Protein Alignment SecCl and gabra6b

DIOPT Version :10

• Sequence 1: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: XP_002667403.3
• Gene: gabra6b / 559693
• ZFINID: ZDB-GENE-080815-1
• Length: 444
• Species: Danio rerio
• Alignment Length: 519
• Identity: 124/519 - (23%)
• Similarity: 213/519 - (41%)
• Gaps: 108/519 - (20%)

  Fly    11 WITLILVLSIWTSVGVKAEEEECPSMADAGSLQQTQL-IQRLTHVC-----RYDRLERPFEYDSD 69
            |:...|.||             |.....|....:|:: :..:|.:.     .||...||
Zfish     3 WVRTCLFLS-------------CVGQVVANPPTETRIYLDNITRILDRLLDGYDNRLRP------ 48

  Fly    70 GKRLPIV-VKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKA---FNRSDNILGQKHLSE 130
            |...|:. |||.|:|.....::...:::.|....:..:.|.||.::.   ..|.:|::..|
Zfish    49 GFGGPVTEVKTDIFVTSFGPVSDVEMEYTMDVFFRQTWIDDRLKFEGPIEILRLNNLMVSK---- 109

  Fly   131 RLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQFCSTVL 195
             :|.|..||.|.:.|........:.|..:...|.::.:.|:..:..|.|....||.|...|....
Zfish   110 -IWTPDTFFRNGKRSISHNMTTPNKLFRIMQNGTILYTMRLTINAECPMRLINFPMDGHSCPLKF 173

  Fly   196 ESWMYNTSDLILEWEPHTPISFDPEMRLTEYNMAQFWHNTTIVQSDGDNLRHGAFAGNYSSLSFT 260
            .|:.|..|:::..|: ..|: |..|:.....::.|:    .::.....:.|..:..|.|..::..
Zfish   174 GSYAYPMSEIVYTWK-KGPL-FSVEVPQESSSLLQY----DLIGQTVSSERLKSNTGEYIVMTVY 232

  Fly   261 VNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSKNLPKVS 325
            .:|:|::||:|:..|:|.:|.|.::.||||:..::.|.|.:.|.:|:|:..|||.|...:|||||
Zfish   233 FHLQRKMGFFLIQTYIPCIMTVILAQVSFWIDKESVPARTVFGITTVLTMTTLSISARHSLPKVS 297

  Fly   326 YIKVSEVWFLG-CTFFIFGSLVEFAFVNTIWRRKENIELKKVNSKYIIKSTLTPRPARRQIGGSL 389
            |....: ||:. |..|:|.:|:|||.||.....:.|.||::.|                 |..:.
Zfish   298 YATAMD-WFIAVCFAFVFSALIEFAAVNYFSTLQANKELRRAN-----------------IARAA 344

  Fly   390 SNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTVHPNLPIIRTECAEADTVSICSARTNN 454
            :..:.|||               :|.|.:|             |:        |...:...|.|:
Zfish   345 AAAAAARS---------------DGEGVLN-------------PL--------DPGGVLKKRMNS 373

  Fly   455 DHIVDVDKDKKDTPPTFTTMTPQEIAM----------WIDRRSRFLFPAMFLAFNALYWTFVYV 508
              :.......:.:.|:.:....|..|:          .||:.||.|||..|.|||.:|| .||:
Zfish   374 --LSQRSATDRFSRPSQSDFHQQGSAVPANNMLIGTSIIDKYSRILFPLSFGAFNLVYW-IVYL 434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_648984.2	LIC	43..505	CDD:455710	116/482 (24%)
gabra6b	XP_002667403.3	LIC	33..433	CDD:455710	114/473 (24%)
		LGIC_ECD_GABAAR_A6	41..238	CDD:349840	45/213 (21%)
		Cys-loop	155..169	CDD:349840	5/13 (38%)