Protein Alignment SecCl and nAChRbeta2

DIOPT Version :10

• Sequence 1: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Alignment Length: 485
• Identity: 101/485 - (20%)
• Similarity: 178/485 - (36%)
• Gaps: 106/485 - (21%)

  Fly    64 FEYDSDGKRL-------------PIVVKTRIYVYFLQNLNSDLLQFKM-------HALLQLRFQD 108
            ||.:.|.|||             |:|..|.....:|....|.|::..:       :..::.|:.|
  Fly    24 FEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFD 88

  Fly   109 KRLAYKAFNRSDNILGQKHL---SERLWLPHIFFANERESSILGTDEKDVLT--SLSPEGNVIIS 168
            .:|.:.    .:...|.:.|   ||.:|:|.|...|..:    |..|..::|  :|...|.|...
  Fly    89 YKLRWD----PEEYGGVEQLYVPSEHIWVPDIVLYNNWD----GNYEVTLMTKATLKYTGEVFWE 145

  Fly   169 TRMQASLYCWMNFQKFPFDQQFCSTVLESWMYNTSDLILEWEPHTP------ISFDPEMRLTEYN 227
            ........|.||.:.||:|:|.|.....||.||.:.:.|:.....|      :..|    |||:.
  Fly   146 PPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGID----LTEFY 206

  Fly   228 MAQFWHNTTIVQSDG-----DNLRHGAFAGNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWV 287
            ::..|....:..:..     |.|.      .:|.::|.:.::|:..||.::..:|.:.:..::.:
  Fly   207 LSVEWDILEVPATKNEEYYPDTLE------PFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVL 265

  Fly   288 SFWLQADASPPRIMLGTSTMLSFITLSSSQSKNLPKVS-------------YIKVS-EVWFLGCT 338
            .|:|.:| |..::.|..|.::|........::.:|..|             .|.|| .||...|.
  Fly   266 VFYLPSD-SGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCV 329

  Fly   339 FFI---------FGSLVEFAFVN----TIWRRKENIELKKVNSKYIIKSTLTPRPARRQIGGSLS 390
            ..|         ...||...|::    .:..|:....|...:..       ||       ....:
  Fly   330 LNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYDDS-------TP-------SNGYT 380

  Fly   391 NESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTVHPNLP-IIRTECAEADTVSICSARTNN 454
            ||...|  .|:.:..|  |...:.:|..:.|..|.:.....:| .:..|..:|    :.:.|...
  Fly   381 NEIDVR--DSISDFPS--EFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQA----LRAVRFIA 437

  Fly   455 DHIVDVDKDKKDTPP-TFTTMTPQEIAMWI 483
            .||.|.|||.:.... .|.:|......:|:
  Fly   438 QHIKDADKDNEIVEDWKFVSMVLDRFFLWL 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_648984.2	LIC	43..505	CDD:455710	101/485 (21%)
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	101/485 (21%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	51/235 (22%)
		Cys-loop	154..168	CDD:349832	7/13 (54%)