DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SecCl and Gabrq

DIOPT Version :9

Sequence 1:	NP_001261986.1	Gene:	SecCl / 39949	FlyBaseID:	FBgn0036727	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_065234.1	Gene:	Gabrq / 57249	MGIID:	1888498	Length:	638	Species:	Mus musculus

Alignment Length:	610	Identity:	137/610 - (22%)
Similarity:	250/610 - (40%)	Gaps:	156/610 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 CPSMADAGSLQQTQLIQRLTHVCRYDRLERPFEYDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFK 97
            |.:.|:...:|  :::.|:  :..||...||   :..|  .|:.|...|||..::.::...:.:.
Mouse    50 CKNCANEAVVQ--KILDRV--LSTYDVRLRP---NFGG--APVPVSVSIYVSSIEQISEINMDYT 105

  Fly    98 MHALLQLRFQDKRLAYKAFNRSDNILGQKHLSERLWLPHIFFANERESSILGTDEKDVLTSLSPE 162
            :...|...::|.||||  :..:.|:.....:.|:||:|..:|.|.:::.:.....::.:..|.|:
Mouse   106 ITMFLHQTWKDTRLAY--YETNLNLTLDYRMHEKLWVPDCYFVNSKDAFVHDVTVENRVFQLHPD 168

  Fly   163 GNVIISTRMQASLYCWMNFQKFPFDQQFCSTVLESWMYNTSDLILEWEPHTPISFDPEMRLTEYN 227
            |.|....|:..:..|.::.||||.|:|.|...:||:.|...|::|.||....|.....:.:.:|.
Mouse   169 GTVRYGIRLTTTAACSLDLQKFPMDKQSCKLEVESYGYTVEDIVLSWEDDNAIHITDGLHIPQYT 233

  Fly   228 MAQFWHNTTIVQSDGDNLRHGAFAGNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQ 292
                :...||...:     ...:.|:|..|.....::||:..||:..|.|:::...:||:|||:.
Mouse   234 ----YLGRTITSKE-----VYFYTGSYMRLIVKFQVQREVRSYLVQVYWPTVLTTILSWISFWMN 289

  Fly   293 ADASPPRIMLGTSTMLSFITLSSSQSKNLPKVSYIKVSEVWFLGCTFFIFGSLVEFAFVNTI--- 354
            .|:|..|:.:|.:::|...|:.|.....||.:|.||..:::.|.|.||:|.||:|:.::|.:
Mouse   290 YDSSAARVTIGLTSILVLTTIDSHMRDKLPHISCIKAIDIYILVCLFFVFLSLLEYVYINYLFFS 354

  Fly   355 -------------------WRRKE----NIELKKVNSKYIIKSTLTPRP--------ARRQIGGS 388
                               :|.:|    |::...:|.:..::....|.|        |.::..||
Mouse   355 QVPRRNHRRCRKPRRVVARYRYQEVVVANVQDGLINVEDRVEDRAGPLPDSPMQAHLASQESLGS 419

  Fly   389 L---SNESRARSCSSLDNIVSSTESVRNGNG------------TVNQ---GFNNYLTVHPNLPI- 434
            |   |.:::..:..||..:.|::...:...|            ||.:   .|:.:||....:||
Mouse   420 LVFTSEQAQLATSESLSLLSSASSQTQLATGESLSDLPSTSEQTVPECTIHFHGFLTNDSIIPIK 484

  Fly   435 ------------------------------------IRTECAE------------ADTVSICSA- 450
                                                |...|.:            .|.:||.|:
Mouse   485 IHSRSDACDDEDSEESLSSEESHGHGSSHTGRLKLQISQRCVQEASWDLDKIEILQDDISITSSW 549

  Fly   451 -------RTNNDHI----------VDVDKD-----KKDTPP----------TFTTMTPQEIAMWI 483
                   :.:.|.|          .|.:||     :::..|          :|....|..:.. :
Mouse   550 LGLDEQCKGDADSIWSLTDEELMACDQEKDSSSESEENCSPSPGCSFNEGFSFQLFKPNRVPK-V 613

  Fly   484 DRRSRFLFPAMFLAFNALYWTF-VY 507
            ||.||||||..|..||.:||.: ||
Mouse   614 DRWSRFLFPLSFGLFNVVYWLYHVY 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	133/595 (22%)
		Neur_chan_LBD	44..267	CDD:280998	52/222 (23%)
		Neur_chan_memb	275..503	CDD:280999	75/361 (21%)
Gabrq	NP_065234.1	LGIC_ECD_GABAAR_theta	82..263	CDD:349804	45/191 (24%)
		Cys-loop	183..197	CDD:349804	7/13 (54%)
		LGIC_TM_GABAAR_theta	266..365	CDD:349858	30/98 (31%)
		TM1 helix	266..289	CDD:349858	9/22 (41%)
		TM2 helix	293..317	CDD:349858	6/23 (26%)
		TM3 helix	325..351	CDD:349858	10/25 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..515		0/23 (0%)
		LGIC_TM	<604..636	CDD:365787	14/32 (44%)
		TM4 helix	612..633	CDD:349850	11/21 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810