Protein Alignment SecCl and Gabra1

DIOPT Version :10

• Sequence 1: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_899155.1
• Gene: Gabra1 / 29705
• RGDID: 61855
• Length: 455
• Species: Rattus norvegicus
• Alignment Length: 516
• Identity: 137/516 - (26%)
• Similarity: 225/516 - (43%)
• Gaps: 102/516 - (19%)

  Fly     6 LSEIFWI-TLILVLSIWTSVGVKAEEEECPSMADAGSLQQTQLIQRLTHVCRYDRLERPFEYDSD 69
            ||:..|. ||||......|.|..:::|    :.| .:...|:::.||  :..||...||    ..
  Rat     7 LSDYLWAWTLILSTLSGRSYGQPSQDE----LKD-NTTVFTRILDRL--LDGYDNRLRP----GL 60

  Fly    70 GKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYK---AFNRSDNILGQKHLSER 131
            |:|: ..|||.|:|.....::...:::.:....:..::|:||.:|   ...|.:|::..|
  Rat    61 GERV-TEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASK----- 119

  Fly   132 LWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQFCSTVLE 196
            :|.|..||.|.::|........:.|..::.:|.::.:.|:.....|.|:.:.||.|...|.....
  Rat   120 IWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFG 184

  Fly   197 SWMYNTSDLILEW--EP-HTPISFDPEMRLTEYNMAQFWHNTTIVQSDGDNLRHGAFAGNYSSLS 258
            |:.|..::::.||  || .:.:..:...||.:|::.....::.||||.         .|.|..::
  Rat   185 SYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSS---------TGEYVVMT 240

  Fly   259 FTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSKNLPK 323
            ...:|||:||::::..|||.:|.|.:|.|||||..::.|.|.:.|.:|:|:..|||.|...:|||
  Rat   241 THFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPK 305

  Fly   324 VSYIKVSEVWFLG-CTFFIFGSLVEFAFVNTI------WRRKENI--ELKKVNSKYIIKSTLTPR 379
            |:|....: ||:. |..|:|.:|:|||.||..      |..|..:  :.|||... :||...|..
  Rat   306 VAYATAMD-WFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDP-LIKKNNTYA 368

  Fly   380 PARRQIGGSLSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTVHPNLPIIRTECAEADT 444
            |.......:|     ||....|..|..|.                  |:.|.
  Rat   369 PTATSYTPNL-----ARGDPGLATIAKSA------------------TIEPK------------- 397

  Fly   445 VSICSARTNNDHIVDVDKDKKDTPP--TFTTMTPQEIAMWIDRRSRFLFPAMFLAFNALYW 503
                          :|..:.|...|  ||.:::.      |||.||..||.:|..||.:||
  Rat   398 --------------EVKPETKPPEPKKTFNSVSK------IDRLSRIAFPLLFGIFNLVYW 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_648984.2	LIC	43..505	CDD:455710	126/478 (26%)
Gabra1	NP_899155.1	LIC	7..441	CDD:455710	137/516 (27%)
		LGIC_ECD_GABAAR_A1	55..248	CDD:349835	48/211 (23%)
		Cys-loop	165..179	CDD:349835	5/13 (38%)