DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SecCl and Lcch3

DIOPT Version :9

Sequence 1:	NP_001261986.1	Gene:	SecCl / 39949	FlyBaseID:	FBgn0036727	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	141/509 - (27%)
Similarity:	237/509 - (46%)	Gaps:	85/509 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 AGSLQQ-TQLIQRLTHVCRYDRLERPFEYDSDGKRLPIVVKTRIYVY-FLQNLNSDLLQFKMHAL 101
            ||.|:. ||.|..:..  .||...||   :..|:.|.:.:...|..: .:..:|.|   :.:...
  Fly    34 AGRLENVTQTISNILQ--GYDIRLRP---NFGGEPLHVGMDLTIASFDAISEVNMD---YTITMY 90

  Fly   102 LQLRFQDKRLAYKAFNR----------SDNILGQKHLSERLWLPHIFFANERESSILGTDEKDVL 156
            |...::|:|||:..|.:          ||.:......:|::|:|..||||::.|.:....|::.|
  Fly    91 LNQYWRDERLAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKL 155

  Fly   157 TSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQFCSTVLESWMYNTSDLILEWEPHTPISFDPEM 221
            ..|..:|.|....|...:|.|.|:...:|.|.|.|:..:||:.|..||:::.|:| ||:....:.
  Fly   156 VRLGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKP-TPVRGVEDA 219

  Fly   222 RLTEYNMAQFWHNTTIVQSDGDNLRHGAFAGNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISW 286
            .|.::         ||:..:.::.:.....|.|..||.:..|:|.||:::...||||::||.:||
  Fly   220 ELPQF---------TIIGYETNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSW 275

  Fly   287 VSFWLQADASPPRIMLGTSTMLSFITLSSSQSKNLPKVSYIKVSEVWFLGCTFFIFGSLVEFAFV 351
            ||||:..:|:..|:.||.:|:|:..|:|:....:||::||:|..:::.:.|..|:|.:|:|:|.|
  Fly   276 VSFWINHEATSARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAV 340

  Fly   352 N-TIWRRKENIELKKVNSKYIIKSTLTPRPARRQIGGSLSNESRARSCSSLDNIV-------SST 408
            | |.|.::...::|||               :....|.:....|:.:||:.::|:       |..
  Fly   341 NYTYWGKRAKKKIKKV---------------KECCPGKIGKSERSETCSTTEDIIELQDVRMSPI 390

  Fly   409 ESVRN----------GNGTVNQG--------FNNYLTVHPNLPIIRTECAEADTVSICSARTNND 455
            .|:|.          |..|:|.|        ..||.|.|..|   |......     .|.|....
  Fly   391 PSLRRGTYNATLDSIGTETMNLGKFPPSFRITRNYGTGHSQL---RRRAQRG-----ISTRPRML 447

  Fly   456 HIVDVDKDKKDTPPTFTTMTPQEIAMWIDRRSRFLFPAMFLAFNALYWTFVYVL 509
            |.:     |:.......|:...:....||:.||.:||..|||||..||.| |:|
  Fly   448 HAL-----KRGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWLF-YIL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	135/499 (27%)
		Neur_chan_LBD	44..267	CDD:280998	59/234 (25%)
		Neur_chan_memb	275..503	CDD:280999	72/253 (28%)
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	139/505 (28%)
		Neur_chan_LBD	47..256	CDD:280998	56/226 (25%)
		Neur_chan_memb	263..490	CDD:280999	72/254 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447277
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840