Protein Alignment SecCl and nAChRbeta1

DIOPT Version :10

• Sequence 1: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Alignment Length: 548
• Identity: 111/548 - (20%)
• Similarity: 209/548 - (38%)
• Gaps: 135/548 - (24%)

  Fly    11 WITL-ILVLSIWTSVGVKAEEEECPSMADAGSLQQTQLIQRLTHVCRYDRLERPFEYDSDGKRLP 74
            |:.. ||||..::.|....:||              :|::.|..  .|::|.||.:      .:.
  Fly     8 WLLCSILVLVAFSLVSASEDEE--------------RLVRDLFR--GYNKLIRPVQ------NMT 50

  Fly    75 IVVKTRIYVYFLQ--NLNSDLLQFKMHALLQLRFQDKRLAYKAFNRSDNILGQKHL-SERLWLPH 136
            ..|..|..:.|:|  |:|......|.:..|:|.:.|.:|.:...:...  :|...| .:::|.|.
  Fly    51 QKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQWDEADYGG--IGVLRLPPDKVWKPD 113

  Fly   137 IFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLY---CWMNFQKFPFDQQFCSTVLESW 198
            |...|..:.:.....:.:||  :.|.|.|:   .:..::|   |.::...||||||.|.....||
  Fly   114 IVLFNNADGNYEVRYKSNVL--IYPTGEVL---WVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSW 173

  Fly   199 MYNTSDLILEWEPHTPISFDPEMRLTEYN------MAQFWHNTT--IVQ-------SDGDNLRHG 248
            .:|                ..::.|..||      ::.:|.:.|  |::       .:||:
  Fly   174 TFN----------------GDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLNVYEGDS---- 218

  Fly   249 AFAGNY---SSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSF 310
                |:   :.::|.:.::|:..||.::..||:::|..:..:.|:|.|:|. .::.||.|.:||.
  Fly   219 ----NHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAG-EKVTLGISILLSL 278

  Fly   311 ITLSSSQSKNLPKVSYIKVSEVWFLGCTFFI--FGSLVEFAFVNTIWR----RKENIELKKVNSK 369
            :......||.||..|.:......:|..||.:  ...||....:|..:|    .:..:.::.:...
  Fly   279 VVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIFLH 343

  Fly   370 YIIKSTLTPRPARRQIGGSLSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTV------ 428
            |:.......||.:.::...:.....:.......:..|..|..::.:..  .|..:.:.|
  Fly   344 YLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAI--GGKQSKMEVMELSDL 406

  Fly   429 -HPNLPI---------------IRTECAEADTVSI---CSART-----------NNDHIVDVDKD 463
             |||..|               .|.|...:|::.:   .|..|           |.|..:...:|
  Fly   407 HHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLRNEDLYIQTRED 471

  Fly   464 KKDTPPTFTTMTPQEIAMWIDRRSRFLF 491
            .|            .:||.|||...::|
  Fly   472 WK------------YVAMVIDRLQLYIF 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_648984.2	LIC	43..505	CDD:455710	103/515 (20%)
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	111/548 (20%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	53/261 (20%)
		Cys-loop	152..166	CDD:349833	7/13 (54%)