Protein Alignment SecCl and nAChRalpha6

DIOPT Version :10

• Sequence 1: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Alignment Length: 494
• Identity: 110/494 - (22%)
• Similarity: 189/494 - (38%)
• Gaps: 108/494 - (21%)

  Fly    15 ILVLSIWTSVGVKAEEEECPSMADAGSLQQTQLIQRLTHVCRYDRLERPFEYDSDGKRLPIVVKT 79
            :.||.|:.:: :|   |.|...      .:.:|:..|  :..|:.||||...:|:    |:.||.
  Fly    11 LFVLLIFLAI-IK---ESCQGP------HEKRLLNHL--LSTYNTLERPVANESE----PLEVKF 59

  Fly    80 RIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKAFNRSDNILGQKHL---SERLWLPHIFFAN 141
            .:.:..:.:::........:|.|.|.:.|..|.:......    |.|.|   ..:||.|.:...|
  Fly    60 GLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYG----GVKDLRITPNKLWKPDVLMYN 120

  Fly   142 ERESSILGTDEKDVLTSLS------PEGNVIISTRMQASLYCWMNFQKFPFDQQFCSTVLESWMY 200
            ..:....||...:::...:      |.| :..||       |.::...||||.|.|.....||.|
  Fly   121 SADEGFDGTYHTNIVVKHNGSCLYVPPG-IFKST-------CKIDITWFPFDDQHCEMKFGSWTY 177

  Fly   201 --NTSDLILEWEPHTPISFDPEMRLTEYNMAQFWHNTTIVQSDGDNLRHGAFAGNYSSLSFTVNL 263
              |..||:|..|....:| |.......|.:|......|||        :......|..::||:.:
  Fly   178 DGNQLDLVLNSEDGGDLS-DFITNGEWYLLAMPGKKNTIV--------YACCPEPYVDITFTIQI 233

  Fly   264 KREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLS---FITLSSSQ-------- 317
            :|...:|..:..:|.::|.:::.:.|.|..| |..::.||.:.:||   |:.|.:..
  Fly   234 RRRTLYYFFNLIVPCVLISSMALLGFTLPPD-SGEKLTLGVTILLSLTVFLNLVAESMPTTSDAV 297

  Fly   318 ------------------SKNLPKVS-YIKVSEVWFLGCTFFIFGSLVEFAFVNTIWRRKENIE- 362
                              ::.||:|| .|.:...:|....|.:..|:|....|.....|..:|.
  Fly   298 PLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHE 362

  Fly   363 ----LKKVNSKYIIKSTLTPRPARRQIGGS--LSN-----ESRARSCSS-LDNIVSSTESVR--- 412
                :|.|..:::.......||.|:....:  |||     |.:.||..| |.|::...:..|
  Fly   363 MPPWIKSVFLQWLPWILRMGRPGRKITRKTILLSNRMKELELKERSSKSLLANVLDIDDDFRHTI 427

  Fly   413 NGNGTV---NQGFNNYLTV----------HPNLPIIRTE 438
            :|:.|.   :..|....||          |.:|.:|..|
  Fly   428 SGSQTAIGSSASFGRPTTVEEHHTAIGCNHKDLHLILKE 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_648984.2	LIC	43..505	CDD:455710	104/466 (22%)
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	110/494 (22%)
		LGIC_ECD_nAChR	55..236	CDD:349798	45/201 (22%)
		Cys-loop	154..168	CDD:349798	6/13 (46%)