSTIARKSLPR 309

  Fly   324 VSYIKVSEVWFLGCTFFIFGSLVEFAFVNTIWR-RKENIELKKVNSKYIIKSTLTPRPARRQIGG 387
            |||:...:::...|..|:|.:|:|:|.:|.... ||..|..||.       |.|.| .:.|.|..
  Rat   310 VSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTIRKKKT-------SLLHP-DSTRWIPD 366

  Fly   388 SLSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNY--LTVHPNLPIIRTECAEADTVSICSA 450
            .:|                            .|..:||  |.:.|..|::.|
  Rat   367 RIS----------------------------LQAPSNYSLLDMRPPPPVMIT------------- 390

  Fly   451 RTNN--------DHIVDVDKDKKDTPPTFTTMTPQEIAMW-----------IDRRSRFLFPAMFL 496
             .||        |..|....|.||....|......:...|           :|..||..||..||
  Rat   391 -LNNSMYWQEFEDTCVYECLDGKDCQSFFCCYEECKSGSWRRGRIHIDVSELDSYSRVFFPTSFL 454

  Fly   497 AFNALYWT-FVYV 508
            .||.:||. ::|:
  Rat   455 LFNLVYWVGYLYL 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_648984.2	LIC	43..505	CDD:455710	120/490 (24%)
Gabrg3	NP_077346.3	LIC	50..464	CDD:455710	118/483 (24%)
		LGIC_ECD_GABAAR_G	71..252	CDD:349801	37/195 (19%)
		Cys-loop	171..185	CDD:349801	4/13 (31%)