DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SecCl and Rdl

DIOPT Version :9

Sequence 1:	NP_001261986.1	Gene:	SecCl / 39949	FlyBaseID:	FBgn0036727	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001261617.1	Gene:	Rdl / 39054	FlyBaseID:	FBgn0004244	Length:	608	Species:	Drosophila melanogaster

Alignment Length:	610	Identity:	143/610 - (23%)
Similarity:	236/610 - (38%)	Gaps:	155/610 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VLSIWTSVGVKAEEEE--------CPSMADAGSLQQTQLIQRL--THVCRYDRLERPFEYDSDGK 71
            :|:||.::.:....:|        ..:....||:.....|..:  :....||:..|| .|...
  Fly    20 LLTIWLAINMALIAQETGHKRIHTVQAATGGGSMLGDVNISAILDSFSVSYDKRVRP-NYGGP-- 81

  Fly    72 RLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKAFNRSDNILGQKHLSERLWLPH 136
              |:.|...:||..:.:|:...:.|.:....:..:.|.||||:.....:.:.......:.:|:|.
  Fly    82 --PVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPGVETLSVGSEFIKNIWVPD 144

  Fly   137 IFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQFCSTVLESWMYN 201
            .||.||::|........:....:...|::..|.|:..:..|.||.|.||.|:|.|...:||:.|.
  Fly   145 TFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFPMDRQLCHIEIESFGYT 209

  Fly   202 TSDLILEW-EPHTPISFDPEMRLTEYNMAQFWHNTTIVQSDGDNLRHGAFAGNYSSLSFTVNLKR 265
            ..|:...| :..:.:....|:.|.::.:.......|.:     ||.    .||||.|:..:...|
  Fly   210 MRDIRYFWRDGLSSVGMSSEVELPQFRVLGHRQRATEI-----NLT----TGNYSRLACEIQFVR 265

  Fly   266 EIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSKNLPKVSYIKVS 330
            .:|:||:..|:||.:||.||||||||..:|:|.|:.||.:|:|:..||.||.:..|||:||:|..
  Fly   266 SMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPKISYVKSI 330

  Fly   331 EVWFLGCTFFIFGSLVEFAFVNTIWRRKENIELKKVNSKYIIKSTLTPRPARRQIGGSLSNESRA 395
            :|:...|...:|.||:|:|.|..:.:|   |:::|.....|.|   .....::|:.|  :|:.:|
  Fly   331 DVYLGTCFVMVFASLLEYATVGYMAKR---IQMRKQRFMAIQK---IAEQKKQQLDG--ANQQQA 387

  Fly   396 RSCSSLDNIVSSTESVRNG-------NGTVN--------------QGFNNYLTVHPNLPIIRTEC 439
            ....:.:  |.....|..|       .|.||              .|.:.:...||:.|
  Fly   388 NPNPNAN--VGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAP------ 444

  Fly   440 AEADTVSI----------------CS-------------------------ARTNND-------- 455
              ..|||.                ||                         ..|.|.
  Fly   445 --KQTVSNRPIGFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQSH 507

  Fly   456 ------------------------------------HIVDVDKDKK-DTPPTFTTMTPQEIAMWI 483
                                                |::...|.|| ........:||.:    |
  Fly   508 GPGPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLLGITPSD----I 568

  Fly   484 DRRSRFLFPAMFLAFNALYWTFVYV 508
            |:.||.:||..|:.||.:|| .:|:
  Fly   569 DKYSRIVFPVCFVCFNLMYW-IIYL 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	136/571 (24%)
		Neur_chan_LBD	44..267	CDD:280998	52/225 (23%)
		Neur_chan_memb	275..503	CDD:280999	79/334 (24%)
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	44/191 (23%)
Rdl	NP_001261617.1	Neur_chan_memb	274..588	CDD:397193	79/335 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447292
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840