Protein Alignment SecCl and nAChRalpha7

DIOPT Version :9

• Sequence 1: NP_001261986.1
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 397
• Identity: 80/397 - (20%)
• Similarity: 145/397 - (36%)
• Gaps: 97/397 - (24%)

  Fly    49 QRLTHVC--RYDRLERPFEYDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRL 111
            :||.|..  .|:.||||...:||..:|...: |.:.:..:...|..|:   .:..|:|.:.|..|
  Fly    62 KRLLHALLDNYNSLERPVVNESDPLQLSFGL-TLMQIIDVDEKNQLLI---TNIWLKLEWNDMNL 122

  Fly   112 AYKAFNRSDNILGQKHL---SERLWLPHIFFANERESSILGTDEKDVLTSLS------PEGNVII 167
            .:    .|....|.:.|   ..|||.|.:...|..:....||...:|:...:      |.| :..
  Fly   123 RW----NSSEFGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYATNVVVRNNGSCLYVPPG-IFK 182

  Fly   168 STRMQASLYCWMNFQKFPFDQQFCSTVLESWMYNTSDLILEWEPHTPISFDPEMRLTEYNMAQFW 232
            ||       |.::...||||.|.|.....||.|:...|.|:.:..........:...|:::..
  Fly   183 ST-------CKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGGDISSFITNGEWDLLG-- 238

  Fly   233 HNTTIVQSDGDNLRHGAFAGNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASP 297
                 |....:.:.:......|..::|.:.::|:..:|..:..:|.::|.:::.:.|.|..| |.
  Fly   239 -----VPGKRNEIYYNCCPEPYIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPD-SG 297

  Fly   298 PRIMLGTSTMLSFITLSSSQSKNLPKVSYIKVSEVWFLGCTFFIFGSLVEFAFVNTI-------- 354
            .::.||.:.:||.....:..::.:|..|    ..|..||..|.....:|..:.|:||
  Fly   298 EKLSLGVTILLSLTVFLNMVAETMPATS----DAVPLLGTYFNCIMFMVASSVVSTILILNYHHR 358

  Fly   355 ---------WRRK-----------------------------------------ENIELKKVNSK 369
                     |.|.                                         :|:|||:.:||
  Fly   359 NPDTHEMSEWIRVIFLYWLPCILRMQRPGQVGYECPPPPSSSSSSASGEKKQQIQNVELKERSSK 423

  Fly   370 YIIKSTL 376
            .::.:.|
  Fly   424 SLLANVL 430

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	80/397 (20%)
		Neur_chan_LBD	44..267	CDD:280998	50/228 (22%)
		Neur_chan_memb	275..503	CDD:280999	29/160 (18%)
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	80/397 (20%)
		Neur_chan_LBD	61..268	CDD:280998	50/228 (22%)
		Neur_chan_memb	275..552	CDD:280999	29/161 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447258
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030