DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SecCl and srsx-31

DIOPT Version :9

Sequence 1:	NP_001261986.1	Gene:	SecCl / 39949	FlyBaseID:	FBgn0036727	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001023767.1	Gene:	srsx-31 / 3565162	WormBaseID:	WBGene00008552	Length:	308	Species:	Caenorhabditis elegans

Alignment Length:	182	Identity:	33/182 - (18%)
Similarity:	67/182 - (36%)	Gaps:	45/182 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 PISFDPEMRLTEYNMAQFWHNTTIVQSDGDNLRHGAFAGNYSSLSFTVNLKREIGFYLLDYYL-- 276
            ||:|...:.:..|....:  ||.|:......|...|| |.::..|..:|:|..| .|...|::
Worm   132 PITFTSALMIYGYQFIDY--NTQIICMAPLALPRQAF-GYFTYSSNIINVKIVI-VYAYTYFVLR 192

  Fly   277 ------------------PSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSKNLPK 323
                              .::::|.|.|.                |.|:.:.|.|...:.::..:
Worm   193 GYKERDANRMRYVFKSIALTVIVVLIGWT----------------TVTIGNTIALGVIEDRHTSE 241

  Fly   324 VSYIKVSEVWFLGCTFFIFGSLVEFAFVNTIWRRK-ENIELKKVNSKYIIKS 374
            :..|.......:.|:.    :::.|..:|:.:|.. ..:...|::|..:.||
Worm   242 IISIHAGFGVNISCSI----NVIVFYAINSEYRSAIRRLFGMKIHSSDVSKS 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	33/182 (18%)
		Neur_chan_LBD	44..267	CDD:280998	14/52 (27%)
		Neur_chan_memb	275..503	CDD:280999	16/121 (13%)
srsx-31	NP_001023767.1	TM helix 1	11..36	CDD:341315
		7TM_GPCR_Srsx	19..277	CDD:255903	29/168 (17%)
		TM helix 2	43..67	CDD:341315
		TM helix 3	79..109	CDD:341315
		TM helix 4	122..140	CDD:341315	3/7 (43%)
		TM helix 5	165..190	CDD:341315	9/26 (35%)
		TM helix 6	201..230	CDD:341315	5/44 (11%)
		TM helix 7	241..266	CDD:341315	3/28 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900