Protein Alignment SecCl and pHCl-1

DIOPT Version :10

• Sequence 1: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_001261898.1
• Gene: pHCl-1 / 39730
• FlyBaseID: FBgn0264908
• Length: 978
• Species: Drosophila melanogaster
• Alignment Length: 596
• Identity: 128/596 - (21%)
• Similarity: 224/596 - (37%)
• Gaps: 153/596 - (25%)

  Fly    13 TLILVLSIWTSVGVKAEEEECPSMADAGSLQQ-----------------TQLIQRLTHVCRYDR- 59
            :::|:|...|:....|     .:.::.|:|.:                 .:::..|....|||:
  Fly   294 SVLLMLCYLTTASTAA-----ATQSETGALDKHPIHGIDWSKFDESSSDKEILDLLLEKKRYDKR 353

  Fly    60 -------------LERPFEYDSDGKRLP-----IVVKTRIYVYFLQNLNSDLLQFKMHALLQLRF 106
                         |:.|....:...|.|     :.|...:.:..|.:.:...|::::..||..::
  Fly   354 LLPPVNDEDFCCGLQSPDMATNQNARRPHNRGTLTVNVNVLLLSLASPDESSLKYEVEFLLNQQW 418

  Fly   107 QDKRLAYKAFNRSD-NILGQKHLSERLWLPHIFFANERESSILGTDEKDVLTSLS------PEGN 164
            .|.||.|.  |:|. :.|...|..:.:|.|..:|       |:..|.||.:..:.      ..|.
  Fly   419 NDPRLQYG--NKSHYDFLNALHHHDSIWTPDTYF-------IMHGDFKDPIIPMHFALRIFRNGT 474

  Fly   165 VIISTRMQASLYCWMNFQKFPFDQQFCSTVLESWMYNTSDLILEWEPHTPISFDPEMR----LTE 225
            :..:.|....|.|..:...||||...||..:||..|..:.:...|:     :.:..:|    ||.
  Fly   475 ITYAMRRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQIKYVWK-----NDEDTLRKSPSLTT 534

  Fly   226 YNMAQFWHNTTIVQSDGDNLRHGAFAGNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFW 290
            .|.....:.||....:       ::.||||.|...:...|:..:|....::|.:::|..|:::||
  Fly   535 LNAYLIKNQTTACDQN-------SWRGNYSCLQVELTFTRDRAYYFTTVFIPGIILVTSSFITFW 592

  Fly   291 LQADASPPRIMLGTSTMLSFITLSSSQSKNLPKVSYIKVSEVWFLGCTFFIFGSLVEFAFVNTIW 355
            |:.:|.|.|:|:|.:|||:|.|.|:.....||.||.:....||...|..||:.||:||..||.:.
  Fly   593 LEWNAVPARVMIGVTTMLNFFTTSNGFRSTLPVVSNLTAMNVWDGVCMCFIYASLLEFVCVNYVG 657

  Fly   356 RRK--ENI-----------ELKKVNSK--YIIKSTL---TPRPARRQIGGSLSNESRARSCSS-- 400
            |::  .|:           .|..|.|:  .|:.|.|   ...||...:||:....|...:.||
  Fly   658 RKRPLHNVVYRPGENPVTQRLPAVLSRIGVILASPLASAAATPAMSMMGGATPMSSGTPAASSSV 722

  Fly   401 ----LDNIVSSTESVRNG-------NGTVNQGFNNY----------------LTVHPN------- 431
                ...|....|....|       .|.:.....|.                ::.||:
  Fly   723 ATPGTPRITDPEEFFGGGMRWQEAHGGIIGAAVQNLRARSIKRKAARSPSTSISPHPSGRPTEHI 787

  Fly   432 ---------------------LPIIRTECAEADTVSICSARTNNDHIV-----DVDKDKKDTPPT 470
                                 |...:.|.||:.|....|..|:...:|     ::|.:.:|.|..
  Fly   788 YEEPGGSTSGVTSTKVKFKDELKEEQPEEAESSTKLRRSVATSTPALVVRIEAEIDPEAEDKPIQ 852

  Fly   471 FTTMTPQEIAM 481
            ...||.:::::
  Fly   853 DMEMTERQLSL 863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_648984.2	LIC	43..505	CDD:455710	122/566 (22%)
pHCl-1	NP_001261898.1	LIC	339..>662	CDD:455710	88/343 (26%)
		LGIC_TM	<948..975	CDD:476813
		TM4 helix	950..971	CDD:349850