DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SecCl and CG8916

DIOPT Version :9

Sequence 1:	NP_001261986.1	Gene:	SecCl / 39949	FlyBaseID:	FBgn0036727	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_573090.3	Gene:	CG8916 / 32553	FlyBaseID:	FBgn0030707	Length:	612	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	132/521 - (25%)
Similarity:	233/521 - (44%)	Gaps:	80/521 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 ADAGSLQQTQLIQRLTHVCRYDRLERPFEYDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHAL 101
            ||..|...:.:::.|  :.||::.:.|    :.|:.:|.||:|.|.:..:..::...:.:.|...
  Fly   101 ADMLSRNISMILENL--LKRYEQSQLP----THGQGVPTVVQTNILIRSMGPVSELDMDYSMDCY 159

  Fly   102 LQLRFQDKRLAYKAFNRSDNILGQKHLSERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVI 166
            .:..::||||::|...:|.: |..|.| :::|.|..:|.|.:.|.|......:.|..|...|.::
  Fly   160 FRQYWRDKRLSFKGPIKSLS-LSIKML-DKIWRPDTYFYNGKHSQIHMITVPNKLLRLDQNGGIL 222

  Fly   167 ISTRMQASLYCWMNFQKFPFDQQFCSTVLESWMYNTSDLILEWE-PHTPISFDPEMRLTEYNMAQ 230
            .|.|:.....|.|..|.||.|:|.|..|:.|:.|....||.||: ....:||.|.|.|.::::..
  Fly   223 YSMRLTIKATCPMELQNFPMDRQSCPLVIGSYGYINQQLIYEWKNQDDAVSFVPGMTLNQFDLIS 287

  Fly   231 FWH-NTTIVQSDGDNLRHGAFAGNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQAD 294
            ..| |.|.|:.:||          :|.|....||||..|::|:..|:|.::||.:||||||:..:
  Fly   288 MMHRNFTTVRREGD----------FSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFWIHRE 342

  Fly   295 ASPPRIMLGTSTMLSFITLSSSQSKNLPKVSYIKVSEVWFLGCTF-FIFGSLVEFAFVN--TIWR 356
            |:..|:.|..:::|:..|:|.....:||||.|....: |||..:| :...:|:|||.|:  |...
  Fly   343 ATSDRVSLCVTSVLTLSTISLDSRTDLPKVKYATALD-WFLLMSFLYCIATLLEFAGVHYFTKLG 406

  Fly   357 RKENIELKKVNSKYIIKSTLTPRPARRQIGGS-------LSNESRARSCSSLDNIVSSTESVRNG 414
            ..|:.:|:.......|.::|:....  ::.|.       .::|..:....:.||...::|||.:.
  Fly   407 SGESPQLEDQWEDICIANSLSDHAG--EVDGDGEADADPFADEDSSNGSENDDNEAGASESVESK 469

  Fly   415 NGTVNQGFNNYLTVHPNLPIIRTECAEADTVS----ICSARTNNDHIV--DVDKDKKDTPPTFTT 473
            :|......|:.|.:...:. ::...|.|..:.    .|....:..:|:  .:::..:..||..:.
  Fly   470 SGVCVCNKNDALGLEYEVS-LQNSLAGAGFLKRNAIFCPTYNDPSYILPNTMERTTQTEPPAVSR 533

  Fly   474 MTPQEIAMW------------------------------------IDRRSRFLFPAMFLAFNALY 502
            :.    .||                                    |||.:|..||..|...|.||
  Fly   534 LH----QMWMCLKSDNSFRKQRERNAAAQKSEQGGANCYVNSVSLIDRVARIAFPMSFAFLNLLY 594

  Fly   503 W 503
            |
  Fly   595 W 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	129/515 (25%)
		Neur_chan_LBD	44..267	CDD:280998	63/224 (28%)
		Neur_chan_memb	275..503	CDD:280999	62/279 (22%)
CG8916	NP_573090.3	LIC	92..598	CDD:273305	132/521 (25%)
		Neur_chan_LBD	111..315	CDD:280998	63/221 (29%)
		Neur_chan_memb	322..>403	CDD:280999	30/81 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910