Protein Alignment SecCl and nAChRalpha2

DIOPT Version :10

• Sequence 1: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Alignment Length: 430
• Identity: 93/430 - (21%)
• Similarity: 162/430 - (37%)
• Gaps: 104/430 - (24%)

  Fly    57 YDRLERPFEYDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKAFNRSDN 121
            |:||.||...::|    .::||..:.:..|.:||........:..|:..:||.:..:......
  Fly    56 YNRLIRPVSNNTD----TVLVKLGLRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYG-- 114

  Fly   122 ILGQKHL---SERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLY------- 176
              |...|   ||.:|||.|...|                  :.:|..:::|..:|.|:
  Fly   115 --GVTELYVPSEHIWLPDIVLYN------------------NADGEYVVTTMTKAILHYTGKVVW 159

  Fly   177 ---------CWMNFQKFPFDQQFCSTVLESWMYNTSDLILEWEPHTPISFDPEMR------LTEY 226
                     |.::.:.||||||.|.....||.|:...:.|:   |.....|.:.:      |.||
  Fly   160 TPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLK---HISQKNDKDNKVEIGIDLREY 221

  Fly   227 NMAQFWHNTTIVQSDGDNLRHGAF----AGNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWV 287
            ..:..|....:...     ||..:    |..|..:.|.:.|:|:..||.::..:|.:.|..:|.:
  Fly   222 YPSVEWDILGVPAE-----RHEKYYPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVL 281

  Fly   288 SFWLQADASPPRIMLGTSTMLS----FITLSS---SQSKNLPKVSYIKVSEVWFLGCTFFIFGSL 345
            .|:|.|| |..:|.|..|.:||    |:.:|.   |.|..||.:....:..:..:|.:.     :
  Fly   282 VFYLPAD-SGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSV-----V 340

  Fly   346 VEFAFVNTIWRRKENIELKKVNSKYIIKS------TLTPRPARRQI----------------GGS 388
            :....:|..:|:....:::.....:.||.      ...|:...|.:                |.:
  Fly   341 ITIIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQA 405

  Fly   389 LSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTV 428
            |.:|.:..|..      ||.:|:|...|.|..|..|.:.|
  Fly   406 LMDEMQMNSGG------SSPDSLRRMQGRVGAGGCNGMHV 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_648984.2	LIC	43..505	CDD:455710	93/430 (22%)
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	52/240 (22%)
		LIC	47..544	CDD:455710	93/430 (22%)
		Cys-loop	169..183	CDD:349832	7/13 (54%)