Protein Alignment SecCl and Grd

DIOPT Version :9

• Sequence 1: NP_001261986.1
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Alignment Length: 619
• Identity: 137/619 - (22%)
• Similarity: 220/619 - (35%)
• Gaps: 196/619 - (31%)

  Fly    34 PSMADAGSLQQTQLIQRLTHVCR-YDRLERPFEYDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFK 97
            ||.....|.....:.:.|.::.| ||...||   |..|.  |..::..|.|..:..::...:.:.
  Fly    96 PSSWLTQSNNHANISELLDNLLRGYDNSIRP---DFGGP--PATIEVDIMVRSMGPISEVDMTYS 155

  Fly    98 MHALLQLRFQDKRLAYKAFNRSDNILGQKHLSERLWLPHIFFANERESSILGTDEKDVLTSLSPE 162
            |....:..:.|||||::  ...|.:.....:..|:|.|..:|.|.::|.:......:....:...
  Fly   156 MDCYFRQSWVDKRLAFE--GAQDTLALSVSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQN 218

  Fly   163 GNVIISTRMQASLYCWMNFQKFPFDQQFCSTVLESWMYNTSDLILEW-EPHTPISFDPEMRLTEY 226
            |.|:.|:|:.....|.||...||.|.|.|.....|:.|.|||:|..| :...|::...:|:|:::
  Fly   219 GRVLYSSRLTIKAGCPMNLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQF 283

  Fly   227 NMAQF---------------------WHN-----------TTI---------VQSDGDNLRHGAF 250
            ::...                     ::|           ||.         |:..|..|..|||
  Fly   284 DLVDCPAGNLTDIVYKAAAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAF 348

  Fly   251 A--------------------------GNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSF 289
            .                          ..||.|....:|:|.:|.:|:..|.|..::|.:|||||
  Fly   349 GTGRDATGGSGSTTGLSGTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSF 413

  Fly   290 WLQADASPPRIMLGTSTMLSFITLSSSQSKNLPKVSYIKVSEVWFLGCTF-FIFGSLVEFAFVNT 353
            ||..:|:..|:.||.:|:|:...|......:||||||....: :|:..:| |||.::::||.|:
  Fly   414 WLNREATADRVSLGITTVLTMTFLGLEARTDLPKVSYPTALD-FFVFLSFGFIFATILQFAVVH- 476

  Fly   354 IWRRKENIELKKVNSK--YIIKSTLTPRPARRQIGGSLSNESRARSCSSLDNIVSSTESVRNGNG 416
                    ...|..|.  |.|...|          .|.|.||.....:|  :...||||
  Fly   477 --------YYTKYGSGECYFIIEEL----------DSESGESETEPLTS--DFRGSTES------ 515

  Fly   417 TVNQGFNNYLTVHPNLPIIRTECA-----EADTVSICSART----NNDH---------------- 456
                      .::..:|:  :.||     ....:.:.::|.    |..|
  Fly   516 ----------KIYEVIPL--SMCAISMPPPPTRLGMLTSRNRRPRNRRHGLWSMKLLGLFDWRRR 568

  Fly   457 ----IVDVDKDKKD-----------------------------TPPT------------------ 470
                ..|.|:|:.|                             :|||
  Fly   569 RKPPRADSDEDEDDEQTQLRANEAPTTSAAAAAAQAAAQAARISPPTGGRRRMSYYRREEMEARR 633

  Fly   471 FTTMTPQ-EIAMWIDRRSRFLFPAMFLAFNALYW 503
            ....||| .....|||.||.:||.:|:..|..||
  Fly   634 KGKRTPQYNSVSKIDRASRIVFPLLFILINVFYW 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	134/610 (22%)
		Neur_chan_LBD	44..267	CDD:280998	60/291 (21%)
		Neur_chan_memb	275..503	CDD:280999	70/307 (23%)
Grd	NP_524131.1	Neur_chan_LBD	110..326	CDD:280998	48/222 (22%)
		LIC	111..670	CDD:273305	134/604 (22%)
		Neur_chan_memb	398..667	CDD:280999	70/308 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447283
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840