DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SecCl and gabrd

DIOPT Version :9

Sequence 1:	NP_001261986.1	Gene:	SecCl / 39949	FlyBaseID:	FBgn0036727	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	XP_700099.5	Gene:	gabrd / 571422	ZFINID:	ZDB-GENE-081105-170	Length:	459	Species:	Danio rerio

Alignment Length:	523	Identity:	132/523 - (25%)
Similarity:	232/523 - (44%)	Gaps:	104/523 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EIFWITLI--------LVLSIWTSVGVKAEEEECPSMADAGSLQQTQLIQRLTHVCRYDRLERPF 64
            ::||:.||        ::..|...||...|....|::.|.              :..|.|..||
Zfish     9 KLFWLVLIGGDRRSRAMLSDIGDYVGTDIEISWLPNLDDL--------------MKGYARNFRP- 58

  Fly    65 EYDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKAFNRSDNILG-QKHL 128
              ...|.  |:.|...|.|..:.:::...:::.|...|:..::|.||:|   |.::..|| ....
Zfish    59 --GIGGP--PVNVAMAIEVASIDHISEANMEYTMTVFLRQSWRDDRLSY---NHTNKTLGLDSRF 116

  Fly   129 SERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQFCST 193
            .::||||..|..|.:.:.......::.|..|.|:|.::.|:|:.:::.|.|:..|:|.|:|.|..
Zfish   117 VDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSSRITSTVACDMDLTKYPMDEQECML 181

  Fly   194 VLESWMYNTSDLILEW-EPHTPISFDPEMRLTEYNMAQFWHNTTIVQSDGDNLRHGAFAGNYSSL 257
            .|||:.|::.|::..| |....|....::.|:::.:..:...|.::     |.:.   ||.:..|
Zfish   182 DLESYGYSSEDIVYHWSESQKLIHGLDKLELSQFTITDYRFVTEMM-----NFKS---AGRFPRL 238

  Fly   258 SFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSKNLP 322
            |....|:|..|.|::..|:||:::||:||||||:...|.|.|:.||.:|:|:..||..|...:||
Zfish   239 SLRFQLRRNRGVYIIQSYMPSILLVAMSWVSFWISQSAVPARVSLGITTVLTMTTLMVSARSSLP 303

  Fly   323 KVSYIKVSEVWFLGCTFFIFGSLVEFAFV--NTIWRRKENIELK-KVNSKYIIKS-----TLTPR 379
            :.|.||..:|:|..|..|:|.:|:|:||.  |..:.:||..::| ..|::.::|:     .|...
Zfish   304 RASAIKALDVYFWICYVFVFAALIEYAFAHYNADYSKKEKAKVKTNKNAESMVKNGKQAMVLFSL 368

  Fly   380 PARRQIGGSLSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTVHPNLPIIRTECAEADT 444
            .......|.|.:..::||..:.|...::.:                    |:        .|.:|
Zfish   369 SVAGMNQGLLISNRQSRSHRASDAAAAAAD--------------------PH--------EETET 405

  Fly   445 VSICSARTNNDHIVDVDKDKK---------DTPPTFTTMTPQEIAMWIDRRSRFLFPAMFLAFNA 500
            .|..|.|...:.    .::||         ||               ||..:|.:||..|...|.
Zfish   406 RSATSRRAQKES----SEEKKCCKCKPIDADT---------------IDIYARAVFPFTFAVVNV 451

  Fly   501 LYW 503
            :||
Zfish   452 IYW 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	122/480 (25%)
		Neur_chan_LBD	44..267	CDD:280998	54/224 (24%)
		Neur_chan_memb	275..503	CDD:280999	64/244 (26%)
gabrd	XP_700099.5	LIC	45..457	CDD:273305	123/487 (25%)
		Neur_chan_LBD	45..247	CDD:280998	54/231 (23%)
		Neur_chan_memb	256..454	CDD:280999	64/244 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810