Protein Alignment SecCl and lgc-38

DIOPT Version :9

• Sequence 1: NP_001261986.1
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_001355511.1
• Gene: lgc-38 / 3565717
• WormBaseID: WBGene00017389
• Length: 479
• Species: Caenorhabditis elegans
• Alignment Length: 482
• Identity: 136/482 - (28%)
• Similarity: 221/482 - (45%)
• Gaps: 80/482 - (16%)

  Fly    45 TQLIQRLTHVCRYDRLERPFEYDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDK 109
            |:|:.:|  :..:||..|| .|...    ||.|....:|..:..::...:.:.:...|:..::|.
 Worm    53 TRLLDKL--IASHDRRIRP-NYGGP----PIEVNITAHVTTISAVSEVSMDYTLDLYLRQIWKDP 110

  Fly   110 RLAYKAFNRSDNILGQKHLSERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQAS 174
            |||::: :..|::.....:.:.:|.|..||.||::|........:....:...|||:.|.|:..:
 Worm   111 RLAWES-DVEDSLTIGIDMVKTIWTPDTFFPNEKKSFFHEATSHNSFLRIDNHGNVLRSIRLTVT 174

  Fly   175 LYCWMNFQKFPFDQQFCSTVLESWMYNTSDLILEWEPHTPISFDPEMRLTEYNMAQFWH-NTTIV 238
            ..|.|:...||.|:|.|:..:||:.|:|.|:|..|.....::.|..:.|..:.:.:..| ..||.
 Worm   175 ANCPMSLHTFPLDRQECALEVESYGYSTKDIIYHWHGTNAVTIDENVHLAHFTIGEHKHIERTIS 239

  Fly   239 QSDGDNLRHGAFAGNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLG 303
            .|          .||||.|:.....||.|||||:..|.||.:||.||||||||..:|...|:.:|
 Worm   240 LS----------TGNYSRLTAYFLFKRNIGFYLIQIYFPSSLIVVISWVSFWLNREAVQARVAIG 294

  Fly   304 TSTMLSFITLSSSQSKNLPKVSYIKVSEVWFLG-CTFFIFGSLVEFAFVNTIWRRKENI----EL 363
            .:|:|:..||.:|.:.:||||||:|..:| ||| |.|.:|.||:|:|.:..:.:|..::    .:
 Worm   295 VTTVLTMTTLMTSTNASLPKVSYVKSLDV-FLGVCFFIVFASLLEYAAIGYLMKRNRSVPAASPV 358

  Fly   364 KKVNSKYIIKSTLTPRPARRQIG---GSLSNE-----SRARSCSSLDNIVSSTESVRNGNGTVNQ 420
            :...::...:....|:..|..|.   |.|..|     ||.|..||:.|..::....|..:|.|:|
 Worm   359 QYYETEEFFEIQCHPKFVRGAINYCDGVLKREASRKKSRNRRDSSMKNYQNNNIHHRPSDGHVDQ 423

  Fly   421 GFNNYLTVHPNLPIIRTECAEADTVSICSARTNNDHIVDVDKDKKDTPPTFTTMTPQEIAMW--- 482
                      .:|::                           .....||  ....||..| |
 Worm   424 ----------RIPLL---------------------------SMVPMPP--IPFKPQNGA-WGKV 448

  Fly   483 ----IDRRSRFLFPAMFLAFNALYWTF 505
                :|..|||.||..|:.|:.:|||:
 Worm   449 RPAQVDLFSRFAFPIFFVIFHIVYWTY 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	135/480 (28%)
		Neur_chan_LBD	44..267	CDD:280998	57/222 (26%)
		Neur_chan_memb	275..503	CDD:280999	71/247 (29%)
lgc-38	NP_001355511.1	LIC	42..476	CDD:273305	136/482 (28%)
		LGIC_ECD_GABAR_RDL-like	76..257	CDD:349809	47/191 (25%)
		Cys-loop	177..191	CDD:349809	6/13 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810